Insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding proteins (IGFBPs) might play a pathogenic role in heart failure. We showed significantly increased myocardial IGFBP-3 expression (investigated by real-time polymerase chain reaction) and apoptosis (detected by flow cytometry) in 23 failing hearts from patients undergoing cardiac transplantation for end-stage dilated or ischemic cardiomyopathy, when compared with 10 controls. Higher IGF-1 mRNA levels were shown only in end-stage dilated cardiomyopathy.

Myocardial Insulin-like Growth Factor-1 and Insulin-like Growth Factor Binding Protein-3 Gene Expression in Failing Hearts Harvested From Patients Undergoing Cardiac Transplantation

ZANINI, CRISTINA;GRANATA, Riccarda;BROGLIO, Fabio;BERGAMASCO, Laura Maria;RINALDI, Mauro;GHIGO, Ezio
2009-01-01

Abstract

Insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding proteins (IGFBPs) might play a pathogenic role in heart failure. We showed significantly increased myocardial IGFBP-3 expression (investigated by real-time polymerase chain reaction) and apoptosis (detected by flow cytometry) in 23 failing hearts from patients undergoing cardiac transplantation for end-stage dilated or ischemic cardiomyopathy, when compared with 10 controls. Higher IGF-1 mRNA levels were shown only in end-stage dilated cardiomyopathy.
2009
28
4
402
405
IGF/IGFBP system; Cardiomyopathy
A. Pucci; C. Zanini; R. Granata; R. Ghignone; A. Iavarone; F. Broglio; P. Sorrentino; L. Bergamasco; M. Rinaldi; E. Ghigo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/82303
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