Integrin signaling has a critical function in organizing cells in tissues during both embryonic development and tissue repair. Following their binding to the extracellular ligands, the intracellular signaling pathways triggered by integrins are directed to two major functions: organization of the actin cytoskeleton and regulation of cell behaviour including survival, differentiation and growth. Basic research conducted in the past twelve years has lead to remarkable breakthroughs in this field. Integrins are catalytically inactive and translate positional cues into biochemical signals by direct and/or functional association with intracellular adaptors, cytosolic tyrosine kinases or growth factor and cytokine receptors. The purpose of this chapter is to highlight recent experimental and conceptual advances in integrin signaling with particular emphasis on the ability of integrins to regulate Fak/Src family kinases (SFKs) activation and the cross-talk with soluble growth factors receptors and cytokines

Integrins and Signal Transduction

CABODI, Sara;DI STEFANO, PAOLA;CAMACHO LEAL, MARIA del PILAR;BISARO, Brigitte;MORELLO, Virginia;DAMIANO, Laura;ARAMU, SIMONA;REPETTO, DANIELE;TORNILLO, GIUSY;DEFILIPPI, Paola
2010

Abstract

Integrin signaling has a critical function in organizing cells in tissues during both embryonic development and tissue repair. Following their binding to the extracellular ligands, the intracellular signaling pathways triggered by integrins are directed to two major functions: organization of the actin cytoskeleton and regulation of cell behaviour including survival, differentiation and growth. Basic research conducted in the past twelve years has lead to remarkable breakthroughs in this field. Integrins are catalytically inactive and translate positional cues into biochemical signals by direct and/or functional association with intracellular adaptors, cytosolic tyrosine kinases or growth factor and cytokine receptors. The purpose of this chapter is to highlight recent experimental and conceptual advances in integrin signaling with particular emphasis on the ability of integrins to regulate Fak/Src family kinases (SFKs) activation and the cross-talk with soluble growth factors receptors and cytokines
Integrins and ion channels
Landes Bioscence
674
43
54
9781441960658
Sara Cabodi; Paola Di Stefano; Maria del Pilar Camacho Leal; Agata Tinnirello; Brigitte Bisaro; Virginia Morello; Laura Damiano; Simona Aramu; Daniele Repetto; Giusy Tornillo; Paola Defilippi
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/97402
Citazioni
  • ???jsp.display-item.citation.pmc??? 59
  • Scopus 106
  • ???jsp.display-item.citation.isi??? 93
social impact