This study aimed to compare the caspofungin immunomodulating activities against Candida albicans on polymorphonuclear cells (PMNs) from renal transplant recipients (RTRs) and healthy subjects (HSs). RTR PMNs showed a significantly reduced fungicidal activity compared with that of HS PMNs. Addition of caspofungin to RTR PMNs significantly potentiated the yeast intracellular killing rate, achieving values similar to those observed for HS PMNs. These data show that caspofungin is suitable for invasive candidiasis treatment in patients with immune system-impaired components.
Candida albicans infections in renal transplant recipients: effect of caspofungin on polymorphonuclear cells.
ALLIZOND, VALERIA;BANCHE, Giuliana;MERLINO, Chiara;TULLIO, Viviana Cristina;SCALAS, Daniela;MANDRAS, Narcisa;ROANA, Janira;CUFFINI, Annamaria
2011-01-01
Abstract
This study aimed to compare the caspofungin immunomodulating activities against Candida albicans on polymorphonuclear cells (PMNs) from renal transplant recipients (RTRs) and healthy subjects (HSs). RTR PMNs showed a significantly reduced fungicidal activity compared with that of HS PMNs. Addition of caspofungin to RTR PMNs significantly potentiated the yeast intracellular killing rate, achieving values similar to those observed for HS PMNs. These data show that caspofungin is suitable for invasive candidiasis treatment in patients with immune system-impaired components.
File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
AAC 2011 Allizond.pdf
Accesso aperto
Tipo di file:
PDF EDITORIALE
Dimensione
136.86 kB
Formato
Adobe PDF
|
136.86 kB | Adobe PDF | Visualizza/Apri |
|
AAC 2011 Allizond.pdf
Accesso riservato
Descrizione: articolo prinicpale
Tipo di file:
PDF EDITORIALE
Dimensione
136.86 kB
Formato
Adobe PDF
|
136.86 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
