The assembly of molecular hubs upon integrin and growth factor stimulation represents a preferential way to transduce signals throughout the cell. Among the intracellular kinases that are responsive to integrin and growth factor activation, Src Family Kinases (SFKs) are crucial regulators of cell migration and invasion. Increasing evidence highlight the importance of adaptor proteins in these processes, based on their ability to create signalling platforms that control downstream signals. Among these adaptors we will discuss the molecular features of p130Cas and p140Cap proteins in terms of regulation of cell migration and invasion in normal and transformed cells.

The adaptor proteins p140CAP and p130CAS as molecular hubs in cell migration and invasion of cancer cells.

DI STEFANO, PAOLA;CAMACHO LEAL, MARIA del PILAR;TORNILLO, GIUSY;BISARO, Brigitte;REPETTO, DANIELE;PINCINI, ALESSANDRA;SHARMA, Hanjabam Nanaocha;TURCO, Emilia;CABODI, Sara;DEFILIPPI, Paola
2011

Abstract

The assembly of molecular hubs upon integrin and growth factor stimulation represents a preferential way to transduce signals throughout the cell. Among the intracellular kinases that are responsive to integrin and growth factor activation, Src Family Kinases (SFKs) are crucial regulators of cell migration and invasion. Increasing evidence highlight the importance of adaptor proteins in these processes, based on their ability to create signalling platforms that control downstream signals. Among these adaptors we will discuss the molecular features of p130Cas and p140Cap proteins in terms of regulation of cell migration and invasion in normal and transformed cells.
5
663
673
http://www.ajcr.us
p130Cas; p140Cap; breast cancer
Di Stefano P; Leal MP; Tornillo G; Bisaro B; Repetto D; Pincini A; Santopietro E; Sharma N; Turco E; Cabodi S; Defilippi P.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/92982
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