OLIARO BOSSO, Simonetta
OLIARO BOSSO, Simonetta
SCIENZA E TECNOLOGIA DEL FARMACO
4-methyl zymosterone and other 4-methyl intermediates of sterol biosynthesis from yeast mutants engineered in the ERG27 gene encoding 3-ketosteroid reductase
2015-01-01 Ferrante, Terenzio; Barge, Alessandro; Albezzano, Claudia; Ballestrazzi Clara; Balliano, Gianni; Oliaro-Bosso, Simonetta
A mutation in yeast oxidosqualene cyclase (Erg7) makes it independent of 3-ketoreductase activity (Erg27)
2012-01-01 Layer Jacob V; Barnes Brett M; Yamasaki Yuji; Barbuch Robert; Li Lingtao; Taramino Silvia; Oliaro-Bosso Simonetta; Balliano Gianni; Bard Martin
A new generation of AKR1C3 inhibitors on the horizon: the 3- hydroxybenzazole approach to target prostate cancer
2023-01-01 Chiara Vigato, Agnese Chiara Pippione, Stefano Sainas, Iole Mannella, Laura Bertarini, Sandra Kovachka, Barbara Rolando, Osman Asghar Mirza, Karla Frydenvang, Francesca Spyrakis, Simonetta Oliaro-Bosso, Marco Lucio Lolli, Donatella Boschi
Access of the substrate to the active site of yeast oxidosqualene cyclase: a modelling and site-directed mutagenesis approach
2009-01-01 S. Oliaro-Bosso; S. Taramino; Y. Ferrari; G. Ermondi; G. Caron; F. Viola; G. Balliano
Access of the substrate to the active site of yeast oxidosqualene cyclase: an inhibition and site-directed mutagenesis appoach.
2004-01-01 OLIARO-BOSSO S.; SCALDAFERRI M.; TARAMINO S.; F. VIOLA; G. BALLIANO
Access of the substrate to the active site of yeast oxidosqualene cyclase: an inhibition and site-directed mutagenesis approach.
2005-01-01 Balliano G.; Oliaro-Bosso S.; Taramino S.; Viola F
Application of an in house bioisosteric approach to the design of innovative inhibitors of aldo-keto reductase 1C3 (AKR1C3)
2019-01-01 Chiara Vigato, Agnese Chiara Pippione, Sandra Kovachka, Francesca Spyrakis, Martina Daga, Simonetta Oliaro-Bosso, Marco Lucio Lolli, Donatella Boschi
Application of an in house bioisosteric approach to the design of innovative inhibitors of aldo-keto reductase 1C3 (AKR1C3)
2019-01-01 Chiara Vigato, Agnese Chiara Pippione, Sandra Kovachka, Francesca Spyrakis, Martina Daga, Simonetta Oliaro Bosso, Marco Lucio Lolli, Donatella Boschi
Characterization of C-4 demethylation complex of cholesterol biosynthesis
2012-01-01 Brozzu Andrea; Oliaro-Bosso Simonetta; Zonari Daniele; Viola Franca; Poirier Donald; Cunningham David; Herman Gail; Jokela Heili; Poutanen Matti; Balliano Gianni
Comparative characterization of yeast and human 3-ketosteroid reductase, two moonlighting proteins that share a job
2015-01-01 Ferrante, Terenzio; Remani, Elisa; Baratta, Erica; Poirier, Donald; Balliano, Gianni; Oliaro-Bosso, Simonetta
Design, synthesis, and biological evaluation of flufenamic acid derived bioisosteres as inhibitors of aldo-keto reductase 1C3 (AKR1C3) expressed in prostate cancer
2016-01-01 Lolli, Marco; Cena, Clara; Giraudo, Alessandro; Marini, Elisabetta; Pippione, Agnese; Oliaro-Bosso, Simonetta; Ferrante, Terenzio; Sadiq, Maria; Pors, Klaus; Boschi, Donatella; Braga, Rudolpho; Andrade, Carolina.
Different interaction between oxidosqualene cyclase and steroid-3-ketoreductase from yeasts to mammals
2011-01-01 S. Taramino; B. Teske; S. Oliaro-Bosso; F. Viola; M. Bard; G. Balliano
Different Interaction between Oxidosqualene Cyclase and Steroid-3-ketoreductase in Yeast and Mammals
2010-01-01 Silvia Taramino; Brian Teske; Simonetta Oliaro-Bosso; Franca Viola; Martin Bard; Gianni Balliano
Effect of inhibiting the sterol biosynthesis pathway and the cholesterol content in the regulation of angiogenesis in vitro and in vivo
2011-01-01 Claudia Meda; Simonetta Oliaro-Bosso; Marina Visentin; Carlo Cerato; Valmira Lena; Federico Bussolino; Gianni Balliano; Franca Viola; Enrico Giraudo
Effects of new hydroxyazoles inhibitors of AKR1C3 on vitality of prostate and colorectal cancer cell lines
2019-01-01 Valentina Boscaro, Donatella Boschi, Simonetta Oliaro-Bosso, Martina Daga, Marco Lolli, Agnese Chiara Pippione, Margherita Gallicchio
Exploring the access of the substrate to the active site of yeast oxidosqualene cyclase by site-directed mutagenesis
2007-01-01 S. Oliaro-Bosso; S. Taramino; I. Ferrari; G. Ermondi; G. Caron; F. Viola; G. Balliano
Exploring the access of the substrate to the active site of yeast oxidosqualene cyclase by site-directed mutagenesis.
2007-01-01 S. Oliaro-Bosso; S. Taramino; I. Ferrari; G. Ermondi; G. Caron; F. Viola; G. Balliano
Functional characterization by site-directed mutagenesis of human oxidosqualene cyclase (OSC) expressed in Pichia pastoris
2012-01-01 Viola Franca; Balliano Gianni; Ruf Armin; Taramino Silvia; di Bartolo Giuseppe; Oliaro-Bosso Simonetta
HYDROXYLATED HETEROCYCLES AS BIOISOSTERES OF THE CARBOXYLIC FUNCTION: DESIGN OF NEW AKR1C3 INHIBITORS ACTIVE IN PROSTATE CANCER
2023-01-01 Agnese C. Pippione, Stefano Sainas, Chiara Vigato, Iole Mannella, Irene Castellino, Sandra Kovachka, Mariia Iakovleva, Barbara Rolando, Tomasz Wrobel, Osman A. Mirza, Karla Frydenvang, Francesca Spyrakis, Simonetta Oliaro-Bosso, Marco L. Lolli, Donatella Boschi
Interaction of oxidosqualene cyclase with C-4 sterol demethylation complex
2009-01-01 S. Taramino; M. Valachovic; S. Oliaro-Bosso; F. Viola; B. Teske; M. Bard; G. Balliano
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| 4-methyl zymosterone and other 4-methyl intermediates of sterol biosynthesis from yeast mutants engineered in the ERG27 gene encoding 3-ketosteroid reductase | 2015 | Ferrante, Terenzio; Barge, Alessandro; Albezzano, Claudia; Ballestrazzi Clara; Balliano, Gianni; Oliaro-Bosso, Simonetta | |
| A mutation in yeast oxidosqualene cyclase (Erg7) makes it independent of 3-ketoreductase activity (Erg27) | 2012 | Layer Jacob V; Barnes Brett M; Yamasaki Yuji; Barbuch Robert; Li Lingtao; Taramino Silvia; Oliaro-Bosso Simonetta; Balliano Gianni; Bard Martin | |
| A new generation of AKR1C3 inhibitors on the horizon: the 3- hydroxybenzazole approach to target prostate cancer | 2023 | Chiara Vigato, Agnese Chiara Pippione, Stefano Sainas, Iole Mannella, Laura Bertarini, Sandra Kovachka, Barbara Rolando, Osman Asghar Mirza, Karla Frydenvang, Francesca Spyrakis, Simonetta Oliaro-Bosso, Marco Lucio Lolli, Donatella Boschi | |
| Access of the substrate to the active site of yeast oxidosqualene cyclase: a modelling and site-directed mutagenesis approach | 2009 | S. Oliaro-Bosso; S. Taramino; Y. Ferrari; G. Ermondi; G. Caron; F. Viola; G. Balliano | |
| Access of the substrate to the active site of yeast oxidosqualene cyclase: an inhibition and site-directed mutagenesis appoach. | 2004 | OLIARO-BOSSO S.; SCALDAFERRI M.; TARAMINO S.; F. VIOLA; G. BALLIANO | |
| Access of the substrate to the active site of yeast oxidosqualene cyclase: an inhibition and site-directed mutagenesis approach. | 2005 | Balliano G.; Oliaro-Bosso S.; Taramino S.; Viola F | |
| Application of an in house bioisosteric approach to the design of innovative inhibitors of aldo-keto reductase 1C3 (AKR1C3) | 2019 | Chiara Vigato, Agnese Chiara Pippione, Sandra Kovachka, Francesca Spyrakis, Martina Daga, Simonetta Oliaro-Bosso, Marco Lucio Lolli, Donatella Boschi | |
| Application of an in house bioisosteric approach to the design of innovative inhibitors of aldo-keto reductase 1C3 (AKR1C3) | 2019 | Chiara Vigato, Agnese Chiara Pippione, Sandra Kovachka, Francesca Spyrakis, Martina Daga, Simonetta Oliaro Bosso, Marco Lucio Lolli, Donatella Boschi | |
| Characterization of C-4 demethylation complex of cholesterol biosynthesis | 2012 | Brozzu Andrea; Oliaro-Bosso Simonetta; Zonari Daniele; Viola Franca; Poirier Donald; Cunningham David; Herman Gail; Jokela Heili; Poutanen Matti; Balliano Gianni | |
| Comparative characterization of yeast and human 3-ketosteroid reductase, two moonlighting proteins that share a job | 2015 | Ferrante, Terenzio; Remani, Elisa; Baratta, Erica; Poirier, Donald; Balliano, Gianni; Oliaro-Bosso, Simonetta | |
| Design, synthesis, and biological evaluation of flufenamic acid derived bioisosteres as inhibitors of aldo-keto reductase 1C3 (AKR1C3) expressed in prostate cancer | 2016 | Lolli, Marco; Cena, Clara; Giraudo, Alessandro; Marini, Elisabetta; Pippione, Agnese; Oliaro-Bosso, Simonetta; Ferrante, Terenzio; Sadiq, Maria; Pors, Klaus; Boschi, Donatella; Braga, Rudolpho; Andrade, Carolina. | |
| Different interaction between oxidosqualene cyclase and steroid-3-ketoreductase from yeasts to mammals | 2011 | S. Taramino; B. Teske; S. Oliaro-Bosso; F. Viola; M. Bard; G. Balliano | |
| Different Interaction between Oxidosqualene Cyclase and Steroid-3-ketoreductase in Yeast and Mammals | 2010 | Silvia Taramino; Brian Teske; Simonetta Oliaro-Bosso; Franca Viola; Martin Bard; Gianni Balliano | |
| Effect of inhibiting the sterol biosynthesis pathway and the cholesterol content in the regulation of angiogenesis in vitro and in vivo | 2011 | Claudia Meda; Simonetta Oliaro-Bosso; Marina Visentin; Carlo Cerato; Valmira Lena; Federico Bussolino; Gianni Balliano; Franca Viola; Enrico Giraudo | |
| Effects of new hydroxyazoles inhibitors of AKR1C3 on vitality of prostate and colorectal cancer cell lines | 2019 | Valentina Boscaro, Donatella Boschi, Simonetta Oliaro-Bosso, Martina Daga, Marco Lolli, Agnese Chiara Pippione, Margherita Gallicchio | |
| Exploring the access of the substrate to the active site of yeast oxidosqualene cyclase by site-directed mutagenesis | 2007 | S. Oliaro-Bosso; S. Taramino; I. Ferrari; G. Ermondi; G. Caron; F. Viola; G. Balliano | |
| Exploring the access of the substrate to the active site of yeast oxidosqualene cyclase by site-directed mutagenesis. | 2007 | S. Oliaro-Bosso; S. Taramino; I. Ferrari; G. Ermondi; G. Caron; F. Viola; G. Balliano | |
| Functional characterization by site-directed mutagenesis of human oxidosqualene cyclase (OSC) expressed in Pichia pastoris | 2012 | Viola Franca; Balliano Gianni; Ruf Armin; Taramino Silvia; di Bartolo Giuseppe; Oliaro-Bosso Simonetta | |
| HYDROXYLATED HETEROCYCLES AS BIOISOSTERES OF THE CARBOXYLIC FUNCTION: DESIGN OF NEW AKR1C3 INHIBITORS ACTIVE IN PROSTATE CANCER | 2023 | Agnese C. Pippione, Stefano Sainas, Chiara Vigato, Iole Mannella, Irene Castellino, Sandra Kovachka, Mariia Iakovleva, Barbara Rolando, Tomasz Wrobel, Osman A. Mirza, Karla Frydenvang, Francesca Spyrakis, Simonetta Oliaro-Bosso, Marco L. Lolli, Donatella Boschi | |
| Interaction of oxidosqualene cyclase with C-4 sterol demethylation complex | 2009 | S. Taramino; M. Valachovic; S. Oliaro-Bosso; F. Viola; B. Teske; M. Bard; G. Balliano |