Bone marrow biopsies from 40 adult patients with AML were stained with the argyrophilic method for AgNORs.The mean AgNOR count for the whole series was 6.6; it was higher in CR patients than in resistant ones (P = .02). The median duration of CR was 26 months for patients with an AgNOR count greater than 6.6, but only 6 months for those with lower counts (P = .01). In multivariate analysis, AgNOR count appeared as an independent prognostic variable. AgNOR analysis is a simple, inexpensive, and widely available method that offers some advantages over other measures of cell proliferative activity.
Nucleolar organizer region counts predict complete remission, remission duration and survival in adult myelogeneous leukemia patients
PICH, Achille;
2000-01-01
Abstract
Bone marrow biopsies from 40 adult patients with AML were stained with the argyrophilic method for AgNORs.The mean AgNOR count for the whole series was 6.6; it was higher in CR patients than in resistant ones (P = .02). The median duration of CR was 26 months for patients with an AgNOR count greater than 6.6, but only 6 months for those with lower counts (P = .01). In multivariate analysis, AgNOR count appeared as an independent prognostic variable. AgNOR analysis is a simple, inexpensive, and widely available method that offers some advantages over other measures of cell proliferative activity.
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