CINECA IRIS Institutional Research Information System

DE SIMONE, Angela
 Distribuzione geografica
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Continente #
NA - Nord America 2.062
AS - Asia 1.718
EU - Europa 731
SA - Sud America 275
AF - Africa 36
OC - Oceania 3
Continente sconosciuto - Info sul continente non disponibili 2
Totale 4.827
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Nazione #
US - Stati Uniti d'America 2.011
SG - Singapore 706
CN - Cina 401
BR - Brasile 208
VN - Vietnam 201
IT - Italia 199
IE - Irlanda 180
IN - India 106
FR - Francia 87
HK - Hong Kong 81
DE - Germania 59
KR - Corea 50
GB - Regno Unito 32
AR - Argentina 26
CA - Canada 26
ID - Indonesia 26
FI - Finlandia 23
BD - Bangladesh 22
NL - Olanda 22
SE - Svezia 21
JP - Giappone 20
IR - Iran 19
ES - Italia 18
IQ - Iraq 18
GR - Grecia 14
TR - Turchia 13
EC - Ecuador 12
MX - Messico 12
RU - Federazione Russa 10
AT - Austria 9
PK - Pakistan 9
CL - Cile 7
PL - Polonia 7
TW - Taiwan 7
HU - Ungheria 6
UA - Ucraina 6
UZ - Uzbekistan 6
ET - Etiopia 5
PY - Paraguay 5
RO - Romania 5
SA - Arabia Saudita 5
TH - Thailandia 5
CH - Svizzera 4
CO - Colombia 4
CZ - Repubblica Ceca 4
DK - Danimarca 4
DZ - Algeria 4
EG - Egitto 4
JO - Giordania 4
NO - Norvegia 4
PE - Perù 4
PH - Filippine 4
UY - Uruguay 4
VE - Venezuela 4
ZA - Sudafrica 4
AE - Emirati Arabi Uniti 3
AU - Australia 3
GT - Guatemala 3
JM - Giamaica 3
MO - Macao, regione amministrativa speciale della Cina 3
PT - Portogallo 3
TN - Tunisia 3
AD - Andorra 2
AL - Albania 2
AO - Angola 2
BF - Burkina Faso 2
IL - Israele 2
KE - Kenya 2
KG - Kirghizistan 2
MA - Marocco 2
NG - Nigeria 2
RS - Serbia 2
AM - Armenia 1
BA - Bosnia-Erzegovina 1
BG - Bulgaria 1
BJ - Benin 1
BO - Bolivia 1
BS - Bahamas 1
BW - Botswana 1
CG - Congo 1
CI - Costa d'Avorio 1
CR - Costa Rica 1
CW - ???statistics.table.value.countryCode.CW??? 1
DO - Repubblica Dominicana 1
GE - Georgia 1
HN - Honduras 1
HR - Croazia 1
IS - Islanda 1
LC - Santa Lucia 1
LT - Lituania 1
LV - Lettonia 1
MT - Malta 1
MW - Malawi 1
NI - Nicaragua 1
NP - Nepal 1
OM - Oman 1
PR - Porto Rico 1
PS - Palestinian Territory 1
SD - Sudan 1
SK - Slovacchia (Repubblica Slovacca) 1
Totale 4.826
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Città #
Santa Clara 411
Singapore 392
Chandler 277
Dublin 179
San Jose 139
Beijing 108
Dallas 101
Ashburn 79
Medford 74
Hong Kong 70
Hanoi 62
Columbus 55
Princeton 54
The Dalles 54
Lauterbourg 53
Ho Chi Minh City 51
Los Angeles 45
Seoul 41
Hefei 38
Wilmington 36
Torino 34
Turin 25
Fairfield 23
Buffalo 21
Shanghai 20
Bologna 17
Council Bluffs 17
Dong Ket 17
Helsinki 17
Redondo Beach 17
Hangzhou 16
Milan 16
Redwood City 16
Tokyo 16
Cambridge 15
Frankfurt am Main 15
Bengaluru 14
Haiphong 13
São Paulo 13
Jakarta 12
Nuremberg 12
Salvador 12
Boston 11
Da Nang 11
Chengdu 10
Chennai 10
Houston 10
Central District 9
Dhaka 9
London 9
Munich 9
Rio de Janeiro 9
Hyderabad 8
Seattle 8
Tehran 8
Toronto 8
Vancouver 8
Guayaquil 7
New Delhi 7
Norwalk 7
Nyköping 7
Orem 7
San Francisco 7
Washington 7
Woodbridge 7
Ann Arbor 6
Bexley 6
Kolkata 6
Kunming 6
Nanjing 6
Pune 6
Xian 6
Addis Ababa 5
Barcelona 5
Mexico City 5
Montreal 5
New York 5
Porto Alegre 5
San Diego 5
Shenzhen 5
Siliguri 5
Szeged 5
Tashkent 5
Amman 4
Athens 4
Baghdad 4
Basrah 4
Curitiba 4
Genoa 4
Istanbul 4
Juiz de Fora 4
Jülich 4
Kyiv 4
Lappeenranta 4
Leinì 4
Madrid 4
Montevideo 4
Sambalpur 4
Silver Spring 4
Zhengzhou 4
Totale 3.055
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Nome #
Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3β inhibitors 185
3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease 176
Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors 171
Advanced analytical methodologies in Alzheimer's disease drug discovery 146
A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors 139
Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimers Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography 132
Investigating in vitro amyloid peptide 1−42 aggregation: Impact of higher molecular weight stable adducts 120
(±)- BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease 120
PROTAC-Induced Glycogen Synthase Kinase 3β Degradation as a Potential Therapeutic Strategy for Alzheimer's Disease 118
Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids 109
Circular dichroism in drug discovery and development: an abridged review 99
Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice 99
Amaryllidaceae Alkaloids as Potential Glycogen Synthase Kinase-3β Inhibitors 93
Amyloid beta-Peptide 25-35 Self Assembly and Its Inhibition: A Model Undecapeptide System to Gain Atomistic and Secondary Structure Details of the Alzheimer's Disease Process and Treatment 93
Naturally inspired molecules as multifunctional agents for Alzheimer's disease treatment 92
Integrated analytical approaches for the characterization of Spirulina and Chlorella microalgae 88
Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6 83
Beta-secretase as a target for Alzheimer's disease drug discovery: an overview of in vitro methods for characterization of inhibitors 81
Direct determination of GSK-3β activity and inhibition by UHPLC-UV-vis diode arrays detector (DAD) 80
Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer's disease targets 78
Aβ1-42 peptide toxicity on neuronal cells: A lipidomic study 77
Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease 77
Development of an UHPLC-diode arrays detector (DAD) method for the analysis of polydatin in human plasma 77
First in Class Dual Non-ATP-Competitive Glycogen Synthase Kinase 3β/Histone Deacetylase Inhibitors as a Potential Therapeutic to Treat Alzheimer’s Disease 75
Design, synthesis, in silico and in vitro screening of 1,2,4-thiadiazole analogues as non-peptide inhibitors of beta-secretase 75
Combined Methodologies for Determining In Vitro Bioavailability of Drugs and Prediction of In Vivo Bioequivalence From Pharmaceutical Oral Formulations 75
Natural products as novel scaffolds for the design of glycogen synthase kinase 3β inhibitors 73
A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: structure-based design, synthesis, and biological evaluation 72
Designing Dual Transglutaminase 2/Histone Deacetylase Inhibitors Effective at Halting Neuronal Death 71
Development and validation of an LC-ESI-MS/MS method for the quantification of D-84, reboxetine and citalopram for their use in MS Binding Assays addressing the monoamine transporters hDAT, hSERT and hNET 69
Application of an ESI-QTOF method for the detailed characterization of GSK-3β inhibitors 68
Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer's Disease 68
A patent review of butyrylcholinesterase inhibitors and reactivators 2010–2017 66
Functionalized aromatic esters of the Amaryllidaceae alkaloid haemanthamine and their in vitro and in silico biological activity connected to Alzheimer's disease 65
From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold 63
Phenolic and Antioxidant Characterization of Fruit By-Products for Their Nutraceuticals and Dietary Supplements Valorization under a Circular Bio-Economy Approach 62
Multi-target neuroprotective effects of herbal medicines for Alzheimer's disease 61
Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer’s disease 60
Fentanyl pharmacokinetics in blood of cancer patients by Gas Chromatography - Mass Spectrometry 59
Human recombinant beta-secretase immobilized enzyme reactor for fast hits’ selection and characterization from a virtual screening library 58
- The role of Chromatography in Alzheimer’s Disease Drug Discovery 57
Pyridinylimidazoles as GSK3β Inhibitors: The Impact of Tautomerism on Compound Activity via Water Networks 57
Hit Identification and Functional Validation of Novel Dual Inhibitors of HDAC8 and Tubulin Identified by Combining Docking and Molecular Dynamics Simulations 56
Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease 54
Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents 54
Structural characterization of recombinant therapeutic proteins by circular dichroism 53
Hydroxy-substituted trans-cinnamoyl derivatives as multifunctional tools in the context of Alzheimer's disease 53
Protein Flexibility in Virtual Screening: The BACE-1 Case Study 53
Uleine disrupts key enzymatic and non-enzymatic biomarkers that leads to Alzheimer's disease 52
Glycogen Synthase Kinase 3β: A New Gold Rush in Anti-Alzheimer's Disease Multitarget Drug Discovery? 51
Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer 51
Simultaneous Multiple MS Binding Assays for the Dopamine, Norepinephrine, and Serotonin Transporters 50
Histone Deacetylase Inhibitors as Multitarget Ligands: New Players in Alzheimer's Disease Drug Discovery? 50
Safety issues in nutraceutical exploitation of Chlorella vulgaris, Arthrospira Platensis and Scenedesmus sp. microalgae 49
Multifunctional activity of some isoquinoline alkaloids from Corydalis cava tubers on Alzheimer's disease targets 49
Tacrine-based Multifunctional Agents in Alzheimer's Disease: an Old Story in Continuous Development 48
Surface plasmon resonance, fluorescence, and circular dichroism studies for the characterization of the binding of BACE-1 inhibitors 47
Reversible human serum albumin binding of lipocrine: a circular dichroism study 44
From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects 44
Integrating a quinone substructure into histone deacetylase inhibitors to cope with Alzheimer's disease and cancer 43
Liquid chromatographic enzymatic studies with on-line Beta-secretase immobilized enzyme reactor and 4-(4-dimethylaminophenylazo) benzoic acid/5-[(2-aminoethyl) amino] naphthalene-1-sulfonic acid as fluorogenic substrate 43
Design of Experiments and Optimization of Monacolin K Green Extraction from Red Yeast Rice by Ultra-High-Performance Liquid Chromatography 41
Optical Biosensors and Applications to Drug Discovery and Development in Cancer Research 40
Immobilized Enzyme Reactors: an Overview of Applications in Drug Discovery from 2008 to 2018 40
Structural characterization of p53 isoforms due to the polymorphism at codon 72 by Mass Spectrometry and Circular Dichroism 40
Stepwise Structural Simplification of the Dihydroxyanthraquinone Moiety of a Multitarget Rhein-Based Anti-Alzheimer Lead to Improve Drug Metabolism and Pharmacokinetic Properties 35
AR-A014418-based dual Glycogen Synthase Kinase 3β/Histone Deacetylase inhibitors as potential therapeutics for Alzheimer's disease 25
BACE-1 Inhibition for the Treatment of Neurodegenerative Diseases: Rationale, Assay Methodologies, and Reference Compounds. 12
Calcium as a molecular switch that regulates Annexin A11 N- and C-terminal domains interaction and its role in ALS 12
Toward Integrative Predictive Toxicology: Advanced Methods for Drug Toxicity and Safety Prediction 4
Totale 4.980
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Categoria #
all - tutte 19.046
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 19.046
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202140 0 0 0 0 0 0 0 0 0 0 2 38
2021/2022316 10 4 17 17 25 7 14 19 15 11 12 165
2022/2023691 97 52 29 69 70 159 65 35 52 10 36 17
2023/2024396 62 62 25 24 15 28 21 18 2 54 27 58
2024/20251.188 13 42 25 79 335 180 28 36 121 70 101 158
2025/20262.007 136 126 245 296 207 99 302 125 200 199 72 0
Totale 4.980