Blood vessels sprout toward avascular tissue in response to attractive proangiogenic factors. However, restricting signals are also required to coordinate the behavior of endothelial cells assembling the vascular network. Semaphorin cues are at the crossroad of this traffic, and they direct the behavior of endothelial tip cells leading the way.
Semaphorin signals on the road of endothelial tip cells.
TAMAGNONE, Luca;Mazzone M.
2011-01-01
Abstract
Blood vessels sprout toward avascular tissue in response to attractive proangiogenic factors. However, restricting signals are also required to coordinate the behavior of endothelial cells assembling the vascular network. Semaphorin cues are at the crossroad of this traffic, and they direct the behavior of endothelial tip cells leading the way.
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