Malignant melanoma is fatal in its metastatic stage. It is therefore essential to unravel the molecular mechanisms that govern disease progression to metastasis. MicroRNAs (miRs) are endogenous non-coding RNAs involved in tumourigenesis. Using a melanoma progression model, we identified a novel pathway controlled by miR-214 that coordinates metastatic capability. Pathway components include TFAP2C, homologue of a well-established melanoma tumour suppressor, the adhesion receptor ITGA3 and multiple surface molecules. Modulation of miR-214 influences in vitro tumour cell movement and survival to anoikis as well as extravasation from blood vessels and lung metastasis formation in vivo. Considering that miR-214 is known to be highly expressed in human melanomas, our data suggest a critical role for this miRNA in disease progression and the establishment of distant metastases.

microRNA-214 contributes to melanoma tumor progression through suppression of TFAP2C

PENNA, ELISA;ORSO, FRANCESCA;CIMINO, DANIELA;LEMBO, ANTONIO;QUAGLINO, Elena;OSELLA ABATE, Simona;PINATEL, EVA MARIA;PROVERO, Paolo;BERNENGO, Maria Grazia;TAVERNA, Daniela
2011-01-01

Abstract

Malignant melanoma is fatal in its metastatic stage. It is therefore essential to unravel the molecular mechanisms that govern disease progression to metastasis. MicroRNAs (miRs) are endogenous non-coding RNAs involved in tumourigenesis. Using a melanoma progression model, we identified a novel pathway controlled by miR-214 that coordinates metastatic capability. Pathway components include TFAP2C, homologue of a well-established melanoma tumour suppressor, the adhesion receptor ITGA3 and multiple surface molecules. Modulation of miR-214 influences in vitro tumour cell movement and survival to anoikis as well as extravasation from blood vessels and lung metastasis formation in vivo. Considering that miR-214 is known to be highly expressed in human melanomas, our data suggest a critical role for this miRNA in disease progression and the establishment of distant metastases.
30(10)
1990
2007
microRNA; melanoma; tumor progression; TFAP2C; ITGA3
Elisa Penna*; Francesca Orso*; Daniela Cimino; Enrico Tenaglia; Antonio Lembo; Elena Quaglino; Laura Poliseno; Adele Haimovic; Simona Osella; Cristiano De Pittà; Eva Pinatel; Michael Stadler; Paolo Provero; Maria Grazia Bernengo; Iman Osman; Daniela Taverna
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/86721
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