Anaplastic large-cell lymphoma

Inghirami, Giorgio; Pileri, Sa; Chiarle, Roberto; Cuccuru, G; Martinoglio, B; Medico, Enzo; Pellegrino, Elisa; Piva, Roberto; Ruberto, Ml; Fornari, A; Novero, D; Chilosi, M; Zamó, A; Facchetti, F; Lonardi, S; De Chiara, A; Fulciniti, F; Doglioni, C; Ponzoni, M; Agnelli, L; Neri, A; Todoerti, K; Agostinelli, C; Piccaluga, Pp; Falini, B; Tiacci, E; Van Loo, P; Tousseyn, T; De Wolf Peeters, C; Geissinger, E; Muller Hermelink HK,; Rosenwald, A; Piris, Ma; Rodriguez, M. E.

doi:10.1053/j.semdp.2011.03.002

The concept of anaplastic large-cell lymphoma (ALCL) has changed over the years because of a stream of new information and novel understanding regarding the cell of origin, biology, genetics, and clinical features of these neoplasms. This new information has led to the current classification proposed by the expert reviewers of the World Health Organization. The objective of this review is to present the most updated information on the cytologic and histologic features of these entities, with a special reference to diagnostic algorithms. A detailed description of the genetic aberrations and the pathogenetic mechanisms leading to transformation is presented. The clinical features of ALCL and novel tailored strategies are briefly illustrated.

Titolo:	Anaplastic large-cell lymphoma
Autori Riconosciuti:	INGHIRAMI, Giorgio Pileri SA CHIARLE, Roberto Cuccuru G Martinoglio B MEDICO, Enzo PELLEGRINO, Elisa PIVA, Roberto Ruberto ML Fornari A Novero D Chilosi M ZAMO', Alberto Facchetti F Lonardi S De Chiara A Fulciniti F Doglioni C Ponzoni M Agnelli L Neri A Todoerti K Agostinelli C Piccaluga PP Falini B Tiacci E Van Loo P Tousseyn T De Wolf Peeters C Geissinger E Muller Hermelink HK Rosenwald A Piris MA Rodriguez M.E. mostra contributor esterni nascondi contributor esterni
Autori:	Inghirami G; Pileri SA; Chiarle R; Cuccuru G; Martinoglio B; Medico E; Pellegrino E; Piva R; Ruberto ML; Fornari A; Novero D; Chilosi M; Zamó A; Facchetti F; Lonardi S; De Chiara A; Fulciniti F; Doglioni C; Ponzoni M; Agnelli L; Neri A; Todoerti K; Agostinelli C; Piccaluga PP; Falini B; Tiacci E; Van Loo P; Tousseyn T; De Wolf-Peeters C; Geissinger E; Muller-Hermelink HK; Rosenwald A; Piris MA; Rodriguez ME.
Data di pubblicazione:	2011
Abstract:	The concept of anaplastic large-cell lymphoma (ALCL) has changed over the years because of a stream of new information and novel understanding regarding the cell of origin, biology, genetics, and clinical features of these neoplasms. This new information has led to the current classification proposed by the expert reviewers of the World Health Organization. The objective of this review is to present the most updated information on the cytologic and histologic features of these entities, with a special reference to diagnostic algorithms. A detailed description of the genetic aberrations and the pathogenetic mechanisms leading to transformation is presented. The clinical features of ALCL and novel tailored strategies are briefly illustrated.
Volume:	28
Fascicolo:	3
Pagina iniziale:	190
Pagina finale:	201
Digital Object Identifier (DOI):	10.1053/j.semdp.2011.03.002
URL:	http:// http://www.sciencedirect.com/science/journal/07402570
Parole Chiave:	Anaplastic large-cell lymphoma (ALCL); Peripheral T-cell lymphoma (PTCL); Phenotype; Immunohistochemistry; Molecular biology; Targeted therapy; Anaplastic lymphoma kinase (ALK); Chimeric fusion proteins; Signaling pathways
Rivista:	SEMINARS IN DIAGNOSTIC PATHOLOGY
Appare nelle tipologie:	03B-Review in Rivista / Rassegna della Lett. in Riv. / Nota Critica

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