DE SIMONE, Angela
 Distribuzione geografica
Continente #
NA - Nord America 848
EU - Europa 400
AS - Asia 319
SA - Sud America 8
AF - Africa 2
Totale 1.577
Nazione #
US - Stati Uniti d'America 840
CN - Cina 191
IE - Irlanda 175
IT - Italia 121
IN - India 39
VN - Vietnam 23
SG - Singapore 22
SE - Svezia 20
DE - Germania 17
HK - Hong Kong 14
GR - Grecia 12
GB - Regno Unito 11
ES - Italia 8
FR - Francia 7
KR - Corea 7
BR - Brasile 6
IR - Iran 6
HU - Ungheria 5
CA - Canada 4
CZ - Repubblica Ceca 4
IQ - Iraq 4
PL - Polonia 4
TR - Turchia 4
TW - Taiwan 4
UA - Ucraina 4
DK - Danimarca 3
GT - Guatemala 3
MO - Macao, regione amministrativa speciale della Cina 3
CL - Cile 2
NG - Nigeria 2
NO - Norvegia 2
AD - Andorra 1
AM - Armenia 1
BG - Bulgaria 1
MX - Messico 1
NL - Olanda 1
PK - Pakistan 1
RO - Romania 1
RS - Serbia 1
RU - Federazione Russa 1
SK - Slovacchia (Repubblica Slovacca) 1
Totale 1.577
Città #
Chandler 277
Dublin 174
Medford 74
Beijing 69
Princeton 54
Wilmington 36
Torino 34
Ashburn 24
Fairfield 23
Dong Ket 17
Redwood City 16
Bologna 15
Cambridge 15
Hangzhou 15
Shanghai 15
Boston 9
Central District 9
Chengdu 8
Houston 8
Chennai 7
Hefei 7
Norwalk 7
Nyköping 7
Seattle 7
Turin 7
Woodbridge 7
Ann Arbor 6
Kunming 6
London 6
Xian 6
Hong Kong 5
Pune 5
Singapore 5
Szeged 5
Basrah 4
Hyderabad 4
Leinì 4
Milan 4
Nanjing 4
Salvador 4
Seoul 4
Amroha 3
Genova 3
Guatemala City 3
Jieyang 3
Kyiv 3
Piemonte 3
Rome 3
Sacile 3
Shenzhen 3
Toronto 3
Upper Marlboro 3
Wroclaw 3
Xiamen 3
Abuja 2
Ankara 2
Athens 2
Baotou 2
Bromsgrove 2
Chandigarh 2
Concepción 2
Cupertino 2
Delhi 2
Genoa 2
Ghaziabad 2
Greifswald 2
Guangzhou 2
Hebei 2
Homburg 2
Izmir 2
Jinan 2
Kumar 2
Los Angeles 2
Ludhiana 2
Macao 2
Moncalieri 2
Mountain View 2
Nanchang 2
Nerviano 2
Oslo 2
Palermo 2
Pamplona 2
Pistoia 2
Prague 2
San Diego 2
San Francisco 2
Surat 2
São Paulo 2
Taipei 2
Thessaloniki 2
Treviso 2
Washington 2
Zhuhai 2
Absecon 1
Alexandria 1
Andorra la Vella 1
Barcelona 1
Berlin 1
Boadilla del Monte 1
Bratislava 1
Totale 1.137
Nome #
Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3β inhibitors 76
3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease 70
Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors 67
Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids 66
Investigating in vitro amyloid peptide 1−42 aggregation: Impact of higher molecular weight stable adducts 61
Advanced analytical methodologies in Alzheimer's disease drug discovery 59
Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimers Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography 53
A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors 45
Naturally inspired molecules as multifunctional agents for Alzheimer's disease treatment 41
Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6 41
Development and validation of an LC-ESI-MS/MS method for the quantification of D-84, reboxetine and citalopram for their use in MS Binding Assays addressing the monoamine transporters hDAT, hSERT and hNET 40
(±)- BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease 40
Amaryllidaceae Alkaloids as Potential Glycogen Synthase Kinase-3β Inhibitors 39
Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice 39
Development of an UHPLC-diode arrays detector (DAD) method for the analysis of polydatin in human plasma 38
Circular dichroism in drug discovery and development: an abridged review 36
Amyloid beta-Peptide 25-35 Self Assembly and Its Inhibition: A Model Undecapeptide System to Gain Atomistic and Secondary Structure Details of the Alzheimer's Disease Process and Treatment 36
Designing Dual Transglutaminase 2/Histone Deacetylase Inhibitors Effective at Halting Neuronal Death 35
Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer's disease targets 34
Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease 34
Beta-secretase as a target for Alzheimer's disease drug discovery: an overview of in vitro methods for characterization of inhibitors 33
Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer's Disease 33
Design, synthesis, in silico and in vitro screening of 1,2,4-thiadiazole analogues as non-peptide inhibitors of beta-secretase 30
Direct determination of GSK-3β activity and inhibition by UHPLC-UV-vis diode arrays detector (DAD) 30
Application of an ESI-QTOF method for the detailed characterization of GSK-3β inhibitors 29
Uleine disrupts key enzymatic and non-enzymatic biomarkers that leads to Alzheimer's disease 28
Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer’s disease 27
Combined Methodologies for Determining In Vitro Bioavailability of Drugs and Prediction of In Vivo Bioequivalence From Pharmaceutical Oral Formulations 27
A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: structure-based design, synthesis, and biological evaluation 26
A patent review of butyrylcholinesterase inhibitors and reactivators 2010–2017 26
Protein Flexibility in Virtual Screening: The BACE-1 Case Study 23
Natural products as novel scaffolds for the design of glycogen synthase kinase 3β inhibitors 23
From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold 22
Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents 21
Aβ1-42 peptide toxicity on neuronal cells: A lipidomic study 20
Tacrine-based Multifunctional Agents in Alzheimer's Disease: an Old Story in Continuous Development 20
Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease 20
Hydroxy-substituted trans-cinnamoyl derivatives as multifunctional tools in the context of Alzheimer's disease 20
Human recombinant beta-secretase immobilized enzyme reactor for fast hits’ selection and characterization from a virtual screening library 20
Simultaneous Multiple MS Binding Assays for the Dopamine, Norepinephrine, and Serotonin Transporters 18
Reversible human serum albumin binding of lipocrine: a circular dichroism study 18
Multifunctional activity of some isoquinoline alkaloids from Corydalis cava tubers on Alzheimer's disease targets 17
Pyridinylimidazoles as GSK3β Inhibitors: The Impact of Tautomerism on Compound Activity via Water Networks 16
Surface plasmon resonance, fluorescence, and circular dichroism studies for the characterization of the binding of BACE-1 inhibitors 16
- The role of Chromatography in Alzheimer’s Disease Drug Discovery 14
Structural characterization of recombinant therapeutic proteins by circular dichroism 14
Functionalized aromatic esters of the Amaryllidaceae alkaloid haemanthamine and their in vitro and in silico biological activity connected to Alzheimer's disease 14
Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer 14
Histone Deacetylase Inhibitors as Multitarget Ligands: New Players in Alzheimer's Disease Drug Discovery? 13
Immobilized Enzyme Reactors: an Overview of Applications in Drug Discovery from 2008 to 2018 12
Liquid chromatographic enzymatic studies with on-line Beta-secretase immobilized enzyme reactor and 4-(4-dimethylaminophenylazo) benzoic acid/5-[(2-aminoethyl) amino] naphthalene-1-sulfonic acid as fluorogenic substrate 11
Structural characterization of p53 isoforms due to the polymorphism at codon 72 by Mass Spectrometry and Circular Dichroism 11
Optical Biosensors and Applications to Drug Discovery and Development in Cancer Research 10
Glycogen Synthase Kinase 3β: A New Gold Rush in Anti-Alzheimer's Disease Multitarget Drug Discovery? 10
From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects 10
Multi-target neuroprotective effects of herbal medicines for Alzheimer's disease 10
Fentanyl pharmacokinetics in blood of cancer patients by Gas Chromatography - Mass Spectrometry 10
Integrated analytical approaches for the characterization of Spirulina and Chlorella microalgae 9
PROTAC-Induced Glycogen Synthase Kinase 3β Degradation as a Potential Therapeutic Strategy for Alzheimer's Disease 9
Safety issues in nutraceutical exploitation of Chlorella vulgaris, Arthrospira Platensis and Scenedesmus sp. microalgae 1
Totale 1.685
Categoria #
all - tutte 6.796
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 6.796


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020245 0 0 0 0 0 73 75 13 8 20 50 6
2020/2021137 7 17 5 6 17 9 8 13 9 6 2 38
2021/2022316 10 4 17 17 25 7 14 19 15 11 12 165
2022/2023691 97 52 29 69 70 159 65 35 52 10 36 17
2023/2024296 62 62 25 24 15 28 21 18 2 39 0 0
Totale 1.685