VILLELLA, NOEMI
VILLELLA, NOEMI
SCIENZA E TECNOLOGIA DEL FARMACO
A new pro-apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor
2021-01-01 Sainas Sainas, Paola Circosta, Noemi Villella, Elena Martino, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Caterina Peraldo Neia, Giovanna Chiorino, Salam Al-Karadaghi, Donatella Boschi, Giuseppe Saglio, Marco Lucio Lolli.
Design of new human Dihydroorotate Dehydrogenase inhibitors: amide bioisosterism in MEDS433 optimization
2021-01-01 Martino Elena, Villella Noemi, Vigato Chiara, Cerrina Matteo, Bersani Matteo, Giorgis Marta, Sainas Stefano, Boschi Donatella, Lolli Marco Lucio
Design, synthesis and co-crystallization of new Plasmodium falciparum dihydroorotate dehydrogenase inhibitors based on hydroxypyrazole scaffold
2019-01-01 Noemi Villella, Agnese Chiara Pippione, Stefano Sainas, Donatella Boschi, Rosmarie Friemann, Alberto Gimenéz, Efrain Salamanca, Marco Lucio Lolli
Design, synthesis and co-crystallization of new Plasmodium falciparum dihydroorotate dehydrogenase inhibitors based on hydroxypyrazole scaffold
2019-01-01 Noemi Villella, Agnese Chiara Pippione, Stefano Sainas, Donatella Boschi, Rosmarie Friemann, Alberto Gimenéz, Efrain Salamanca, Marco Lucio Lolli
Discovery of novel and potent human Dihydroorotate Dehydrogenase inhibitor that induces differentiation and apoptosis in Acute Myeloid Leukaemia
2024-01-01 Villella Noemi, Sainas Stefano, Circosta Paola, Caliandro Ileana, Fornaseri Federico, Alberti Marta, Miggiano Riccardo, Giorgis Marta, Vázquez Santiago, Boschi Donatella, Lolli Marco Lucio
Discovery of novel and potent human Dihydroorotate Dehydrogenase inhibitor that induces differentiation and apoptosis in Acute Myeloid Leukaemia
2024-01-01 Villella Noemi, Sainas Stefano, Circosta Paola, Caliandro Ileana, Fornaseri Federico, Alberti Marta, Miggiano Riccardo, Giorgis Marta, Vázquez Santiago, Boschi Donatella, Lolli Marco Lucio
Discovery of novel and potent human Dihydroorotate Dehydrogenase inhibitor that induces differentiation and apoptosis in Acute Myeloid Leukaemia
2024-01-01 Villella Noemi, Sainas Stefano, Circosta Paola, Caliandro Ileana, Fornaseri Federico, Alberti Marta, Miggiano Riccardo, Giorgis Marta, Vázquez Santiago, Boschi Donatella, Lolli Marco Lucio
Identification of a potent and innovative inhibitor of human Dihydroorotate Dehydrogenase, triggering differentiation and apoptosis in Acute Myeloid Leukaemia
2024-01-01 Villella Noemi, Sainas Stefano, Circosta Paola, Caliandro Ileana, Fornaseri Federico, Alberti Marta, Miggiano Riccardo, Giorgis Marta, Vázquez Santiago, Boschi Donatella, Lolli Marco Lucio
Identification of a potent and innovative inhibitor of human Dihydroorotate Dehydrogenase, triggering differentiation and apoptosis in Acute Myeloid Leukaemia
2024-01-01 Villella Noemi, Sainas Stefano, Circosta Paola, Caliandro Ileana, Fornaseri Federico, Alberti Marta, Miggiano Riccardo, Giorgis Marta, Vázquez Santiago, Boschi Donatella, Lolli Marco Lucio
Improving the fluorescent profile of pyrazolo [1,5-a]pyridine fluorophores for developing new fluorescent probes
2022-01-01 Elena Martino, Noemi Villella, Stefano Sainas, Francesco Bavo, Claudio Garino, Simona Mattiussi, Agnese Chiara Pippione, Marta Giorgis, Donatella Boschi, Bente Frølund, Marco Lucio Lolli.
Inhibition of the activity of the transmembrane form of chloride intracellular channel 1 (tmclic1): a novel pharmacological tool in multiple targeted therapy for glioblastoma treatment.
2021-01-01 Boschi Donatella., Pippione Agnese Chiara, Villella Noemi, Lolli Marco Lucio, Vitale Rosa Maria, Mazzanti Michele, Pattarozzi Alessandra, Barbieri Federica, Florio Tullio
New hydroxypyrazole inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase: physical-chemical characterization and biological evaluation
2024-01-01 Fornaseri Federico, Giorgis Marta, Pippione Agnese Chiara, Caliandro Ileana, Villella Noemi, Alberti Marta, Miggiano Riccardo, Salamanca Efrain, Gimenez Aberto, Sharma Manmohan, Lolli Marco Lucio, Boschi Donatella
Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with hydroxypyrazole core: new scaffolds against malaria disease
2019-01-01 Pippione AC, Sainas S, Giraudo A, Bonanni D, Villella N, Bertea C, Friemann R, Al-Karadaghi S, Boschi D, Lolli ML.
Targeting dihydroorotate dehydrogenase (DHODH) in anti-infective research: focusing in the design of on anti-malarial and anti-tuberculosis agents
2021-01-01 Marco Lucio Lolli, Agnese Chiara Pippione, Riccardo Miggiano, Davide Ferraris, Marta Giorgis, Marta Alberti, Noemi Villella, Stefano Sainas, Salam Al-Karadaghi, Donatella Boschi
Targeting Plasmodium falciparum dihydroorotate dehydrogenase: design, synthesis, co-crystallization and biological evaluation of new 3-hydroxypyrazole scaffold-based inhibitors
2022-01-01 Noemi Villella, Agnese Chiara Pippione, Stefano Sainas, Marta Giorgis, Giulio Poli, Tiziano Tuccinardi, Marta Alberti, Riccardo Miggiano, Davide Maria Ferraris, Luca Marchisio, Sandrine Cojean, Efrain Salamanca, Alberto Jose Gimenez, Barbara Buccinnà, Cristina Ramondetti, Marco Piccinini, Marco Lucio Lolli, Donatella Boschi
Targeting Plasmodium falciparum dihydroorotate dehydrogenase: design, synthesis, co-crystallization and biological evaluation of new 3-hydroxypyrazole scaffold-based inhibitors
2022-01-01 Noemi Villella, Agnese Chiara Pippione, Stefano Sainas, Marta Giorgis, Giulio Poli, Tiziano Tuccinardi, Marta Alberti, Riccardo Miggiano, Davide Maria Ferraris, Luca Marchisio, Sandrine Cojean, Alberto Gimenéz, Efrain Salamanca, Barbara Buccinnà, Cristina Ramondetti, Marco Piccinini, Marco Lucio Lolli, Donatella Boschi.
Targeting the human Dihydroorotate Dehydrogenase (hDHODH) by a Scaffold Hopping Bioisosteric approach using Hydroxylated Pentatomic Heterocycles
2016-01-01 Sainas Stefano; Pippione Agnese Chiara; Carnovale Irene Maria; Giraudo Alessandro; Giorgis Marta; de Campos Braga Rodolpho; Andrade Carolina H; Villella Noemi; Friemann Rosmarie; Piccinini Marco; Lupino Elisa; Al-karadaghi Salam; Boschi Donatella;Lolli Marco Lucio
Targeting the human Dihydroorotate Dehydrogenase (hDHODH) by a Scaffold Hopping Bioisosteric approach using Hydroxylated Pentatomic Heterocycles
2016-01-01 Stefano Sainas, Agnese Chiara Pippione, Irene Maria Carnovale, Alessandro Giraudo, Marta Giorgis, Rodolpho B. Braga, Carolina H. Andrade, Noemi Villella, Marco Piccinini, Elisa Lupino, Rosmarie Friemann, Salam Al-Kadaraghi, Donatella Boschi, Marco L. Lolli
The therapeutic potential of PIN-1 inhibition: new agents and strategic approaches
2024-01-01 Vetrò Tommaso, Villella Noemi, Sainas Stefano, Giorgis Marta, Boschi Donatella, Bertolio Rebecca, Rustighi Alessandra, Amodeo Piero, Vitale Rosa Maria, Del Sal Giannino, Lolli Marco Lucio, Pippione Agnese Chiara
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| A new pro-apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor | 2021 | Sainas Sainas, Paola Circosta, Noemi Villella, Elena Martino, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Caterina Peraldo Neia, Giovanna Chiorino, Salam Al-Karadaghi, Donatella Boschi, Giuseppe Saglio, Marco Lucio Lolli. | |
| Design of new human Dihydroorotate Dehydrogenase inhibitors: amide bioisosterism in MEDS433 optimization | 2021 | Martino Elena, Villella Noemi, Vigato Chiara, Cerrina Matteo, Bersani Matteo, Giorgis Marta, Sainas Stefano, Boschi Donatella, Lolli Marco Lucio | |
| Design, synthesis and co-crystallization of new Plasmodium falciparum dihydroorotate dehydrogenase inhibitors based on hydroxypyrazole scaffold | 2019 | Noemi Villella, Agnese Chiara Pippione, Stefano Sainas, Donatella Boschi, Rosmarie Friemann, Alberto Gimenéz, Efrain Salamanca, Marco Lucio Lolli | |
| Design, synthesis and co-crystallization of new Plasmodium falciparum dihydroorotate dehydrogenase inhibitors based on hydroxypyrazole scaffold | 2019 | Noemi Villella, Agnese Chiara Pippione, Stefano Sainas, Donatella Boschi, Rosmarie Friemann, Alberto Gimenéz, Efrain Salamanca, Marco Lucio Lolli | |
| Discovery of novel and potent human Dihydroorotate Dehydrogenase inhibitor that induces differentiation and apoptosis in Acute Myeloid Leukaemia | 2024 | Villella Noemi, Sainas Stefano, Circosta Paola, Caliandro Ileana, Fornaseri Federico, Alberti Marta, Miggiano Riccardo, Giorgis Marta, Vázquez Santiago, Boschi Donatella, Lolli Marco Lucio | |
| Discovery of novel and potent human Dihydroorotate Dehydrogenase inhibitor that induces differentiation and apoptosis in Acute Myeloid Leukaemia | 2024 | Villella Noemi, Sainas Stefano, Circosta Paola, Caliandro Ileana, Fornaseri Federico, Alberti Marta, Miggiano Riccardo, Giorgis Marta, Vázquez Santiago, Boschi Donatella, Lolli Marco Lucio | |
| Discovery of novel and potent human Dihydroorotate Dehydrogenase inhibitor that induces differentiation and apoptosis in Acute Myeloid Leukaemia | 2024 | Villella Noemi, Sainas Stefano, Circosta Paola, Caliandro Ileana, Fornaseri Federico, Alberti Marta, Miggiano Riccardo, Giorgis Marta, Vázquez Santiago, Boschi Donatella, Lolli Marco Lucio | |
| Identification of a potent and innovative inhibitor of human Dihydroorotate Dehydrogenase, triggering differentiation and apoptosis in Acute Myeloid Leukaemia | 2024 | Villella Noemi, Sainas Stefano, Circosta Paola, Caliandro Ileana, Fornaseri Federico, Alberti Marta, Miggiano Riccardo, Giorgis Marta, Vázquez Santiago, Boschi Donatella, Lolli Marco Lucio | |
| Identification of a potent and innovative inhibitor of human Dihydroorotate Dehydrogenase, triggering differentiation and apoptosis in Acute Myeloid Leukaemia | 2024 | Villella Noemi, Sainas Stefano, Circosta Paola, Caliandro Ileana, Fornaseri Federico, Alberti Marta, Miggiano Riccardo, Giorgis Marta, Vázquez Santiago, Boschi Donatella, Lolli Marco Lucio | |
| Improving the fluorescent profile of pyrazolo [1,5-a]pyridine fluorophores for developing new fluorescent probes | 2022 | Elena Martino, Noemi Villella, Stefano Sainas, Francesco Bavo, Claudio Garino, Simona Mattiussi, Agnese Chiara Pippione, Marta Giorgis, Donatella Boschi, Bente Frølund, Marco Lucio Lolli. | |
| Inhibition of the activity of the transmembrane form of chloride intracellular channel 1 (tmclic1): a novel pharmacological tool in multiple targeted therapy for glioblastoma treatment. | 2021 | Boschi Donatella., Pippione Agnese Chiara, Villella Noemi, Lolli Marco Lucio, Vitale Rosa Maria, Mazzanti Michele, Pattarozzi Alessandra, Barbieri Federica, Florio Tullio | |
| New hydroxypyrazole inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase: physical-chemical characterization and biological evaluation | 2024 | Fornaseri Federico, Giorgis Marta, Pippione Agnese Chiara, Caliandro Ileana, Villella Noemi, Alberti Marta, Miggiano Riccardo, Salamanca Efrain, Gimenez Aberto, Sharma Manmohan, Lolli Marco Lucio, Boschi Donatella | |
| Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with hydroxypyrazole core: new scaffolds against malaria disease | 2019 | Pippione AC, Sainas S, Giraudo A, Bonanni D, Villella N, Bertea C, Friemann R, Al-Karadaghi S, Boschi D, Lolli ML. | |
| Targeting dihydroorotate dehydrogenase (DHODH) in anti-infective research: focusing in the design of on anti-malarial and anti-tuberculosis agents | 2021 | Marco Lucio Lolli, Agnese Chiara Pippione, Riccardo Miggiano, Davide Ferraris, Marta Giorgis, Marta Alberti, Noemi Villella, Stefano Sainas, Salam Al-Karadaghi, Donatella Boschi | |
| Targeting Plasmodium falciparum dihydroorotate dehydrogenase: design, synthesis, co-crystallization and biological evaluation of new 3-hydroxypyrazole scaffold-based inhibitors | 2022 | Noemi Villella, Agnese Chiara Pippione, Stefano Sainas, Marta Giorgis, Giulio Poli, Tiziano Tuccinardi, Marta Alberti, Riccardo Miggiano, Davide Maria Ferraris, Luca Marchisio, Sandrine Cojean, Efrain Salamanca, Alberto Jose Gimenez, Barbara Buccinnà, Cristina Ramondetti, Marco Piccinini, Marco Lucio Lolli, Donatella Boschi | |
| Targeting Plasmodium falciparum dihydroorotate dehydrogenase: design, synthesis, co-crystallization and biological evaluation of new 3-hydroxypyrazole scaffold-based inhibitors | 2022 | Noemi Villella, Agnese Chiara Pippione, Stefano Sainas, Marta Giorgis, Giulio Poli, Tiziano Tuccinardi, Marta Alberti, Riccardo Miggiano, Davide Maria Ferraris, Luca Marchisio, Sandrine Cojean, Alberto Gimenéz, Efrain Salamanca, Barbara Buccinnà, Cristina Ramondetti, Marco Piccinini, Marco Lucio Lolli, Donatella Boschi. | |
| Targeting the human Dihydroorotate Dehydrogenase (hDHODH) by a Scaffold Hopping Bioisosteric approach using Hydroxylated Pentatomic Heterocycles | 2016 | Sainas Stefano; Pippione Agnese Chiara; Carnovale Irene Maria; Giraudo Alessandro; Giorgis Marta; de Campos Braga Rodolpho; Andrade Carolina H; Villella Noemi; Friemann Rosmarie; Piccinini Marco; Lupino Elisa; Al-karadaghi Salam; Boschi Donatella;Lolli Marco Lucio | |
| Targeting the human Dihydroorotate Dehydrogenase (hDHODH) by a Scaffold Hopping Bioisosteric approach using Hydroxylated Pentatomic Heterocycles | 2016 | Stefano Sainas, Agnese Chiara Pippione, Irene Maria Carnovale, Alessandro Giraudo, Marta Giorgis, Rodolpho B. Braga, Carolina H. Andrade, Noemi Villella, Marco Piccinini, Elisa Lupino, Rosmarie Friemann, Salam Al-Kadaraghi, Donatella Boschi, Marco L. Lolli | |
| The therapeutic potential of PIN-1 inhibition: new agents and strategic approaches | 2024 | Vetrò Tommaso, Villella Noemi, Sainas Stefano, Giorgis Marta, Boschi Donatella, Bertolio Rebecca, Rustighi Alessandra, Amodeo Piero, Vitale Rosa Maria, Del Sal Giannino, Lolli Marco Lucio, Pippione Agnese Chiara |