HOUSHMAND, MOHAMMAD
HOUSHMAND, MOHAMMAD
SCIENZE CLINICHE E BIOLOGICHE
A differentiating and apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor
2021-01-01 Stefano Sainas, Paola Circosta, Marta Giorgis, Agnese Chiara Pippione, Marilena Marraudino, Mohammad Houshmand, Brigitta Bonaldo, Valentina Gaidano, Alessandro Cignetti, Stefano Gotti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli
A new pro-apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor
2021-01-01 Sainas Sainas, Paola Circosta, Noemi Villella, Elena Martino, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Caterina Peraldo Neia, Giovanna Chiorino, Salam Al-Karadaghi, Donatella Boschi, Giuseppe Saglio, Marco Lucio Lolli.
Apoptotic and differentiating therapy for AML using potent human dihydroorotate dehydrogenase inhibitor
2021-01-01 Sainas Sainas, Circosta Paola, Pippione Agnese Chiara, Giorgis Marta, Marraudino Marilena, Houshmand Mohammad, Bonaldo Brigitta, Gaidano Valentina, Cignetti Alessandro, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lolli
Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia
2021-11-21
Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia
2022-01-01 Houshmand, Mohammad; Vitale, Nicoletta; Orso, Francesca; Cignetti, Alessandro; Molineris, Ivan; Gaidano, Valentina; Sainas, Stefano; Giorgis, Marta; Boschi, Donatella; Fava, Carmen; Passoni, Alice; Gai, Marta; Geuna, Massimo; Sora, Federica; Iurlo, Alessandra; Abruzzese, Elisabetta; Breccia, Massimo; Mulas, Olga; Caocci, Giovanni; Castagnetti, Fausto; Taverna, Daniela; Oliviero, Salvatore; Pane, Fabrizio; Lolli, Marco Lucio; Circosta, Paola; Saglio, Giuseppe
Hydroxylated heterocycles as a bioisosteric tool to Modulate the carboxylic function into design potent human Dihydroorotate Dehydrogenase inhibitors
2021-01-01 Stefano Sainas, Paola Circosta, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli
Meds433, a New Dihydroorotate Dehydrogenase Inhibitor, Induces Apoptosis and Differentiation in Acute Myeloid Leukemia
2019-01-01 Gaidano, Valentina; Circosta, Paola; Cignetti, Alessandro; Houshmand, Mohammad; Vitale, Nicoletta; Sainas, Stefano; Pippione, Agnese; Marraudino, Marilena; Bonaldo, Brigitta; Giorgis, Marta; Boschi, Donatella; Lolli, Marco Lucio; Saglio, Giuseppe
Nanocarriers as magic bullets in the treatment of leukemia
2020-01-01 Houshmand M.; Garello F.; Circosta P.; Stefania R.; Aime S.; Saglio G.; Giachino C.
Shedding Light on Targeting Chronic Myeloid Leukemia Stem Cells
2021-01-01 Houshmand, Mohammad; Kazemi, Alireza; Anjam Najmedini, Ali; Ali, Muhammad Shahzad; Gaidano, Valentina; Cignetti, Alessandro; Fava, Carmen; Cilloni, Daniela; Saglio, Giuseppe; Circosta, Paola
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold: SAR of the Biphenyl Moiety
2021-01-01 Sainas S.; Giorgis M.; Circosta P.; Gaidano V.; Bonanni D.; Pippione A.C.; Bagnati R.; Passoni A.; Qiu Y.; Cojocaru C.F.; Canepa B.; Bona A.; Rolando B.; Mishina M.; Ramondetti C.; Buccinna B.; Piccinini M.; Houshmand M.; Cignetti A.; Giraudo E.; Al-Karadaghi S.; Boschi D.; Saglio G.; Lolli M.L.
Targeting chronic myeloid leukemia stem/progenitor cells using venetoclax-loaded immunoliposome
2021-01-01 Houshmand M.; Garello F.; Stefania R.; Gaidano V.; Cignetti A.; Spinelli M.; Fava C.; Zarif M.N.; Galimberti S.; Pungolino E.; Annunziata M.; Luciano L.; Specchia G.; Bocchia M.; Binotto G.; Bonifacio M.; Martino B.; Pregno P.; Stagno F.; Iurlo A.; Russo S.; Aime S.; Circosta P.; Saglio G.
The inhibition of human DHODH by M433 leads to differentiation and apoptosis in acute myeloid leukemia
2021-01-01 Sainas Stefano, Circosta Paola, Pippione Agnese Chiara, Giorgis Marta, Marraudino Marilena, Houshmand Mohammad, Bonaldo Brigitta, Gaidano Valentina, Cignetti Alessandro, Gotti Stefano, Saglio Giuseppe., Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lucio
The synergism between DHODH inhibitors and dipyridamole leads to metabolic lethality in acute myeloid leukemia
2021-01-01 Gaidano V.; Houshmand M.; Vitale N.; Carra G.; Morotti A.; Tenace V.; Rapelli S.; Sainas S.; Pippione A.C.; Giorgis M.; Boschi D.; Lolli M.L.; Cilloni D.; Cignetti A.; Saglio G.; Circosta P.
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| A differentiating and apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor | 2021 | Stefano Sainas, Paola Circosta, Marta Giorgis, Agnese Chiara Pippione, Marilena Marraudino, Mohammad Houshmand, Brigitta Bonaldo, Valentina Gaidano, Alessandro Cignetti, Stefano Gotti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli | |
| A new pro-apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor | 2021 | Sainas Sainas, Paola Circosta, Noemi Villella, Elena Martino, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Caterina Peraldo Neia, Giovanna Chiorino, Salam Al-Karadaghi, Donatella Boschi, Giuseppe Saglio, Marco Lucio Lolli. | |
| Apoptotic and differentiating therapy for AML using potent human dihydroorotate dehydrogenase inhibitor | 2021 | Sainas Sainas, Circosta Paola, Pippione Agnese Chiara, Giorgis Marta, Marraudino Marilena, Houshmand Mohammad, Bonaldo Brigitta, Gaidano Valentina, Cignetti Alessandro, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lolli | |
| Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia | 2021 | - | |
| Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia | 2022 | Houshmand, Mohammad; Vitale, Nicoletta; Orso, Francesca; Cignetti, Alessandro; Molineris, Ivan; Gaidano, Valentina; Sainas, Stefano; Giorgis, Marta; Boschi, Donatella; Fava, Carmen; Passoni, Alice; Gai, Marta; Geuna, Massimo; Sora, Federica; Iurlo, Alessandra; Abruzzese, Elisabetta; Breccia, Massimo; Mulas, Olga; Caocci, Giovanni; Castagnetti, Fausto; Taverna, Daniela; Oliviero, Salvatore; Pane, Fabrizio; Lolli, Marco Lucio; Circosta, Paola; Saglio, Giuseppe | |
| Hydroxylated heterocycles as a bioisosteric tool to Modulate the carboxylic function into design potent human Dihydroorotate Dehydrogenase inhibitors | 2021 | Stefano Sainas, Paola Circosta, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli | |
| Meds433, a New Dihydroorotate Dehydrogenase Inhibitor, Induces Apoptosis and Differentiation in Acute Myeloid Leukemia | 2019 | Gaidano, Valentina; Circosta, Paola; Cignetti, Alessandro; Houshmand, Mohammad; Vitale, Nicoletta; Sainas, Stefano; Pippione, Agnese; Marraudino, Marilena; Bonaldo, Brigitta; Giorgis, Marta; Boschi, Donatella; Lolli, Marco Lucio; Saglio, Giuseppe | |
| Nanocarriers as magic bullets in the treatment of leukemia | 2020 | Houshmand M.; Garello F.; Circosta P.; Stefania R.; Aime S.; Saglio G.; Giachino C. | |
| Shedding Light on Targeting Chronic Myeloid Leukemia Stem Cells | 2021 | Houshmand, Mohammad; Kazemi, Alireza; Anjam Najmedini, Ali; Ali, Muhammad Shahzad; Gaidano, Valentina; Cignetti, Alessandro; Fava, Carmen; Cilloni, Daniela; Saglio, Giuseppe; Circosta, Paola | |
| Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold: SAR of the Biphenyl Moiety | 2021 | Sainas S.; Giorgis M.; Circosta P.; Gaidano V.; Bonanni D.; Pippione A.C.; Bagnati R.; Passoni A.; Qiu Y.; Cojocaru C.F.; Canepa B.; Bona A.; Rolando B.; Mishina M.; Ramondetti C.; Buccinna B.; Piccinini M.; Houshmand M.; Cignetti A.; Giraudo E.; Al-Karadaghi S.; Boschi D.; Saglio G.; Lolli M.L. | |
| Targeting chronic myeloid leukemia stem/progenitor cells using venetoclax-loaded immunoliposome | 2021 | Houshmand M.; Garello F.; Stefania R.; Gaidano V.; Cignetti A.; Spinelli M.; Fava C.; Zarif M.N.; Galimberti S.; Pungolino E.; Annunziata M.; Luciano L.; Specchia G.; Bocchia M.; Binotto G.; Bonifacio M.; Martino B.; Pregno P.; Stagno F.; Iurlo A.; Russo S.; Aime S.; Circosta P.; Saglio G. | |
| The inhibition of human DHODH by M433 leads to differentiation and apoptosis in acute myeloid leukemia | 2021 | Sainas Stefano, Circosta Paola, Pippione Agnese Chiara, Giorgis Marta, Marraudino Marilena, Houshmand Mohammad, Bonaldo Brigitta, Gaidano Valentina, Cignetti Alessandro, Gotti Stefano, Saglio Giuseppe., Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lucio | |
| The synergism between DHODH inhibitors and dipyridamole leads to metabolic lethality in acute myeloid leukemia | 2021 | Gaidano V.; Houshmand M.; Vitale N.; Carra G.; Morotti A.; Tenace V.; Rapelli S.; Sainas S.; Pippione A.C.; Giorgis M.; Boschi D.; Lolli M.L.; Cilloni D.; Cignetti A.; Saglio G.; Circosta P. |