INTRODUCTION: Bleomycin-induced pneumonitis (BIP) is a scarcely manageable pulmonary toxicity that occurs in approximately 20% of patients who are affected with cancers that are treated with bleomycin-containing regimens. Generally, the clinical picture is extremely complicated and therapy is based on steroids. The overall response rate to such therapy is limited. Recent insights in BIP pathogenesis have indicated that a key feature is deregulated mechanisms of tissue repair that are driven by profibrotic cytokines. Here we describe a patient with life-threatening BIP who was completely cured with imatinib mesylate (IM) after steroids and all other therapies had failed

Complete Resolution of Life-Threatening Bleomycin-Induced Pneumonitis After Treatment With Imatinib Mesylate in a Patient With Hodgkin's Lymphoma: Hope for Severe Chemotherapy-Induced Toxicity?

SANGIOLO, Dario;D'Ambrosio L;AGLIETTA, Massimo;
2011-01-01

Abstract

INTRODUCTION: Bleomycin-induced pneumonitis (BIP) is a scarcely manageable pulmonary toxicity that occurs in approximately 20% of patients who are affected with cancers that are treated with bleomycin-containing regimens. Generally, the clinical picture is extremely complicated and therapy is based on steroids. The overall response rate to such therapy is limited. Recent insights in BIP pathogenesis have indicated that a key feature is deregulated mechanisms of tissue repair that are driven by profibrotic cytokines. Here we describe a patient with life-threatening BIP who was completely cured with imatinib mesylate (IM) after steroids and all other therapies had failed
Aug 20;29
24e
691
693
Imatinib Mesylate; Bleomycin-induced pneumonitis; pulmonary toxicity
Carnevale-Schianca F; Gallo S; Rota-Scalabrini D; Sangiolo D; Fizzotti M; Caravelli D; Capaldi A; Anselmetti G; Palesandro E; D'Ambrosio L; Coha V; Obert R; Aglietta M; Grignani G.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/89956
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