This study aimed to compare the caspofungin immunomodulating activities against Candida albicans on polymorphonuclear cells (PMNs) from renal transplant recipients (RTRs) and healthy subjects (HSs). RTR PMNs showed a significantly reduced fungicidal activity compared with that of HS PMNs. Addition of caspofungin to RTR PMNs significantly potentiated the yeast intracellular killing rate, achieving values similar to those observed for HS PMNs. These data show that caspofungin is suitable for invasive candidiasis treatment in patients with immune system-impaired components.

Candida albicans infections in renal transplant recipients: effect of caspofungin on polymorphonuclear cells.

ALLIZOND, VALERIA;BANCHE, Giuliana;MERLINO, Chiara;TULLIO, Viviana Cristina;SCALAS, Daniela;MANDRAS, Narcisa;ROANA, Janira;CUFFINI, Annamaria
2011

Abstract

This study aimed to compare the caspofungin immunomodulating activities against Candida albicans on polymorphonuclear cells (PMNs) from renal transplant recipients (RTRs) and healthy subjects (HSs). RTR PMNs showed a significantly reduced fungicidal activity compared with that of HS PMNs. Addition of caspofungin to RTR PMNs significantly potentiated the yeast intracellular killing rate, achieving values similar to those observed for HS PMNs. These data show that caspofungin is suitable for invasive candidiasis treatment in patients with immune system-impaired components.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
55
12
5936
5938
http://aac.asm.org/content/55/12/5936.long
PMNs; phagocytosis; intracellular killing; Candida albicans; caspofungin
Allizond V; Banche G; Giacchino G; Merlino C; Tullio V; Scalas D; Garneri G; Mandras N; Roana J; Cuffini AM
File in questo prodotto:
File Dimensione Formato  
AAC 2011 Allizond.pdf

accesso aperto

Tipo di file: PDF EDITORIALE
Dimensione 136.86 kB
Formato Adobe PDF
136.86 kB Adobe PDF Visualizza/Apri
AAC 2011 Allizond.pdf

non disponibili

Descrizione: articolo prinicpale
Tipo di file: PDF EDITORIALE
Dimensione 136.86 kB
Formato Adobe PDF
136.86 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/90079
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 3
social impact