Recent findings suggest the involvement of the MET oncogene, encoding the tyrosine kinase receptor for hepatocyte growth factor, in the onset and progression of basal-like breast carcinoma. The expression profiles of basal-like tumors - but not those of other breast cancer subtypes - are enriched for gene sets that are coordinately over-represented in transcriptional signatures regulated by Met. Consistently, tissue microarray analyses have revealed that Met immunoreactivity is much higher in basal-like cases of human breast cancer than in other tumor types. Finally, mouse models expressing mutationally activated forms of Met develop a high incidence of mammary tumors, some of which exhibit basal characteristics. The present review summarizes current knowledge on the role and activity of Met in basal-like breast cancer, with a special emphasis on the correlation between this tumor subtype and the cellular hierarchy of the normal mammary gland.

The Met oncogene and basal-like breast cancer: another culprit to watch out for?

GASTALDI, Stefania;COMOGLIO, Paolo;TRUSOLINO, Livio
2010-01-01

Abstract

Recent findings suggest the involvement of the MET oncogene, encoding the tyrosine kinase receptor for hepatocyte growth factor, in the onset and progression of basal-like breast carcinoma. The expression profiles of basal-like tumors - but not those of other breast cancer subtypes - are enriched for gene sets that are coordinately over-represented in transcriptional signatures regulated by Met. Consistently, tissue microarray analyses have revealed that Met immunoreactivity is much higher in basal-like cases of human breast cancer than in other tumor types. Finally, mouse models expressing mutationally activated forms of Met develop a high incidence of mammary tumors, some of which exhibit basal characteristics. The present review summarizes current knowledge on the role and activity of Met in basal-like breast cancer, with a special emphasis on the correlation between this tumor subtype and the cellular hierarchy of the normal mammary gland.
2010
12
4(208)
1
10
http://dx.doi.org/10.1186/bcr2617
HEPATOCYTE GROWTH-FACTOR; FUNCTIONAL MAMMARY-GLAND; C-MET; TYROSINE KINASE; FACTOR RECEPTOR; SCATTER FACTOR; SIGNALING PATHWAY; ESTROGEN-RECEPTOR; MET/HGF RECEPTOR; LUNG-CANCER
S. Gastaldi;P. M. Comoglio;L. Trusolino
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/80860
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