SPYRAKIS, Francesca
 Distribuzione geografica
Continente #
EU - Europa 2.137
NA - Nord America 1.728
AS - Asia 713
AF - Africa 160
SA - Sud America 56
OC - Oceania 48
Continente sconosciuto - Info sul continente non disponibili 1
Totale 4.843
Nazione #
US - Stati Uniti d'America 1.658
IT - Italia 659
DE - Germania 444
FR - Francia 422
IN - India 138
CN - Cina 131
GB - Regno Unito 124
DZ - Algeria 106
CZ - Repubblica Ceca 82
NL - Olanda 62
VN - Vietnam 59
CA - Canada 54
TR - Turchia 53
JP - Giappone 50
AU - Australia 43
RU - Federazione Russa 42
PL - Polonia 41
HK - Hong Kong 39
FI - Finlandia 34
IR - Iran 34
TW - Taiwan 34
BR - Brasile 28
KR - Corea 26
ES - Italia 24
PH - Filippine 24
UA - Ucraina 23
AT - Austria 20
PK - Pakistan 20
SE - Svezia 19
ID - Indonesia 16
RO - Romania 16
SG - Singapore 16
EG - Egitto 15
JO - Giordania 15
DK - Danimarca 14
MX - Messico 13
ZA - Sudafrica 13
CH - Svizzera 12
IQ - Iraq 12
BE - Belgio 11
IE - Irlanda 11
MK - Macedonia 9
MY - Malesia 9
NO - Norvegia 9
PE - Perù 9
RS - Serbia 9
AE - Emirati Arabi Uniti 8
CL - Cile 8
MD - Moldavia 8
CO - Colombia 7
GR - Grecia 6
HU - Ungheria 6
MA - Marocco 6
PT - Portogallo 6
TH - Thailandia 6
YE - Yemen 6
NG - Nigeria 5
NZ - Nuova Zelanda 5
SA - Arabia Saudita 5
EE - Estonia 4
ET - Etiopia 4
GH - Ghana 4
HR - Croazia 4
IL - Israele 4
SK - Slovacchia (Repubblica Slovacca) 4
BD - Bangladesh 3
AL - Albania 2
AR - Argentina 2
BG - Bulgaria 2
EC - Ecuador 2
IS - Islanda 2
KE - Kenya 2
LI - Liechtenstein 2
MO - Macao, regione amministrativa speciale della Cina 2
NP - Nepal 2
SD - Sudan 2
TN - Tunisia 2
A2 - ???statistics.table.value.countryCode.A2??? 1
BA - Bosnia-Erzegovina 1
HN - Honduras 1
LK - Sri Lanka 1
LT - Lituania 1
MT - Malta 1
PA - Panama 1
SI - Slovenia 1
TT - Trinidad e Tobago 1
UG - Uganda 1
Totale 4.843
Città #
Ashburn 180
Fairfield 139
Torino 135
Santa Cruz 124
Turin 91
Oran 86
Houston 82
Seattle 62
Ann Arbor 53
Woodbridge 52
Nürnberg 48
Cambridge 44
Buffalo 43
Dong Ket 39
Wilmington 37
Columbus 36
Milan 36
Council Bluffs 33
Boardman 28
Los Angeles 27
Shanghai 27
New York 22
Helsinki 21
Leawood 21
Modena 21
Rome 21
Zhubei 21
Leeds 20
San Diego 20
Beijing 19
Melbourne 19
Cagliari 18
Chicago 17
San Francisco 17
Uberlândia 17
Warsaw 17
Wuhan 17
Bedford 16
Amman 15
Istanbul 15
Minneapolis 15
Amsterdam 14
Lappeenranta 13
Pisa 12
Tokyo 12
Paris 11
University Park 11
Vienna 11
Bengaluru 10
Changsha 10
Karachi 10
London 10
Marburg 10
Stockholm 10
Taipei 10
Bacolod City 9
Bovenden 9
Central 9
Dearborn 9
Ho Chi Minh City 9
Hyderabad 9
Munich 9
Chennai 8
Chisinau 8
Dallas 8
Henderson 8
Mostaganem 8
Palermo 8
Richmond 8
Ankara 7
Atlanta 7
Belgrade 7
Berlin 7
Des Moines 7
Fleming Island 7
Lake Forest 7
Las Vegas 7
Lima 7
Naples 7
Nuremberg 7
Sydney 7
Athens 6
Aurangabad 6
Baghdad 6
Brooklyn 6
Carini 6
Chandler 6
Decimomannu 6
Delhi 6
Dublin 6
Frankfurt am Main 6
Grahamstown 6
Guangzhou 6
Lethbridge 6
Montreal 6
Mountain View 6
Parma 6
Piacenza 6
Rivoli 6
San Mauro Torinese 6
Totale 2.242
Nome #
Human dopamine transporter: the first implementation of a combined in silico/in vitro approach revealing the substrate and inhibitor specificities, file e27ce42c-a739-2581-e053-d805fe0acbaa 648
BROAD SPECTRUM METALLO beta-LACTAMASES INHIBITORS: NEW TOOLS AGAINST CLINICALLY-RELEVANT CARBAPENEMASES, file a2376517-db0e-47da-b7e5-1c34ca81ce66 510
The Roles of Water in the Protein Matrix: A Largely Untapped Resource for Drug Discovery, file e27ce42f-1a8a-2581-e053-d805fe0acbaa 289
Exploring Ligand Binding Domain Dynamics in the NRs Superfamily, file 939c8c63-5a01-4667-8c78-7698935dc07d 276
Strigolactones as broad-spectrum antivirals against β-coronaviruses through targeting SARS-CoV-2 Mpro, file 5a33bfc9-4e5f-41c7-b8c7-877c9def2780 212
In the search for new NLRP3 inhibitors: chemical modulation of the 1-(piperidin-4-yl)-1,3-dihydro-2 Hbenzo[d]imidazole-2-one scaffold, file 08889351-65f4-45f0-9414-657c773f233e 182
Essential oils bearing specialized metabolites with potential hypoglycemic activity: a bio-guided fractionation approach driven by in vitro (porcine, human and fungal) α-amylase inhibition assays, file 86eb5ec3-ea42-45e8-9cff-30b3110e455e 166
Long period fiber grating working in reflection mode as valuable biosensing platform for the detection of drug resistant bacteria, file e27ce42c-8495-2581-e053-d805fe0acbaa 136
Virtual screening identifies broad-spectrum β-lactamase inhibitors with activity on clinically relevant serine- and metallo-carbapenemases, file e27ce431-4063-2581-e053-d805fe0acbaa 134
CO Rebinding Kinetics and Molecular Dynamics Simulations Highlight Dynamic Regulation of Internal Cavities in Human Cytoglobin, file e27ce42c-493f-2581-e053-d805fe0acbaa 119
Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-beta-lactamases, file e27ce42c-8c77-2581-e053-d805fe0acbaa 92
Rational design of a user-friendly aptamer/peptide-based device for the detection of staphylococcus aureus, file e27ce431-4069-2581-e053-d805fe0acbaa 91
Interaction of human hemoglobin and semi-hemoglobins with the Staphylococcus aureus hemophore IsdB: a kinetic and mechanistic insight, file e27ce42e-d31d-2581-e053-d805fe0acbaa 89
4-amino-1,2,4-triazole-3-thione as a promising scaffold for the inhibition of serine and metallo-β-lactamases, file e27ce42f-c5e8-2581-e053-d805fe0acbaa 89
A new approach for investigating protein flexibility based on Constraint Logic Programming. The first application in the case of the estrogen receptor, file e27ce42c-5e0f-2581-e053-d805fe0acbaa 84
Iron metabolism at the interface between host and pathogen: From nutritional immunity to antibacterial development, file e27ce430-1111-2581-e053-d805fe0acbaa 83
Chemical modulation of the 1-(Piperidin-4-yl)-1,3-dihydro-2h-benzo[d]imidazole-2-one scaffold as a novel NLRP3 inhibitor, file e27ce432-3ce7-2581-e053-d805fe0acbaa 80
Lack of interaction of the fluorosurfactant C6O4 with human renal transporters: In vitro/in silico analysis, file 2f5d75dd-b79f-47cb-b2fa-8ce8319ec873 71
Strigolactone Analogs Are Promising Antiviral Agents for the Treatment of Human Cytomegalovirus Infection., file e27ce42f-cc88-2581-e053-d805fe0acbaa 68
Evaluation of Porcine and Aspergillus oryzae α-Amylases as Possible Model for the Human Enzyme, file 5edb15f4-4f92-475c-9795-1c10370e6bca 65
Isozyme-Specific Ligands for O-acetylserine sulfhydrylase, a Novel Antibiotic Target, file e27ce42c-6721-2581-e053-d805fe0acbaa 62
Label-free fiber optic optrode for the detection of class C beta-lactamases expressed by drug resistant bacteria, file e27ce42c-ad23-2581-e053-d805fe0acbaa 58
Multiple catalytic activities of human 17β-hydroxysteroid dehydrogenase type 7 respond differently to inhibitors., file e27ce42f-993b-2581-e053-d805fe0acbaa 56
Binding of androgen-and estrogen-like flavonoids to their cognate (Non)nuclear receptors: A comparison by computational prediction, file e27ce432-deb1-2581-e053-d805fe0acbaa 56
Tuning the Hydrophobicity of a Mitochondria-Targeted NO Photodonor, file e27ce42c-bcef-2581-e053-d805fe0acbaa 54
Can we exploit β-lactamases intrinsic dynamics for designing more effective inhibitors?, file e27ce431-4a0d-2581-e053-d805fe0acbaa 53
Strigolactones, from Plants to Human Health: Achievements and Challenges, file e27ce432-6e5d-2581-e053-d805fe0acbaa 53
Bound water at protein-protein interfaces: Partners, roles and hydrophobic bubbles as a conserved motif, file e27ce42c-a832-2581-e053-d805fe0acbaa 52
New aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the hydroxytriazole scaffold, file e27ce435-3b91-2581-e053-d805fe0acbaa 50
Comparing Drug Images and Repurposing Drugs with BioGPS and FLAPdock: The Thymidylate Synthase Case, file e27ce42c-dfd9-2581-e053-d805fe0acbaa 48
Energetics of the protein-DNA-water interaction, file e27ce42c-84d5-2581-e053-d805fe0acbaa 46
Repurposing the trypanosomatidic gsk kinetobox for the inhibition of parasitic pteridine and dihydrofolate reductases, file e27ce434-1910-2581-e053-d805fe0acbaa 43
A Pipeline to Enhance Ligand Virtual Screening: Integrating Molecular Dynamics and Fingerprints for Ligand and Proteins, file e27ce42d-0bf4-2581-e053-d805fe0acbaa 38
The Roles of Water in the Protein Matrix: A Largely Untapped Resource for Drug Discovery, file e27ce42c-5a7a-2581-e053-d805fe0acbaa 37
Cryo-EM structures of staphylococcal IsdB bound to human hemoglobin reveal the process of heme extraction, file 4e51e48a-5339-4c2d-bcb4-4dce51e5dddf 36
Comparative analysis of inner cavities and ligand migration in non-symbiotic AHb1 and AHb2, file e27ce42c-ad92-2581-e053-d805fe0acbaa 35
Targeting cystalysin, a virulence factor of Treponema denticola-supported periodontitis, file e27ce42d-1544-2581-e053-d805fe0acbaa 32
From Experiments to a Fast Easy-to-Use Computational Methodology to Predict Human Aldehyde Oxidase Selectivity and Metabolic Reactions, file e27ce433-5b65-2581-e053-d805fe0acbaa 31
Design and synthesis of INF195, a new NLRP3 Inflammasome Inhibitor with ex vivo cardioprotective effect, file 3a4cb05e-80d2-47e9-96f6-605cbb52576e 30
Indomethacin Inhibits Proliferation In Cells Harbouring PIK3CA Mutations, file e27ce42f-25c5-2581-e053-d805fe0acbaa 30
Paracetamol-Galactose Conjugate: A Novel Prodrug for an Old Analgesic Drug, file e27ce435-98a8-2581-e053-d805fe0acbaa 29
Strigolactones as broad-spectrum antivirals against β-coronaviruses through targeting the main protease Mpro, file 93237fc6-9590-4e0b-b493-b439f0066fc5 25
Structure Activity Relationship of strigolactones via a novel, quantitative in planta bioassay, file e27ce432-5dc5-2581-e053-d805fe0acbaa 24
Discovery of a novel 1,3,4-oxadiazol-2-one-based NLRP3 inhibitor as a pharmacological agent to mitigate cardiac and metabolic complications in an experimental model of diet-induced metaflammation, file dbbf1cec-92cb-4b59-a79b-a1e7780a8780 22
Strigolactones as antiviral drugs to inhibit Herpesvirus replication, file e27ce42e-92b3-2581-e053-d805fe0acbaa 22
A generator of peroxynitrite activatable with red light, file e27ce432-66d7-2581-e053-d805fe0acbaa 22
Fluorescent Nitric Oxide Photodonors Based on BODIPY and Rhodamine Antennae, file e27ce432-ebba-2581-e053-d805fe0acbaa 22
Strigolactone analogs are promising antiviral agents against Herpesviruses, file e27ce432-2b0d-2581-e053-d805fe0acbaa 19
A structural homologue of the plant receptor D14 mediates responses to strigolactones in the fungal phytopathogen Cryphonectria parasitica, file e27ce435-8b86-2581-e053-d805fe0acbaa 17
Molecular Dynamics and Machine Learning Give Insights on the Flexibility-Activity Relationships in Tyrosine Kinome, file fe8cc9b7-5bb8-4331-a353-c6f6a26583d5 16
Strigolactones as broad-spectrum antivirals against ß-coronaviruses through targeting the main protease Mpro, file 50b2e168-1d22-4721-a7c2-fd8cce39167a 15
Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAFV600E Protein, file d8cded6f-e57e-4e8c-87da-877e19c5510e 15
Ligand migration through hemeprotein cavities: Insights from laser flash photolysis and molecular dynamics simulations, file e27ce42d-036a-2581-e053-d805fe0acbaa 15
Structure-based virtual screening for the discovery of novel inhibitors of New Delhi Metallo-beta-lactamase-1, file e27ce432-f140-2581-e053-d805fe0acbaa 15
Structural insight into the interaction of O-acetylserine sulfhydrylase with competitive, peptidic inhibitors by saturation transfer difference-NMR, file e27ce42d-1543-2581-e053-d805fe0acbaa 14
Strigolactone Analogs Are Promising Antiviral Agents for the Treatment of Human Cytomegalovirus Infection, file e27ce432-fa6f-2581-e053-d805fe0acbaa 13
The EU’s Per- and Polyfluoroalkyl Substances (PFAS) Ban: A Case of Policy over Science, file 925fe2a0-54be-4584-bdd0-fa6af748a123 12
Fluorescent Nitric Oxide Photodonors Based on BODIPY and Rhodamine Antennae, file e27ce42e-af49-2581-e053-d805fe0acbaa 12
Paracetamol-Galactose Conjugate: A Novel Prodrug for an Old Analgesic Drug, file e27ce42e-df97-2581-e053-d805fe0acbaa 12
A Blueprint for High Affinity SARS-CoV-2 Mpro Inhibitors from Activity-Based Compound Library Screening Guided by Analysis of Protein Dynamics, file e27ce432-c0c0-2581-e053-d805fe0acbaa 12
Strigolactone analogs are promising antiviral agents for the treatment of human cytomegalovirus infection, file e27ce432-db35-2581-e053-d805fe0acbaa 11
HINT, a code for understanding the interaction between biomolecules: a tribute to Donald J. Abraham, file a322738e-cb88-48f4-830c-3a76af636d9e 10
A Pipeline to Enhance Ligand Virtual Screening: Integrating Molecular Dynamics and Fingerprints for Ligand and Proteins, file e27ce42c-5c4f-2581-e053-d805fe0acbaa 8
Folic Acid-Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting, file e27ce432-f522-2581-e053-d805fe0acbaa 8
Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer, file 95bb6e43-8fbf-4e81-8b56-6ed88d7a749f 7
Fine tuning of the active site modulates specificity in the interaction of O-acetylserine sulfhydrylase isozymes with serine acetyltransferase, file e27ce42c-5cbf-2581-e053-d805fe0acbaa 7
Cryo-EM undiscloses structural and mechanistic details on iron hijacking by Staphylococcus aureus: An insight into the interaction of IsdB hemophore with human hemoglobin, file 8857b9d2-5e3b-4ded-b2fb-7f8eabec9fff 6
Recent advances in the synthesis of analogues of phytohormones strigolactones with ring-closing metathesis as a key step, file e27ce42c-7f6c-2581-e053-d805fe0acbaa 6
Multiple catalytic activities of human 17β-hydroxysteroid dehydrogenase type 7 respond differently to inhibitors., file e27ce42f-017f-2581-e053-d805fe0acbaa 6
Computational Modeling and Design of New Inhibitors of Carbapenemases: A Discussion from the EPIC Alliance Network, file 5891188b-dcbb-4924-936b-bcd2f43359d9 5
N-[1,3-Dialkyl(aryl)-2-oxoimidazolidin-4-ylidene]-aryl(alkyl)sulphonamides as Novel Selective Human Cannabinoid Type 2 Receptor (hCB2R) Ligands; Insights into the Mechanism of Receptor Activation/Deactivation, file e260b6d2-2b05-4664-b2f5-644d7b2e365f 5
Structure Activity Relationship of strigolactones via a novel, quantitative in planta bioassay, file e27ce42c-ac06-2581-e053-d805fe0acbaa 5
Fluorescent Nitric Oxide Photodonors Based on BODIPY and Rhodamine Antennae, file e27ce42e-a491-2581-e053-d805fe0acbaa 5
Antiherpetic Activity of a Root Exudate from Solanum lycopersicum [*Valentina Dell'Oste, Marco Blangetti co-corresponding authors; † Greta Bajetto, Davide Arnodo co-first authors], file f2e61f1a-3b1b-4528-9f3e-b79896f136ea 5
Comparing Drug Images and Repurposing Drugs with BioGPS and FLAPdock: The Thymidylate Synthase Case, file e27ce42c-73ed-2581-e053-d805fe0acbaa 4
Ligand migration through hemeprotein cavities: Insights from laser flash photolysis and molecular dynamics simulations, file e27ce42c-80ef-2581-e053-d805fe0acbaa 4
The Roles of Water in the Protein Matrix: A Largely Untapped Resource for Drug Discovery, file e27ce42c-9d1d-2581-e053-d805fe0acbaa 4
A community effort in SARS-CoV-2 drug discovery, file 4ce93cf4-ba26-4163-b0af-31048d420b2a 3
Structure-Based Optimization of 1,2,4-Triazole-3-Thione Derivatives: Improving Inhibition of NDM-/VIM-Type Metallo-beta -Lactamases and Synergistic Activity on Resistant Bacteria, file 7cb2c1bb-e4c6-4082-9833-e6a555fd4c89 3
Targeting cystalysin, a virulence factor of Treponema denticola-supported periodontitis, file e27ce42c-6bef-2581-e053-d805fe0acbaa 3
Structural insight into the interaction of O-acetylserine sulfhydrylase with competitive, peptidic inhibitors by saturation transfer difference-NMR, file e27ce42c-a834-2581-e053-d805fe0acbaa 3
Tuning the Hydrophobicity of a Mitochondria-Targeted NO Photodonor, file e27ce42c-fa2c-2581-e053-d805fe0acbaa 3
New aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the hydroxytriazole scaffold, file e27ce435-3998-2581-e053-d805fe0acbaa 3
NLRP3 monomer functional dynamics: From the effects of allosteric binding to implications for drug design, file 627f5829-1cdf-4147-8da2-1e385d1dfbd8 2
HYDROXYLATED HETEROCYCLES AS BIOISOSTERES OF THE CARBOXYLIC FUNCTION: DESIGN OF NEW AKR1C3 INHIBITORS ACTIVE IN PROSTATE CANCER, file deffeefd-18ce-465e-8214-ab55208f9682 2
Theoretical calculations of the catalytic triad in short-chain alcohol dehydrogenases/reductases, file e27ce42c-4516-2581-e053-d805fe0acbaa 2
Energy-based prediction of amino acid-nucleotide base recognition, file e27ce42c-6c62-2581-e053-d805fe0acbaa 2
Comparing Drug Images and Repurposing Drugs with BioGPS and FLAPdock: The Thymidylate Synthase Case, file e27ce42c-6c65-2581-e053-d805fe0acbaa 2
FADB: A food additive molecular database for in silico screening in food toxicology, file e27ce42c-754b-2581-e053-d805fe0acbaa 2
Ligand migration through hemeprotein cavities: Insights from laser flash photolysis and molecular dynamics simulations, file e27ce42c-8016-2581-e053-d805fe0acbaa 2
A novel small-molecule inhibitor of the human papillomavirus E6-p53 interaction that reactivates p53 function and blocks cancer cells growth, file e27ce42e-f8c9-2581-e053-d805fe0acbaa 2
Structure Activity Relationship of strigolactones via a novel, quantitative in planta bioassay, file e27ce431-9a68-2581-e053-d805fe0acbaa 2
Paracetamol-Galactose Conjugate: A Novel Prodrug for an Old Analgesic Drug, file e27ce434-e75c-2581-e053-d805fe0acbaa 2
Design and synthesis of INF195, a new NLRP3 Inflammasome Inhibitor with ex vivo cardioprotective effect, file 50227747-b902-48df-8dfb-1e81e022782b 1
Strigolactones as Broad-Spectrum Antivirals against β-Coronaviruses through Targeting the Main Protease Mpro, file b53a22d6-3553-46f5-b2b2-2c016099545c 1
Decoding the Structural Basis For Carbapenem Hydrolysis By Class A β-lactamases: Fishing For A Pharmacophore, file e27ce42b-a8cb-2581-e053-d805fe0acbaa 1
A novel Bim-BH3-derived Bcl-XL inhibitor: Biochemical characterization, in vitro, in vivo and ex-vivo anti-leukemic activity, file e27ce42c-5c50-2581-e053-d805fe0acbaa 1
From Experiments to a Fast Easy-to-Use Computational Methodology to Predict Human Aldehyde Oxidase Selectivity and Metabolic Reactions, file e27ce42c-6491-2581-e053-d805fe0acbaa 1
Oxygen and nitric oxide rebinding kinetics in nonsymbiotic hemoglobin AHb1 from Arabidopsis thaliana, file e27ce42c-76d5-2581-e053-d805fe0acbaa 1
Open challenges in structure-based virtual screening: Receptor modeling, target flexibility consideration and active site water molecules description, file e27ce42c-7a67-2581-e053-d805fe0acbaa 1
Totale 4.888
Categoria #
all - tutte 11.136
article - articoli 0
book - libri 0
conference - conferenze 2.867
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 14.003


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/201923 0 0 0 0 0 0 0 0 0 0 0 23
2019/2020541 46 25 17 47 38 31 100 60 57 35 39 46
2020/2021576 39 39 49 24 50 53 94 54 34 53 33 54
2021/2022750 62 39 50 57 62 37 55 55 37 41 169 86
2022/20231.259 17 33 188 175 158 149 106 106 85 80 96 66
2023/20241.442 55 55 66 125 94 110 271 322 60 79 135 70
Totale 4.906