Nanobubbles consisting of a diethylaminoethyl-dextran (DEAE) shell and a perfluoropentane core were prepared as a novel DNA transfection agent. Nanobubble diameters were less than 500 nm, they possessed positive surface charge, and the ability to complex with and transfect DNA. DEAE nanobubbles present a novel platform for DNA delivery into cells that may be combined with ultrasound for imaging and targeting purposes.
The in vitro characterization of dextran-based nanobubbles as possible DNA transfection agents
BISAZZA, AGNESE;CIVRA, ANDREA;DONALISIO, Manuela;LEMBO, David;CAVALLI, Roberta
2011-01-01
Abstract
Nanobubbles consisting of a diethylaminoethyl-dextran (DEAE) shell and a perfluoropentane core were prepared as a novel DNA transfection agent. Nanobubble diameters were less than 500 nm, they possessed positive surface charge, and the ability to complex with and transfect DNA. DEAE nanobubbles present a novel platform for DNA delivery into cells that may be combined with ultrasound for imaging and targeting purposes.
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