CINECA IRIS Institutional Research Information System

DE SIMONE, Angela
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 1.390
AS - Asia 580
EU - Europa 472
SA - Sud America 19
AF - Africa 3
OC - Oceania 2
Totale 2.466
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 1.378
CN - Cina 222
SG - Singapore 192
IE - Irlanda 175
IT - Italia 148
IN - India 50
HK - Hong Kong 29
DE - Germania 28
VN - Vietnam 23
SE - Svezia 20
IR - Iran 18
GB - Regno Unito 14
BR - Brasile 12
ES - Italia 12
FR - Francia 12
GR - Grecia 12
ID - Indonesia 10
KR - Corea 9
NL - Olanda 9
FI - Finlandia 6
TR - Turchia 6
BD - Bangladesh 5
CA - Canada 5
HU - Ungheria 5
AT - Austria 4
CZ - Repubblica Ceca 4
IQ - Iraq 4
MX - Messico 4
PL - Polonia 4
TW - Taiwan 4
UA - Ucraina 4
CL - Cile 3
DK - Danimarca 3
GT - Guatemala 3
MO - Macao, regione amministrativa speciale della Cina 3
RU - Federazione Russa 3
AU - Australia 2
CH - Svizzera 2
JP - Giappone 2
NG - Nigeria 2
NO - Norvegia 2
PK - Pakistan 2
VE - Venezuela 2
AD - Andorra 1
AM - Armenia 1
BG - Bulgaria 1
CI - Costa d'Avorio 1
CO - Colombia 1
EC - Ecuador 1
RO - Romania 1
RS - Serbia 1
SK - Slovacchia (Repubblica Slovacca) 1
Totale 2.466
Salva come PNG Salva come JPEG
Città #
Santa Clara 387
Chandler 277
Dublin 174
Singapore 96
Medford 74
Beijing 69
Princeton 54
Columbus 53
Wilmington 36
Torino 34
Ashburn 26
Fairfield 23
Turin 23
Hong Kong 20
Dong Ket 17
Redwood City 16
Bologna 15
Cambridge 15
Hangzhou 15
Shanghai 15
Boston 10
Chengdu 10
Central District 9
Jakarta 9
Nuremberg 9
Houston 8
Milan 8
Seattle 8
Tehran 8
Chennai 7
Hefei 7
Hyderabad 7
Norwalk 7
Nyköping 7
Woodbridge 7
Ann Arbor 6
Kunming 6
London 6
Xian 6
Barcelona 5
Dhaka 5
Helsinki 5
Nanjing 5
Pune 5
Szeged 5
Basrah 4
Leinì 4
Los Angeles 4
Salvador 4
San Diego 4
Seoul 4
Toronto 4
Amroha 3
Fuzhou 3
Genova 3
Guatemala City 3
Jieyang 3
Kolkata 3
Kyiv 3
Newton 3
Palmetto 3
Piemonte 3
Porto Alegre 3
Rome 3
Sacile 3
San Francisco 3
Shenyang 3
Shenzhen 3
Silver Spring 3
Upper Marlboro 3
Wroclaw 3
Xiamen 3
Zhengzhou 3
Abuja 2
Ankara 2
Anyang-si 2
Athens 2
Baotou 2
Bromsgrove 2
Chandigarh 2
Concepción 2
Cupertino 2
Delhi 2
Frankfurt am Main 2
Fukushima 2
Genoa 2
Ghaziabad 2
Greifswald 2
Guangzhou 2
Hebei 2
Homburg 2
Istanbul 2
Izmir 2
Iztapalapa 2
Jinan 2
Kumar 2
Lausanne 2
Ludhiana 2
Macao 2
Maitland 2
Totale 1.759
Salva come PNG Salva come JPEG
Nome #
Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3β inhibitors 115
Advanced analytical methodologies in Alzheimer's disease drug discovery 100
3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease 98
Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors 93
Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimers Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography 82
Investigating in vitro amyloid peptide 1−42 aggregation: Impact of higher molecular weight stable adducts 79
Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids 78
A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors 74
(±)- BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease 63
Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice 61
Amaryllidaceae Alkaloids as Potential Glycogen Synthase Kinase-3β Inhibitors 52
Naturally inspired molecules as multifunctional agents for Alzheimer's disease treatment 52
Development and validation of an LC-ESI-MS/MS method for the quantification of D-84, reboxetine and citalopram for their use in MS Binding Assays addressing the monoamine transporters hDAT, hSERT and hNET 52
Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6 52
Development of an UHPLC-diode arrays detector (DAD) method for the analysis of polydatin in human plasma 52
Circular dichroism in drug discovery and development: an abridged review 49
Amyloid beta-Peptide 25-35 Self Assembly and Its Inhibition: A Model Undecapeptide System to Gain Atomistic and Secondary Structure Details of the Alzheimer's Disease Process and Treatment 49
Designing Dual Transglutaminase 2/Histone Deacetylase Inhibitors Effective at Halting Neuronal Death 48
Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer's disease targets 46
Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease 45
Beta-secretase as a target for Alzheimer's disease drug discovery: an overview of in vitro methods for characterization of inhibitors 43
Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer's Disease 43
Direct determination of GSK-3β activity and inhibition by UHPLC-UV-vis diode arrays detector (DAD) 41
Application of an ESI-QTOF method for the detailed characterization of GSK-3β inhibitors 39
Design, synthesis, in silico and in vitro screening of 1,2,4-thiadiazole analogues as non-peptide inhibitors of beta-secretase 39
A patent review of butyrylcholinesterase inhibitors and reactivators 2010–2017 39
Combined Methodologies for Determining In Vitro Bioavailability of Drugs and Prediction of In Vivo Bioequivalence From Pharmaceutical Oral Formulations 39
Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer’s disease 38
Uleine disrupts key enzymatic and non-enzymatic biomarkers that leads to Alzheimer's disease 38
PROTAC-Induced Glycogen Synthase Kinase 3β Degradation as a Potential Therapeutic Strategy for Alzheimer's Disease 37
A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: structure-based design, synthesis, and biological evaluation 37
Natural products as novel scaffolds for the design of glycogen synthase kinase 3β inhibitors 36
Aβ1-42 peptide toxicity on neuronal cells: A lipidomic study 34
From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold 34
Protein Flexibility in Virtual Screening: The BACE-1 Case Study 32
Hydroxy-substituted trans-cinnamoyl derivatives as multifunctional tools in the context of Alzheimer's disease 31
Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents 31
Human recombinant beta-secretase immobilized enzyme reactor for fast hits’ selection and characterization from a virtual screening library 31
Tacrine-based Multifunctional Agents in Alzheimer's Disease: an Old Story in Continuous Development 30
Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease 30
Structural characterization of recombinant therapeutic proteins by circular dichroism 28
Simultaneous Multiple MS Binding Assays for the Dopamine, Norepinephrine, and Serotonin Transporters 28
Pyridinylimidazoles as GSK3β Inhibitors: The Impact of Tautomerism on Compound Activity via Water Networks 27
Multifunctional activity of some isoquinoline alkaloids from Corydalis cava tubers on Alzheimer's disease targets 27
Reversible human serum albumin binding of lipocrine: a circular dichroism study 27
Functionalized aromatic esters of the Amaryllidaceae alkaloid haemanthamine and their in vitro and in silico biological activity connected to Alzheimer's disease 27
Multi-target neuroprotective effects of herbal medicines for Alzheimer's disease 27
- The role of Chromatography in Alzheimer’s Disease Drug Discovery 26
Surface plasmon resonance, fluorescence, and circular dichroism studies for the characterization of the binding of BACE-1 inhibitors 26
Integrated analytical approaches for the characterization of Spirulina and Chlorella microalgae 25
Glycogen Synthase Kinase 3β: A New Gold Rush in Anti-Alzheimer's Disease Multitarget Drug Discovery? 25
From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects 25
Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer 24
Fentanyl pharmacokinetics in blood of cancer patients by Gas Chromatography - Mass Spectrometry 24
Histone Deacetylase Inhibitors as Multitarget Ligands: New Players in Alzheimer's Disease Drug Discovery? 23
Immobilized Enzyme Reactors: an Overview of Applications in Drug Discovery from 2008 to 2018 22
Structural characterization of p53 isoforms due to the polymorphism at codon 72 by Mass Spectrometry and Circular Dichroism 21
Liquid chromatographic enzymatic studies with on-line Beta-secretase immobilized enzyme reactor and 4-(4-dimethylaminophenylazo) benzoic acid/5-[(2-aminoethyl) amino] naphthalene-1-sulfonic acid as fluorogenic substrate 20
Optical Biosensors and Applications to Drug Discovery and Development in Cancer Research 19
Safety issues in nutraceutical exploitation of Chlorella vulgaris, Arthrospira Platensis and Scenedesmus sp. microalgae 15
First in Class Dual Non-ATP-Competitive Glycogen Synthase Kinase 3β/Histone Deacetylase Inhibitors as a Potential Therapeutic to Treat Alzheimer’s Disease 10
Phenolic and Antioxidant Characterization of Fruit By-Products for Their Nutraceuticals and Dietary Supplements Valorization under a Circular Bio-Economy Approach 7
Hit Identification and Functional Validation of Novel Dual Inhibitors of HDAC8 and Tubulin Identified by Combining Docking and Molecular Dynamics Simulations 7
Design of Experiments and Optimization of Monacolin K Green Extraction from Red Yeast Rice by Ultra-High-Performance Liquid Chromatography 6
Integrating a quinone substructure into histone deacetylase inhibitors to cope with Alzheimer's disease and cancer 5
Stepwise Structural Simplification of the Dihydroxyanthraquinone Moiety of a Multitarget Rhein-Based Anti-Alzheimer Lead to Improve Drug Metabolism and Pharmacokinetic Properties 4
Totale 2.587
Salva come PNG Salva come JPEG
Categoria #
all - tutte 11.268
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 11.268
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/202084 0 0 0 0 0 0 0 0 8 20 50 6
2020/2021137 7 17 5 6 17 9 8 13 9 6 2 38
2021/2022316 10 4 17 17 25 7 14 19 15 11 12 165
2022/2023691 97 52 29 69 70 159 65 35 52 10 36 17
2023/2024396 62 62 25 24 15 28 21 18 2 54 27 58
2024/2025802 13 42 25 79 335 180 28 36 64 0 0 0
Totale 2.587