The receptor tyrosine kinases (RTKs) play a critical role, controlling cell proliferation, survival, and differentiation of normal cells. Their pivotal function has been firmly established in the pathogenesis of many cancers as well. The anaplastic lymphoma kinase (ALK), a transmembrane RTK, originally identified in the nucleophosmin (NPM)–ALK chimera of anaplastic large cell lymphoma, has emerged as a novel tumorigenic player in several human cancers. In this review, we describe the expression of the ALK–RTK, its related fusion proteins, and their molecular mechanisms of activation. Novel tailored strategies are briefly illustrated for the treatment of ALK-positive neoplasms.

Anaplastic lymphoma kinase in human cancer

Barreca A;Lasorsa E;Riera L;Piva R;Inghirami G;Chiarle R
Membro del Collaboration Group
;
Pellegrino E
Membro del Collaboration Group
;
Voena C
Membro del Collaboration Group
;
2011-01-01

Abstract

The receptor tyrosine kinases (RTKs) play a critical role, controlling cell proliferation, survival, and differentiation of normal cells. Their pivotal function has been firmly established in the pathogenesis of many cancers as well. The anaplastic lymphoma kinase (ALK), a transmembrane RTK, originally identified in the nucleophosmin (NPM)–ALK chimera of anaplastic large cell lymphoma, has emerged as a novel tumorigenic player in several human cancers. In this review, we describe the expression of the ALK–RTK, its related fusion proteins, and their molecular mechanisms of activation. Novel tailored strategies are briefly illustrated for the treatment of ALK-positive neoplasms.
2011
47
1
11
23
http://jme.endocrinology-journals.org/content/47/1/R11.long
Barreca A; Lasorsa E; Riera L; Machiorlatti R; Piva R; Ponzoni M; Kwee I; Bertoni F; Piccaluga PP; Pileri SA; Inghirami G; European T-Cell Lymphoma Study Group; Barreca A; Chiarle R; Cuccuru G; Inghirami G; Martinoglio B; Medico E; Pellegrino E; Piva R; Ruberto ML; Voena C; Fornari A; Novero D; Chilosi M; Zamò A; Facchetti F; Lonardi S; De Chiara A; Fulciniti F; Doglioni C; Ponzoni M; Agnelli L; Neri A; Todoerti K; Piccaluga PP; Pileri S; Falini B; Tiacci E; Van Loo P; Tousseyn T; De Wolf-Peeters C; Geissinger E; Konrad Muller-Hermelink H; Rosenwald A; Piris MA; Rodriguez ME
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/94605
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