The activity of the β-secretase involved in the cleavage of amyloid-β (Aβ) is increased in sporadic late-onset Alzheimer's disease (AD). Whether the corresponding γ-secretase activity is altered is still uncertain. We evaluated mRNA expression and protein levels of presenilin 1 (PS1) and γ-secretase activity in the frontal cortex of 32 cases with late-onset sporadic AD and those of 29 control subjects. We found a significant increase in PS1 mRNA, protein levels and γ-secretase activity in AD cases. These findings suggest that upregulation of PS1 leads to Aβ overproduction and accumulation in sporadic AD.

Upregulation of presenilin 1 in brains of sporadic, late-onset Alzheimer's disease.

GUGLIELMOTTO, Michela;TAMAGNO, Elena;
2010-01-01

Abstract

The activity of the β-secretase involved in the cleavage of amyloid-β (Aβ) is increased in sporadic late-onset Alzheimer's disease (AD). Whether the corresponding γ-secretase activity is altered is still uncertain. We evaluated mRNA expression and protein levels of presenilin 1 (PS1) and γ-secretase activity in the frontal cortex of 32 cases with late-onset sporadic AD and those of 29 control subjects. We found a significant increase in PS1 mRNA, protein levels and γ-secretase activity in AD cases. These findings suggest that upregulation of PS1 leads to Aβ overproduction and accumulation in sporadic AD.
2010
22
771
775
Borghi R; Piccini A; Barini E; Cirmena G; Guglielmotto M; Tamagno E; Fornaro M; Perry G; Smith MA; Garuti A; Tabaton M.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/80099
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