CIRCOSTA, Paola
CIRCOSTA, Paola
SCIENZE CLINICHE E BIOLOGICHE
A differentiating and apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor
2021-01-01 Stefano Sainas, Paola Circosta, Marta Giorgis, Agnese Chiara Pippione, Marilena Marraudino, Mohammad Houshmand, Brigitta Bonaldo, Valentina Gaidano, Alessandro Cignetti, Stefano Gotti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli
A differentiating and apoptotic therapy for acute myeloid leukaemia using potent human dihydroorotate dehydrogenase inhibitors.
2019-01-01 Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Marilena Marraudino, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli
A new pro-apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor
2021-01-01 Sainas Sainas, Paola Circosta, Noemi Villella, Elena Martino, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Caterina Peraldo Neia, Giovanna Chiorino, Salam Al-Karadaghi, Donatella Boschi, Giuseppe Saglio, Marco Lucio Lolli.
Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity
2006-01-01 PETRELLI A; CIRCOSTA P; GRANZIERO L; MAZZONE M; PISACANE A; FENOGLIO S; COMOGLIO P; GIORDANO S
Apoptotic and differentiating therapy for AML using potent human dihydroorotate dehydrogenase inhibitor
2021-01-01 Sainas Sainas, Circosta Paola, Pippione Agnese Chiara, Giorgis Marta, Marraudino Marilena, Houshmand Mohammad, Bonaldo Brigitta, Gaidano Valentina, Cignetti Alessandro, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lolli
CD100/Plexin-B1 interactions sustain proliferation and survival of normal and Leukemic CD5+ B lymphocytes
2003-01-01 GRNAZIERO L; CIRCOSTA P; SCIELZO C; FRISALDI E; STELLA S; GEUNA M; S. GIORDANO; GHIA P; CALIGARIS CAPPIO F
Clonal CD8+ TCR-Vbeta expanded populations with effector memory phenotype in Churg Strauss syndrome
2008-01-01 Giuseppe Guida; Antonella Vallario; Stefania Stella; Monica Boita; Paola Circosta; Sara Mariani; Giuseppina Prato; Enrico Heffler; Roberta Bergia; Antonino Sottile; Giovanni Rolla; Alessandro Cignetti
Cytokine-induced killer cells engineered with exogenous t-cell receptors directed against melanoma antigens: Enhanced efficacy of effector cells endowed with a double mechanism of tumor recognition
2015-01-01 Elia, Angela R; Circosta, Paola; Sangiolo, Dario; Bonini, Chiara; Gammaitoni, Loretta; Mastaglio, Sara; Genovese, Pietro; Geuna, Massimo; Avolio, Fabio; Inghirami, Giorgio; Tarella, Corrado; Cignetti, Alessandro
Development of Potent Human Dihydroorotate Dehydrogenase Inhibitors Able to Induces Myeloid Differentiation
2018-01-01 Stefano Sainas, Agnese C. Pippione, Davide Bonanni, Marta Giorgis, Elisa Lupino, Enrico Giraudo, Paola Circosta, Valentina Gaidano, Alessandro Cignetti, Marco Piccinini, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco L. Lolli
DHODH inhibitors and leukemia: an emergent interest for new myeloid differentiation agents
2018-01-01 Sainas, S; Pippione, AC; Boschi, D; Gaidano, V; Circosta, P; Cignetti, A; Dosio, F; Lolli, ML
Differential effects on CLL cell survival exerted by different microenvironmental elements.
2005-01-01 Ghia P; Circosta P; Scielzo C; Vallario A; Camporeale A; Granziero L; Caligaris-Cappio F
Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia
2022-01-01 Houshmand, Mohammad; Vitale, Nicoletta; Orso, Francesca; Cignetti, Alessandro; Molineris, Ivan; Gaidano, Valentina; Sainas, Stefano; Giorgis, Marta; Boschi, Donatella; Fava, Carmen; Passoni, Alice; Gai, Marta; Geuna, Massimo; Sora, Federica; Iurlo, Alessandra; Abruzzese, Elisabetta; Breccia, Massimo; Mulas, Olga; Caocci, Giovanni; Castagnetti, Fausto; Taverna, Daniela; Oliviero, Salvatore; Pane, Fabrizio; Lolli, Marco Lucio; Circosta, Paola; Saglio, Giuseppe
Emerging therapies for acute myeloid leukaemia using hDHODH inhibitors
2019-01-01 Sainas Stefano, Pippione Agnese Chiara, Bonanni Davide, Giorgis Marta, Lupino Elisa, Circosta Paola, Gaidano Valentina, Cignetti Alessandro, Piccinini Marco, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lucio
Emerging therapies for acute myeloid leukaemia using hDHODH inhibitors able to restore in vitro and in vivo myeloid differentiation
2019-01-01 Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Marilena Marraudino, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli
Full chimaeric CAR.CIK from patients engrafted after allogeneic haematopoietic cell transplant: Feasibility, anti-leukaemic potential and alloreactivity across major human leukocyte antigen barriers
2023-01-01 Circosta, Paola; Donini, Chiara; Gallo, Susanna; Giraudo, Lidia; Gammaitoni, Loretta; Rotolo, Ramona; Galvagno, Federica; Capellero, Sonia; Basiricò, Marco; Casucci, Monica; Aglietta, Massimo; Ferrero, Ivana; Fagioli, Franca; Cignetti, Alessandro; Carnevale-Schianca, Fabrizio; Leuci, Valeria; Sangiolo, Dario
Functional phenotype of peripheral lymphocytes in Churg Strauss syndrome
2012-01-01 Boita, M; Guida, G; Circosta, P; Heffler, E; Stella, S; Elia, A; Geuna, M; Rolla, G; Cignetti, A
High basal γH2AX levels sustain self-renewal of mouse embryonic and induced pluripotent stem cells
2012-01-01 Turinetto, Valentina; Orlando, Luca; Sanchez Ripoll, Y.; Kumpfmuller, B.; Porcedda, P.; Minieri, Valentina; Saviozzi, Silvia; Accomasso, Lisa; CIBRARIO ROCCHIETTI, Elisa; Circosta, Paola; Cignetti, A.; Welham, M. J.; Giachino, Claudia
High Basal γH2AX Levels Sustain Self-Renewal of Mouse Embryonic and Induced Pluripotent Stem Cells.
2012-01-01 Turinetto V; Orlando L; Sanchez-Ripoll Y; Kumpfmueller B; Storm MP; Porcedda P; Minieri V; Saviozzi S; Accomasso L; Rocchietti EC; Moorwood K; Circosta P; Cignetti A; Welham MJ; Giachino C.
Hydroxylated heterocycles as a bioisosteric tool to Modulate the carboxylic function into design potent human Dihydroorotate Dehydrogenase inhibitors
2021-01-01 Stefano Sainas, Paola Circosta, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli
Identification of a new subclass of ALK negative ALCL expressing aberrant levels of ERBB4 transcripts
2016-01-01 Scarfo', Irene; Pellegrino, Elisa; Mereu, Elisabetta; Kwee, Ivo; Agnelli, Luca; Bergaggio, Elisa; Garaffo, Giulia; Vitale, Nicoletta; Caputo, Manuel; Machiorlatti, Rodolfo; Circosta, Paola; Abate, Francesco; Barreca, Antonella; Novero, Domenico; Mathew, Susan; Rinaldi, Andrea; Tiacci, Enrico; Serra, Sara; Deaglio, Silvia; Neri, Antonino; Falini, Brunanagelo; Rabadan, Raul; Bertoni, Francesco; Inghirami, Giorgio; Piva, Roberto
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| A differentiating and apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor | 2021 | Stefano Sainas, Paola Circosta, Marta Giorgis, Agnese Chiara Pippione, Marilena Marraudino, Mohammad Houshmand, Brigitta Bonaldo, Valentina Gaidano, Alessandro Cignetti, Stefano Gotti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli | |
| A differentiating and apoptotic therapy for acute myeloid leukaemia using potent human dihydroorotate dehydrogenase inhibitors. | 2019 | Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Marilena Marraudino, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli | |
| A new pro-apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor | 2021 | Sainas Sainas, Paola Circosta, Noemi Villella, Elena Martino, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Caterina Peraldo Neia, Giovanna Chiorino, Salam Al-Karadaghi, Donatella Boschi, Giuseppe Saglio, Marco Lucio Lolli. | |
| Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity | 2006 | PETRELLI A; CIRCOSTA P; GRANZIERO L; MAZZONE M; PISACANE A; FENOGLIO S; COMOGLIO P; GIORDANO S | |
| Apoptotic and differentiating therapy for AML using potent human dihydroorotate dehydrogenase inhibitor | 2021 | Sainas Sainas, Circosta Paola, Pippione Agnese Chiara, Giorgis Marta, Marraudino Marilena, Houshmand Mohammad, Bonaldo Brigitta, Gaidano Valentina, Cignetti Alessandro, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lolli | |
| CD100/Plexin-B1 interactions sustain proliferation and survival of normal and Leukemic CD5+ B lymphocytes | 2003 | GRNAZIERO L; CIRCOSTA P; SCIELZO C; FRISALDI E; STELLA S; GEUNA M; S. GIORDANO; GHIA P; CALIGARIS CAPPIO F | |
| Clonal CD8+ TCR-Vbeta expanded populations with effector memory phenotype in Churg Strauss syndrome | 2008 | Giuseppe Guida; Antonella Vallario; Stefania Stella; Monica Boita; Paola Circosta; Sara Mariani; Giuseppina Prato; Enrico Heffler; Roberta Bergia; Antonino Sottile; Giovanni Rolla; Alessandro Cignetti | |
| Cytokine-induced killer cells engineered with exogenous t-cell receptors directed against melanoma antigens: Enhanced efficacy of effector cells endowed with a double mechanism of tumor recognition | 2015 | Elia, Angela R; Circosta, Paola; Sangiolo, Dario; Bonini, Chiara; Gammaitoni, Loretta; Mastaglio, Sara; Genovese, Pietro; Geuna, Massimo; Avolio, Fabio; Inghirami, Giorgio; Tarella, Corrado; Cignetti, Alessandro | |
| Development of Potent Human Dihydroorotate Dehydrogenase Inhibitors Able to Induces Myeloid Differentiation | 2018 | Stefano Sainas, Agnese C. Pippione, Davide Bonanni, Marta Giorgis, Elisa Lupino, Enrico Giraudo, Paola Circosta, Valentina Gaidano, Alessandro Cignetti, Marco Piccinini, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco L. Lolli | |
| DHODH inhibitors and leukemia: an emergent interest for new myeloid differentiation agents | 2018 | Sainas, S; Pippione, AC; Boschi, D; Gaidano, V; Circosta, P; Cignetti, A; Dosio, F; Lolli, ML | |
| Differential effects on CLL cell survival exerted by different microenvironmental elements. | 2005 | Ghia P; Circosta P; Scielzo C; Vallario A; Camporeale A; Granziero L; Caligaris-Cappio F | |
| Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia | 2022 | Houshmand, Mohammad; Vitale, Nicoletta; Orso, Francesca; Cignetti, Alessandro; Molineris, Ivan; Gaidano, Valentina; Sainas, Stefano; Giorgis, Marta; Boschi, Donatella; Fava, Carmen; Passoni, Alice; Gai, Marta; Geuna, Massimo; Sora, Federica; Iurlo, Alessandra; Abruzzese, Elisabetta; Breccia, Massimo; Mulas, Olga; Caocci, Giovanni; Castagnetti, Fausto; Taverna, Daniela; Oliviero, Salvatore; Pane, Fabrizio; Lolli, Marco Lucio; Circosta, Paola; Saglio, Giuseppe | |
| Emerging therapies for acute myeloid leukaemia using hDHODH inhibitors | 2019 | Sainas Stefano, Pippione Agnese Chiara, Bonanni Davide, Giorgis Marta, Lupino Elisa, Circosta Paola, Gaidano Valentina, Cignetti Alessandro, Piccinini Marco, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lucio | |
| Emerging therapies for acute myeloid leukaemia using hDHODH inhibitors able to restore in vitro and in vivo myeloid differentiation | 2019 | Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Marilena Marraudino, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli | |
| Full chimaeric CAR.CIK from patients engrafted after allogeneic haematopoietic cell transplant: Feasibility, anti-leukaemic potential and alloreactivity across major human leukocyte antigen barriers | 2023 | Circosta, Paola; Donini, Chiara; Gallo, Susanna; Giraudo, Lidia; Gammaitoni, Loretta; Rotolo, Ramona; Galvagno, Federica; Capellero, Sonia; Basiricò, Marco; Casucci, Monica; Aglietta, Massimo; Ferrero, Ivana; Fagioli, Franca; Cignetti, Alessandro; Carnevale-Schianca, Fabrizio; Leuci, Valeria; Sangiolo, Dario | |
| Functional phenotype of peripheral lymphocytes in Churg Strauss syndrome | 2012 | Boita, M; Guida, G; Circosta, P; Heffler, E; Stella, S; Elia, A; Geuna, M; Rolla, G; Cignetti, A | |
| High basal γH2AX levels sustain self-renewal of mouse embryonic and induced pluripotent stem cells | 2012 | Turinetto, Valentina; Orlando, Luca; Sanchez Ripoll, Y.; Kumpfmuller, B.; Porcedda, P.; Minieri, Valentina; Saviozzi, Silvia; Accomasso, Lisa; CIBRARIO ROCCHIETTI, Elisa; Circosta, Paola; Cignetti, A.; Welham, M. J.; Giachino, Claudia | |
| High Basal γH2AX Levels Sustain Self-Renewal of Mouse Embryonic and Induced Pluripotent Stem Cells. | 2012 | Turinetto V; Orlando L; Sanchez-Ripoll Y; Kumpfmueller B; Storm MP; Porcedda P; Minieri V; Saviozzi S; Accomasso L; Rocchietti EC; Moorwood K; Circosta P; Cignetti A; Welham MJ; Giachino C. | |
| Hydroxylated heterocycles as a bioisosteric tool to Modulate the carboxylic function into design potent human Dihydroorotate Dehydrogenase inhibitors | 2021 | Stefano Sainas, Paola Circosta, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli | |
| Identification of a new subclass of ALK negative ALCL expressing aberrant levels of ERBB4 transcripts | 2016 | Scarfo', Irene; Pellegrino, Elisa; Mereu, Elisabetta; Kwee, Ivo; Agnelli, Luca; Bergaggio, Elisa; Garaffo, Giulia; Vitale, Nicoletta; Caputo, Manuel; Machiorlatti, Rodolfo; Circosta, Paola; Abate, Francesco; Barreca, Antonella; Novero, Domenico; Mathew, Susan; Rinaldi, Andrea; Tiacci, Enrico; Serra, Sara; Deaglio, Silvia; Neri, Antonino; Falini, Brunanagelo; Rabadan, Raul; Bertoni, Francesco; Inghirami, Giorgio; Piva, Roberto |