A prospective study was performed in 21 renal cell carcinomas (RCC) to clarify the prognostic role of AgNOR counting. Sections were stained in 1990 with the method of Ploton: the mean AgNOR count for the whole series was 6.13, the median 5.94 amd the SD 1.78. Patients were then followed up for at least 6 years or to death. At the time of analysis (1996), 13 patients were alive, without evidence of recurrence or metastasis, 6 had died of the disease and 2 of myocardial infarction. All the patients with 5.94 AgNOR per cell or fewer were alive, while only 60% of patient with more than 5.94 AgNOR per cell survived. In the multivariate analysis, only AgNOR count retained an independent prognostic significance.
Prognostic value of AgNOR counting. A prospective study in a series of renal cell carcinomas.
PICH, Achille;
1997-01-01
Abstract
A prospective study was performed in 21 renal cell carcinomas (RCC) to clarify the prognostic role of AgNOR counting. Sections were stained in 1990 with the method of Ploton: the mean AgNOR count for the whole series was 6.13, the median 5.94 amd the SD 1.78. Patients were then followed up for at least 6 years or to death. At the time of analysis (1996), 13 patients were alive, without evidence of recurrence or metastasis, 6 had died of the disease and 2 of myocardial infarction. All the patients with 5.94 AgNOR per cell or fewer were alive, while only 60% of patient with more than 5.94 AgNOR per cell survived. In the multivariate analysis, only AgNOR count retained an independent prognostic significance.
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