Small Ruminant Lentiviruses (SRLV) represent a group of viruses infecting sheep and goats worldwide. Despite the high heterogeneity of genotype A strains which cluster into as many as 10 subtypes, the genotype B was believed to be less complex and has so far been subdivided into only 2 subtypes. Here we describe two novel full-length proviral sequences isolated from Sarda sheep in two Italian regions. Genome sequence as well as the main linear epitopes clearly grouped this cluster into B genotype. However, due to long-lasting segregation of this sheep breed, the genetic distances clearly above 15% in respect to B1 and B2 subtypes, suggest the designation of a novel subtype B3. Moreover the close relationship with gag sequence obtained from a Turkish sheep adds new evidence to historical data suggesting an anthropochorous dissemination of hosts (small ruminants) and their pathogens (SRLV) during the Mediterranean colonization from Middle East.

Characterization of new Small Ruminant Lentivirus subtype B3 suggests animal trade within the Mediterranean Basin.

BERTOLOTTI, Luigi;JUGANARU, MARIA MAGDALENA;ROSATI, Sergio
2011

Abstract

Small Ruminant Lentiviruses (SRLV) represent a group of viruses infecting sheep and goats worldwide. Despite the high heterogeneity of genotype A strains which cluster into as many as 10 subtypes, the genotype B was believed to be less complex and has so far been subdivided into only 2 subtypes. Here we describe two novel full-length proviral sequences isolated from Sarda sheep in two Italian regions. Genome sequence as well as the main linear epitopes clearly grouped this cluster into B genotype. However, due to long-lasting segregation of this sheep breed, the genetic distances clearly above 15% in respect to B1 and B2 subtypes, suggest the designation of a novel subtype B3. Moreover the close relationship with gag sequence obtained from a Turkish sheep adds new evidence to historical data suggesting an anthropochorous dissemination of hosts (small ruminants) and their pathogens (SRLV) during the Mediterranean colonization from Middle East.
92
1923
1929
Bertolotti L; Mazzei M; Puggioni G; Carrozza ML; Dei Giudici S; Muz D; Juganaru MM; Patta C; Tolari F; Rosati S.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/83124
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