Triggering of large granular lymphocyte (LGL) Fc receptor with a specific monoclonal antibody (AB8.28) linked to an insoluble matrix induces cell activation, as witnessed by expression of HLA class II (DR and DQ) molecules and interleukin 2 receptor. Moreover, this event is accompanied by a concomitant release of platelet-activating factor by LGL. We conclude that the Fc receptor molecule identified by mAb AB8.28 represents a trigger for LGL activation.
Fc receptor triggering induces expression of surface antigens and release of platelet activating factor in large granular lymphocytes. / MALAVASI F; TETTA C; FUNARO A; BELLONE G; E. FERRERO; COLLI-FRANZONE A; DELLABONA P; RUSCI R; MATERA L; CAMUSSI G; CALIGARIS-CAPPIO F. - In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. - ISSN 0027-8424. - 83 (8)(1986), pp. 2443-2447.