Here, we present a unifying hypothesis about how messenger RNAs, transcribed pseudogenes, and long noncoding RNAs "talk" to each other using microRNA response elements (MREs) as letters of a new language. We propose that this "competing endogenous RNA" (ceRNA) activity forms a large-scale regulatory network across the transcriptome, greatly expanding the functional genetic information in the human genome and playing important roles in pathological conditions, such as cancer.

A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?

PANDOLFI DE RINALDIS, Pier Paolo
2011

Abstract

Here, we present a unifying hypothesis about how messenger RNAs, transcribed pseudogenes, and long noncoding RNAs "talk" to each other using microRNA response elements (MREs) as letters of a new language. We propose that this "competing endogenous RNA" (ceRNA) activity forms a large-scale regulatory network across the transcriptome, greatly expanding the functional genetic information in the human genome and playing important roles in pathological conditions, such as cancer.
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http://dx.doi.org/10.1016/j.cell.2011.07.014
http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WSN-53DPWJX-2-1&_cdi=7051&_user=525216&_pii=S0092867411008129&_origin=&_coverDate=08%2F05%2F2011&_sk=998539996&view=c&wchp=dGLzVlb-zSkWW&md5=098ef890694653c1c4c9d5e5ba0d5855&ie=/sdarticle.pdf
Salmena L; Poliseno L; Tay Y; Kats L; Pandolfi PP
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/88774
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