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EnglishThe concept of anaplastic large-cell lymphoma (ALCL) has changed over the years because of a stream of new information and novel understanding regarding the cell of origin, biology, genetics, and clinical features of these neoplasms. This new information has led to the current classification proposed by the expert reviewers of the World Health Organization. The objective of this review is to present the most updated information on the cytologic and histologic features of these entities, with a special reference to diagnostic algorithms. A detailed description of the genetic aberrations and the pathogenetic mechanisms leading to transformation is presented. The clinical features of ALCL and novel tailored strategies are briefly illustrated.
Anaplastic large-cell lymphoma / Inghirami G; Pileri SA; Chiarle R; Cuccuru G; Martinoglio B; Medico E; Pellegrino E; Piva R; Ruberto ML; Fornari A; Novero D; Chilosi M; Zamó A; Facchetti F; Lonardi S; De Chiara A; Fulciniti F; Doglioni C; Ponzoni M; Agnelli L; Neri A; Todoerti K; Agostinelli C; Piccaluga PP; Falini B; Tiacci E; Van Loo P; Tousseyn T; De Wolf-Peeters C; Geissinger E; Muller-Hermelink HK; Rosenwald A; Piris MA; Rodriguez ME.. - In: SEMINARS IN DIAGNOSTIC PATHOLOGY. - ISSN 0740-2570. - 28:3(2011), pp. 190-201.
| Titolo: | Anaplastic large-cell lymphoma |
| Autori Riconosciuti: | |
| Autori: | Inghirami G; Pileri SA; Chiarle R; Cuccuru G; Martinoglio B; Medico E; Pellegrino E; Piva R; Ruberto ML; Fornari A; Novero D; Chilosi M; Zamó A; Facchetti F; Lonardi S; De Chiara A; Fulciniti F; Doglioni C; Ponzoni M; Agnelli L; Neri A; Todoerti K; Agostinelli C; Piccaluga PP; Falini B; Tiacci E; Van Loo P; Tousseyn T; De Wolf-Peeters C; Geissinger E; Muller-Hermelink HK; Rosenwald A; Piris MA; Rodriguez ME. |
| Data di pubblicazione: | 2011 |
| Abstract: | The concept of anaplastic large-cell lymphoma (ALCL) has changed over the years because of a stream of new information and novel understanding regarding the cell of origin, biology, genetics, and clinical features of these neoplasms. This new information has led to the current classification proposed by the expert reviewers of the World Health Organization. The objective of this review is to present the most updated information on the cytologic and histologic features of these entities, with a special reference to diagnostic algorithms. A detailed description of the genetic aberrations and the pathogenetic mechanisms leading to transformation is presented. The clinical features of ALCL and novel tailored strategies are briefly illustrated. |
| Volume: | 28 |
| Fascicolo: | 3 |
| Pagina iniziale: | 190 |
| Pagina finale: | 201 |
| Digital Object Identifier (DOI): | 10.1053/j.semdp.2011.03.002 |
| URL: | http:// http://www.sciencedirect.com/science/journal/07402570 |
| Parole Chiave: | Anaplastic large-cell lymphoma (ALCL); Peripheral T-cell lymphoma (PTCL); Phenotype; Immunohistochemistry; Molecular biology; Targeted therapy; Anaplastic lymphoma kinase (ALK); Chimeric fusion proteins; Signaling pathways |
| Rivista: | SEMINARS IN DIAGNOSTIC PATHOLOGY |
| Appare nelle tipologie: | 03B-Review in Rivista / Rassegna della Lett. in Riv. / Nota Critica |
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