CIRCOSTA, Paola
CIRCOSTA, Paola
SCIENZE CLINICHE E BIOLOGICHE
A differentiating and apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor
2021-01-01 Stefano Sainas, Paola Circosta, Marta Giorgis, Agnese Chiara Pippione, Marilena Marraudino, Mohammad Houshmand, Brigitta Bonaldo, Valentina Gaidano, Alessandro Cignetti, Stefano Gotti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli
A differentiating and apoptotic therapy for acute myeloid leukaemia using potent human dihydroorotate dehydrogenase inhibitors.
2019-01-01 Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Marilena Marraudino, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli
A new pro-apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor
2021-01-01 Sainas Sainas, Paola Circosta, Noemi Villella, Elena Martino, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Caterina Peraldo Neia, Giovanna Chiorino, Salam Al-Karadaghi, Donatella Boschi, Giuseppe Saglio, Marco Lucio Lolli.
Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity
2006-01-01 PETRELLI A; CIRCOSTA P; GRANZIERO L; MAZZONE M; PISACANE A; FENOGLIO S; COMOGLIO P; GIORDANO S
Apoptotic and differentiating therapy for AML using potent human dihydroorotate dehydrogenase inhibitor
2021-01-01 Sainas Sainas, Circosta Paola, Pippione Agnese Chiara, Giorgis Marta, Marraudino Marilena, Houshmand Mohammad, Bonaldo Brigitta, Gaidano Valentina, Cignetti Alessandro, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lolli
CD100/Plexin-B1 interactions sustain proliferation and survival of normal and Leukemic CD5+ B lymphocytes
2003-01-01 GRNAZIERO L; CIRCOSTA P; SCIELZO C; FRISALDI E; STELLA S; GEUNA M; S. GIORDANO; GHIA P; CALIGARIS CAPPIO F
Clonal CD8+ TCR-Vbeta expanded populations with effector memory phenotype in Churg Strauss syndrome
2008-01-01 Giuseppe Guida; Antonella Vallario; Stefania Stella; Monica Boita; Paola Circosta; Sara Mariani; Giuseppina Prato; Enrico Heffler; Roberta Bergia; Antonino Sottile; Giovanni Rolla; Alessandro Cignetti
Cytokine-induced killer cells engineered with exogenous t-cell receptors directed against melanoma antigens: Enhanced efficacy of effector cells endowed with a double mechanism of tumor recognition
2015-01-01 Elia, Angela R; Circosta, Paola; Sangiolo, Dario; Bonini, Chiara; Gammaitoni, Loretta; Mastaglio, Sara; Genovese, Pietro; Geuna, Massimo; Avolio, Fabio; Inghirami, Giorgio; Tarella, Corrado; Cignetti, Alessandro
Development of Potent Human Dihydroorotate Dehydrogenase Inhibitors Able to Induces Myeloid Differentiation
2018-01-01 Stefano Sainas, Agnese C. Pippione, Davide Bonanni, Marta Giorgis, Elisa Lupino, Enrico Giraudo, Paola Circosta, Valentina Gaidano, Alessandro Cignetti, Marco Piccinini, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco L. Lolli
DHODH inhibitors and leukemia: an emergent interest for new myeloid differentiation agents
2018-01-01 Sainas, S; Pippione, AC; Boschi, D; Gaidano, V; Circosta, P; Cignetti, A; Dosio, F; Lolli, ML
Differential effects on CLL cell survival exerted by different microenvironmental elements.
2005-01-01 Ghia P; Circosta P; Scielzo C; Vallario A; Camporeale A; Granziero L; Caligaris-Cappio F
Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia
2022-01-01 Houshmand, Mohammad; Vitale, Nicoletta; Orso, Francesca; Cignetti, Alessandro; Molineris, Ivan; Gaidano, Valentina; Sainas, Stefano; Giorgis, Marta; Boschi, Donatella; Fava, Carmen; Passoni, Alice; Gai, Marta; Geuna, Massimo; Sora, Federica; Iurlo, Alessandra; Abruzzese, Elisabetta; Breccia, Massimo; Mulas, Olga; Caocci, Giovanni; Castagnetti, Fausto; Taverna, Daniela; Oliviero, Salvatore; Pane, Fabrizio; Lolli, Marco Lucio; Circosta, Paola; Saglio, Giuseppe
Discovery of novel and potent human Dihydroorotate Dehydrogenase inhibitor that induces differentiation and apoptosis in Acute Myeloid Leukaemia
2024-01-01 Villella Noemi, Sainas Stefano, Circosta Paola, Caliandro Ileana, Fornaseri Federico, Alberti Marta, Miggiano Riccardo, Giorgis Marta, Vázquez Santiago, Boschi Donatella, Lolli Marco Lucio
Discovery of novel and potent human Dihydroorotate Dehydrogenase inhibitor that induces differentiation and apoptosis in Acute Myeloid Leukaemia
2024-01-01 Villella Noemi, Sainas Stefano, Circosta Paola, Caliandro Ileana, Fornaseri Federico, Alberti Marta, Miggiano Riccardo, Giorgis Marta, Vázquez Santiago, Boschi Donatella, Lolli Marco Lucio
Discovery of novel and potent human Dihydroorotate Dehydrogenase inhibitor that induces differentiation and apoptosis in Acute Myeloid Leukaemia
2024-01-01 Villella Noemi, Sainas Stefano, Circosta Paola, Caliandro Ileana, Fornaseri Federico, Alberti Marta, Miggiano Riccardo, Giorgis Marta, Vázquez Santiago, Boschi Donatella, Lolli Marco Lucio
Emerging therapies for acute myeloid leukaemia using hDHODH inhibitors
2019-01-01 Sainas Stefano, Pippione Agnese Chiara, Bonanni Davide, Giorgis Marta, Lupino Elisa, Circosta Paola, Gaidano Valentina, Cignetti Alessandro, Piccinini Marco, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lucio
Emerging therapies for acute myeloid leukaemia using hDHODH inhibitors able to restore in vitro and in vivo myeloid differentiation
2019-01-01 Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Marilena Marraudino, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli
Enhancement of the metabolic stability in 2-hydroxypyrazolo[1,5-a]pyridine scaffold-based inhibitors of human dihydroorotate dehydrogenase (hDHODH)
2024-01-01 Chiara Vigato, Stefano Sainas, Marta Giorgis, Agnese C. Pippione, Alice Passoni, Renzo Bagnati, Paola Circosta, Riccardo Miggiano, Marta Alberti , Donatella Boschi, and Marco L. Lolli
Full chimaeric CAR.CIK from patients engrafted after allogeneic haematopoietic cell transplant: Feasibility, anti-leukaemic potential and alloreactivity across major human leukocyte antigen barriers
2023-01-01 Circosta, Paola; Donini, Chiara; Gallo, Susanna; Giraudo, Lidia; Gammaitoni, Loretta; Rotolo, Ramona; Galvagno, Federica; Capellero, Sonia; Basiricò, Marco; Casucci, Monica; Aglietta, Massimo; Ferrero, Ivana; Fagioli, Franca; Cignetti, Alessandro; Carnevale-Schianca, Fabrizio; Leuci, Valeria; Sangiolo, Dario
Functional phenotype of peripheral lymphocytes in Churg Strauss syndrome
2012-01-01 Boita, M; Guida, G; Circosta, P; Heffler, E; Stella, S; Elia, A; Geuna, M; Rolla, G; Cignetti, A
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| A differentiating and apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor | 2021 | Stefano Sainas, Paola Circosta, Marta Giorgis, Agnese Chiara Pippione, Marilena Marraudino, Mohammad Houshmand, Brigitta Bonaldo, Valentina Gaidano, Alessandro Cignetti, Stefano Gotti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli | |
| A differentiating and apoptotic therapy for acute myeloid leukaemia using potent human dihydroorotate dehydrogenase inhibitors. | 2019 | Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Marilena Marraudino, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli | |
| A new pro-apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor | 2021 | Sainas Sainas, Paola Circosta, Noemi Villella, Elena Martino, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Caterina Peraldo Neia, Giovanna Chiorino, Salam Al-Karadaghi, Donatella Boschi, Giuseppe Saglio, Marco Lucio Lolli. | |
| Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity | 2006 | PETRELLI A; CIRCOSTA P; GRANZIERO L; MAZZONE M; PISACANE A; FENOGLIO S; COMOGLIO P; GIORDANO S | |
| Apoptotic and differentiating therapy for AML using potent human dihydroorotate dehydrogenase inhibitor | 2021 | Sainas Sainas, Circosta Paola, Pippione Agnese Chiara, Giorgis Marta, Marraudino Marilena, Houshmand Mohammad, Bonaldo Brigitta, Gaidano Valentina, Cignetti Alessandro, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lolli | |
| CD100/Plexin-B1 interactions sustain proliferation and survival of normal and Leukemic CD5+ B lymphocytes | 2003 | GRNAZIERO L; CIRCOSTA P; SCIELZO C; FRISALDI E; STELLA S; GEUNA M; S. GIORDANO; GHIA P; CALIGARIS CAPPIO F | |
| Clonal CD8+ TCR-Vbeta expanded populations with effector memory phenotype in Churg Strauss syndrome | 2008 | Giuseppe Guida; Antonella Vallario; Stefania Stella; Monica Boita; Paola Circosta; Sara Mariani; Giuseppina Prato; Enrico Heffler; Roberta Bergia; Antonino Sottile; Giovanni Rolla; Alessandro Cignetti | |
| Cytokine-induced killer cells engineered with exogenous t-cell receptors directed against melanoma antigens: Enhanced efficacy of effector cells endowed with a double mechanism of tumor recognition | 2015 | Elia, Angela R; Circosta, Paola; Sangiolo, Dario; Bonini, Chiara; Gammaitoni, Loretta; Mastaglio, Sara; Genovese, Pietro; Geuna, Massimo; Avolio, Fabio; Inghirami, Giorgio; Tarella, Corrado; Cignetti, Alessandro | |
| Development of Potent Human Dihydroorotate Dehydrogenase Inhibitors Able to Induces Myeloid Differentiation | 2018 | Stefano Sainas, Agnese C. Pippione, Davide Bonanni, Marta Giorgis, Elisa Lupino, Enrico Giraudo, Paola Circosta, Valentina Gaidano, Alessandro Cignetti, Marco Piccinini, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco L. Lolli | |
| DHODH inhibitors and leukemia: an emergent interest for new myeloid differentiation agents | 2018 | Sainas, S; Pippione, AC; Boschi, D; Gaidano, V; Circosta, P; Cignetti, A; Dosio, F; Lolli, ML | |
| Differential effects on CLL cell survival exerted by different microenvironmental elements. | 2005 | Ghia P; Circosta P; Scielzo C; Vallario A; Camporeale A; Granziero L; Caligaris-Cappio F | |
| Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia | 2022 | Houshmand, Mohammad; Vitale, Nicoletta; Orso, Francesca; Cignetti, Alessandro; Molineris, Ivan; Gaidano, Valentina; Sainas, Stefano; Giorgis, Marta; Boschi, Donatella; Fava, Carmen; Passoni, Alice; Gai, Marta; Geuna, Massimo; Sora, Federica; Iurlo, Alessandra; Abruzzese, Elisabetta; Breccia, Massimo; Mulas, Olga; Caocci, Giovanni; Castagnetti, Fausto; Taverna, Daniela; Oliviero, Salvatore; Pane, Fabrizio; Lolli, Marco Lucio; Circosta, Paola; Saglio, Giuseppe | |
| Discovery of novel and potent human Dihydroorotate Dehydrogenase inhibitor that induces differentiation and apoptosis in Acute Myeloid Leukaemia | 2024 | Villella Noemi, Sainas Stefano, Circosta Paola, Caliandro Ileana, Fornaseri Federico, Alberti Marta, Miggiano Riccardo, Giorgis Marta, Vázquez Santiago, Boschi Donatella, Lolli Marco Lucio | |
| Discovery of novel and potent human Dihydroorotate Dehydrogenase inhibitor that induces differentiation and apoptosis in Acute Myeloid Leukaemia | 2024 | Villella Noemi, Sainas Stefano, Circosta Paola, Caliandro Ileana, Fornaseri Federico, Alberti Marta, Miggiano Riccardo, Giorgis Marta, Vázquez Santiago, Boschi Donatella, Lolli Marco Lucio | |
| Discovery of novel and potent human Dihydroorotate Dehydrogenase inhibitor that induces differentiation and apoptosis in Acute Myeloid Leukaemia | 2024 | Villella Noemi, Sainas Stefano, Circosta Paola, Caliandro Ileana, Fornaseri Federico, Alberti Marta, Miggiano Riccardo, Giorgis Marta, Vázquez Santiago, Boschi Donatella, Lolli Marco Lucio | |
| Emerging therapies for acute myeloid leukaemia using hDHODH inhibitors | 2019 | Sainas Stefano, Pippione Agnese Chiara, Bonanni Davide, Giorgis Marta, Lupino Elisa, Circosta Paola, Gaidano Valentina, Cignetti Alessandro, Piccinini Marco, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lucio | |
| Emerging therapies for acute myeloid leukaemia using hDHODH inhibitors able to restore in vitro and in vivo myeloid differentiation | 2019 | Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Marilena Marraudino, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli | |
| Enhancement of the metabolic stability in 2-hydroxypyrazolo[1,5-a]pyridine scaffold-based inhibitors of human dihydroorotate dehydrogenase (hDHODH) | 2024 | Chiara Vigato, Stefano Sainas, Marta Giorgis, Agnese C. Pippione, Alice Passoni, Renzo Bagnati, Paola Circosta, Riccardo Miggiano, Marta Alberti , Donatella Boschi, and Marco L. Lolli | |
| Full chimaeric CAR.CIK from patients engrafted after allogeneic haematopoietic cell transplant: Feasibility, anti-leukaemic potential and alloreactivity across major human leukocyte antigen barriers | 2023 | Circosta, Paola; Donini, Chiara; Gallo, Susanna; Giraudo, Lidia; Gammaitoni, Loretta; Rotolo, Ramona; Galvagno, Federica; Capellero, Sonia; Basiricò, Marco; Casucci, Monica; Aglietta, Massimo; Ferrero, Ivana; Fagioli, Franca; Cignetti, Alessandro; Carnevale-Schianca, Fabrizio; Leuci, Valeria; Sangiolo, Dario | |
| Functional phenotype of peripheral lymphocytes in Churg Strauss syndrome | 2012 | Boita, M; Guida, G; Circosta, P; Heffler, E; Stella, S; Elia, A; Geuna, M; Rolla, G; Cignetti, A |