CIRCOSTA, Paola

CIRCOSTA, Paola  

SCIENZE CLINICHE E BIOLOGICHE  

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Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity 2006 PETRELLI A; CIRCOSTA P; GRANZIERO L; MAZZONE M; PISACANE A; FENOGLIO S; COMOGLIO P; GIORDANO S
Apoptotic and differentiating therapy for AML using potent human dihydroorotate dehydrogenase inhibitor 2021 Sainas Sainas, Circosta Paola, Pippione Agnese Chiara, Giorgis Marta, Marraudino Marilena, Houshmand Mohammad, Bonaldo Brigitta, Gaidano Valentina, Cignetti Alessandro, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lolli
CD100/Plexin-B1 interactions sustain proliferation and survival of normal and Leukemic CD5+ B lymphocytes 2003 GRNAZIERO L; CIRCOSTA P; SCIELZO C; FRISALDI E; STELLA S; GEUNA M; S. GIORDANO; GHIA P; CALIGARIS CAPPIO F
Clonal CD8+ TCR-Vbeta expanded populations with effector memory phenotype in Churg Strauss syndrome 2008 Giuseppe Guida; Antonella Vallario; Stefania Stella; Monica Boita; Paola Circosta; Sara Mariani; Giuseppina Prato; Enrico Heffler; Roberta Bergia; Antonino Sottile; Giovanni Rolla; Alessandro Cignetti
Cytokine-induced killer cells engineered with exogenous t-cell receptors directed against melanoma antigens: Enhanced efficacy of effector cells endowed with a double mechanism of tumor recognition 2015 Elia, Angela R; Circosta, Paola; Sangiolo, Dario; Bonini, Chiara; Gammaitoni, Loretta; Mastaglio, Sara; Genovese, Pietro; Geuna, Massimo; Avolio, Fabio; Inghirami, Giorgio; Tarella, Corrado; Cignetti, Alessandro
Development of Potent Human Dihydroorotate Dehydrogenase Inhibitors Able to Induces Myeloid Differentiation 2018 Stefano Sainas, Agnese C. Pippione, Davide Bonanni, Marta Giorgis, Elisa Lupino, Enrico Giraudo, Paola Circosta, Valentina Gaidano, Alessandro Cignetti, Marco Piccinini, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco L. Lolli
DHODH inhibitors and leukemia: an emergent interest for new myeloid differentiation agents 2018 Sainas, S; Pippione, AC; Boschi, D; Gaidano, V; Circosta, P; Cignetti, A; Dosio, F; Lolli, ML
Differential effects on CLL cell survival exerted by different microenvironmental elements. 2005 Ghia P; Circosta P; Scielzo C; Vallario A; Camporeale A; Granziero L; Caligaris-Cappio F
A differentiating and apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor 2021 Stefano Sainas, Paola Circosta, Marta Giorgis, Agnese Chiara Pippione, Marilena Marraudino, Mohammad Houshmand, Brigitta Bonaldo, Valentina Gaidano, Alessandro Cignetti, Stefano Gotti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli
A differentiating and apoptotic therapy for acute myeloid leukaemia using potent human dihydroorotate dehydrogenase inhibitors. 2019 Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Marilena Marraudino, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli
Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia 2022 Houshmand, Mohammad; Vitale, Nicoletta; Orso, Francesca; Cignetti, Alessandro; Molineris, Ivan; Gaidano, Valentina; Sainas, Stefano; Giorgis, Marta; Boschi, Donatella; Fava, Carmen; Passoni, Alice; Gai, Marta; Geuna, Massimo; Sora, Federica; Iurlo, Alessandra; Abruzzese, Elisabetta; Breccia, Massimo; Mulas, Olga; Caocci, Giovanni; Castagnetti, Fausto; Taverna, Daniela; Oliviero, Salvatore; Pane, Fabrizio; Lolli, Marco Lucio; Circosta, Paola; Saglio, Giuseppe
Emerging therapies for acute myeloid leukaemia using hDHODH inhibitors 2019 Sainas Stefano, Pippione Agnese Chiara, Bonanni Davide, Giorgis Marta, Lupino Elisa, Circosta Paola, Gaidano Valentina, Cignetti Alessandro, Piccinini Marco, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lucio
Emerging therapies for acute myeloid leukaemia using hDHODH inhibitors able to restore in vitro and in vivo myeloid differentiation 2019 Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Marilena Marraudino, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli
Full chimaeric CAR.CIK from patients engrafted after allogeneic haematopoietic cell transplant: Feasibility, anti-leukaemic potential and alloreactivity across major human leukocyte antigen barriers 2022 Circosta, Paola; Donini, Chiara; Gallo, Susanna; Giraudo, Lidia; Gammaitoni, Loretta; Rotolo, Ramona; Galvagno, Federica; Capellero, Sonia; Basiricò, Marco; Casucci, Monica; Aglietta, Massimo; Ferrero, Ivana; Fagioli, Franca; Cignetti, Alessandro; Carnevale-Schianca, Fabrizio; Leuci, Valeria; Sangiolo, Dario
Functional phenotype of peripheral lymphocytes in Churg Strauss syndrome 2012 Boita, M; Guida, G; Circosta, P; Heffler, E; Stella, S; Elia, A; Geuna, M; Rolla, G; Cignetti, A
High basal γH2AX levels sustain self-renewal of mouse embryonic and induced pluripotent stem cells 2012 Turinetto, Valentina; Orlando, Luca; Sanchez Ripoll, Y.; Kumpfmuller, B.; Porcedda, P.; Minieri, Valentina; Saviozzi, Silvia; Accomasso, Lisa; CIBRARIO ROCCHIETTI, Elisa; Circosta, Paola; Cignetti, A.; Welham, M. J.; Giachino, Claudia
High Basal γH2AX Levels Sustain Self-Renewal of Mouse Embryonic and Induced Pluripotent Stem Cells. 2012 Turinetto V; Orlando L; Sanchez-Ripoll Y; Kumpfmueller B; Storm MP; Porcedda P; Minieri V; Saviozzi S; Accomasso L; Rocchietti EC; Moorwood K; Circosta P; Cignetti A; Welham MJ; Giachino C.
Hydroxylated heterocycles as a bioisosteric tool to Modulate the carboxylic function into design potent human Dihydroorotate Dehydrogenase inhibitors 2021 Stefano Sainas, Paola Circosta, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli
Identification of a new subclass of ALK negative ALCL expressing aberrant levels of ERBB4 transcripts 2016 Scarfo', Irene; Pellegrino, Elisa; Mereu, Elisabetta; Kwee, Ivo; Agnelli, Luca; Bergaggio, Elisa; Garaffo, Giulia; Vitale, Nicoletta; Caputo, Manuel; Machiorlatti, Rodolfo; Circosta, Paola; Abate, Francesco; Barreca, Antonella; Novero, Domenico; Mathew, Susan; Rinaldi, Andrea; Tiacci, Enrico; Serra, Sara; Deaglio, Silvia; Neri, Antonino; Falini, Brunanagelo; Rabadan, Raul; Bertoni, Francesco; Inghirami, Giorgio; Piva, Roberto
Improvement of in vivo pharmacokinetic profile of M433, a potent and innovative hDHODH inhibitor. 2019 Marta Alberti, Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli