CINECA IRIS Institutional Research Information System

SPYRAKIS, Francesca
 Distribuzione geografica
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Continente #
NA - Nord America 4.161
EU - Europa 2.715
AS - Asia 1.918
AF - Africa 78
SA - Sud America 65
OC - Oceania 40
Continente sconosciuto - Info sul continente non disponibili 2
Totale 8.979
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Nazione #
US - Stati Uniti d'America 4.076
IT - Italia 1.051
CN - Cina 621
SG - Singapore 465
IE - Irlanda 449
FR - Francia 240
SE - Svezia 223
DE - Germania 154
IN - India 148
GB - Regno Unito 92
UA - Ucraina 92
ID - Indonesia 85
VN - Vietnam 85
HK - Hong Kong 83
JP - Giappone 78
PL - Polonia 65
CA - Canada 63
FI - Finlandia 58
KR - Corea 56
TR - Turchia 53
AT - Austria 52
MY - Malesia 45
PK - Pakistan 44
IR - Iran 42
AU - Australia 35
BR - Brasile 34
CH - Svizzera 33
MA - Marocco 33
ES - Italia 32
TW - Taiwan 29
BE - Belgio 25
NL - Olanda 23
PH - Filippine 23
MX - Messico 22
RO - Romania 21
DK - Danimarca 17
RU - Federazione Russa 17
RS - Serbia 15
NO - Norvegia 14
PT - Portogallo 12
TH - Thailandia 12
EG - Egitto 11
CL - Cile 10
NG - Nigeria 10
SA - Arabia Saudita 8
CO - Colombia 7
IL - Israele 7
ZA - Sudafrica 7
AR - Argentina 6
BD - Bangladesh 6
EC - Ecuador 6
GR - Grecia 6
IQ - Iraq 6
SK - Slovacchia (Repubblica Slovacca) 6
TZ - Tanzania 6
NZ - Nuova Zelanda 5
KW - Kuwait 4
SI - Slovenia 4
AM - Armenia 3
CI - Costa d'Avorio 3
CZ - Repubblica Ceca 3
DZ - Algeria 3
AE - Emirati Arabi Uniti 2
AF - Afghanistan, Repubblica islamica di 2
BA - Bosnia-Erzegovina 2
BG - Bulgaria 2
BO - Bolivia 2
EE - Estonia 2
EU - Europa 2
HU - Ungheria 2
KZ - Kazakistan 2
NP - Nepal 2
QA - Qatar 2
YE - Yemen 2
BY - Bielorussia 1
CM - Camerun 1
GH - Ghana 1
LB - Libano 1
LT - Lituania 1
LU - Lussemburgo 1
MO - Macao, regione amministrativa speciale della Cina 1
SC - Seychelles 1
TN - Tunisia 1
UZ - Uzbekistan 1
ZW - Zimbabwe 1
Totale 8.979
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Città #
Chandler 476
Dublin 446
Singapore 390
Santa Clara 295
Beijing 245
Fairfield 234
Torino 198
Turin 184
Houston 170
Ashburn 161
Villeurbanne 158
Nyköping 142
Columbus 120
Los Angeles 120
Woodbridge 119
Wilmington 112
Princeton 100
Seattle 97
Cambridge 82
Medford 77
Ann Arbor 75
Jakarta 74
Pisa 69
Redwood City 66
Boston 59
Dong Ket 50
Jacksonville 49
Boardman 44
Warsaw 44
Vienna 42
Dearborn 41
Subang Jaya 37
Zola Predosa 36
Hong Kong 35
Hangzhou 33
San Diego 31
Milan 28
Shanghai 27
Norwalk 26
Lappeenranta 25
Nanjing 25
Rome 23
Helsinki 22
Istanbul 22
New Delhi 21
Washington 21
Ottawa 20
Tokyo 20
Parma 19
Nuremberg 18
Toronto 17
Bengaluru 16
Guangzhou 16
Brisbane 15
Brussels 15
Central 15
Gongju 15
Seoul 15
London 14
New York 14
Paris 14
Chennai 13
Perugia 13
San Mauro Torinese 13
Buffalo 12
Frankfurt am Main 12
Hefei 12
Kunming 12
Modena 12
Taipei 12
Karachi 11
Pune 11
Rivoli 11
Bari 10
Belgrade 10
Braunschweig 10
Guiyang 10
Madrid 10
Munich 10
Wuhan 10
Birmingham 9
Casteggio 9
Geneva 9
Hebei 9
Zurich 9
Alessandria 8
Baltimore 8
Boffalora sopra Ticino 8
Hyderabad 8
Tübingen 8
Bangkok 7
Barcelona 7
Casablanca 7
Changsha 7
Chengdu 7
Copenhagen 7
Faisalabad 7
Fremont 7
Kahramanmaraş 7
Krakow 7
Totale 5.563
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Nome #
Essential oils bearing specialized metabolites with potential hypoglycemic activity: a bio-guided fractionation approach driven by in vitro (porcine, human and fungal) α-amylase inhibition assays 447
Human dopamine transporter: the first implementation of a combined in silico/in vitro approach revealing the substrate and inhibitor specificities 383
In the search for new NLRP3 inhibitors: chemical modulation of the 1-(piperidin-4-yl)-1,3-dihydro-2 Hbenzo[d]imidazole-2-one scaffold 310
Comparing Drug Images and Repurposing Drugs with BioGPS and FLAPdock: The Thymidylate Synthase Case 270
The Roles of Water in the Protein Matrix: A Largely Untapped Resource for Drug Discovery 186
Multiple catalytic activities of human 17β-hydroxysteroid dehydrogenase type 7 respond differently to inhibitors. 183
Recent advances in the synthesis of analogues of phytohormones strigolactones with ring-closing metathesis as a key step 164
A Pipeline to Enhance Ligand Virtual Screening: Integrating Molecular Dynamics and Fingerprints for Ligand and Proteins 157
Structure Activity Relationship of strigolactones via a novel, quantitative in planta bioassay 156
New aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the hydroxytriazole scaffold 156
Long period fiber grating working in reflection mode as valuable biosensing platform for the detection of drug resistant bacteria 144
Strigolactones as antiviral drugs to inhibit Herpesvirus replication 138
Strigolactone analogs are promising antiviral agents against Herpesviruses 137
Paracetamol-Galactose Conjugate: A Novel Prodrug for an Old Analgesic Drug 134
Fluorescent Nitric Oxide Photodonors Based on BODIPY and Rhodamine Antennae 132
Evaluation of Porcine and Aspergillus oryzae α-Amylases as Possible Model for the Human Enzyme 129
CO Rebinding Kinetics and Molecular Dynamics Simulations Highlight Dynamic Regulation of Internal Cavities in Human Cytoglobin 126
Targeting cystalysin, a virulence factor of Treponema denticola-supported periodontitis 126
A new approach for investigating protein flexibility based on Constraint Logic Programming. The first application in the case of the estrogen receptor 124
4-amino-1,2,4-triazole-3-thione as a promising scaffold for the inhibition of serine and metallo-β-lactamases 123
New inhibitors of Aldo-Keto Reductase 1C3 (AKR1C3) based on benzoisoxazole scaffold and their potential application in cancer 123
Virtual screening identifies broad-spectrum β-lactamase inhibitors with activity on clinically relevant serine- and metallo-carbapenemases 120
Ligand migration through hemeprotein cavities: Insights from laser flash photolysis and molecular dynamics simulations 118
Tuning the Hydrophobicity of a Mitochondria-Targeted NO Photodonor 116
Chemical modulation of the 1-(Piperidin-4-yl)-1,3-dihydro-2h-benzo[d]imidazole-2-one scaffold as a novel NLRP3 inhibitor 107
Iron metabolism at the interface between host and pathogen: From nutritional immunity to antibacterial development 104
DNA-targeted NO release photoregulated by green light 99
Interaction of human hemoglobin and semi-hemoglobins with the Staphylococcus aureus hemophore IsdB: a kinetic and mechanistic insight 96
New Hydroxybenzoazole Inhibitors of Aldo-Keto Reductase 1C3 (AKR1C3): Disclosure of SAR Investigation to Target Prostate Cancer 95
Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-beta-lactamases 95
Strigolactones as broad-spectrum antivirals against β-coronaviruses through targeting the main protease Mpro 91
Strigolactone Analogs Are Promising Antiviral Agents for the Treatment of Human Cytomegalovirus Infection. 90
Pyridoxal 5-phosphate-dependent enzymes: Catalysis, conformation, and genomics 83
Can we exploit β-lactamases intrinsic dynamics for designing more effective inhibitors? 82
Comparative analysis of inner cavities and ligand migration in non-symbiotic AHb1 and AHb2 81
Bound water at protein-protein interfaces: Partners, roles and hydrophobic bubbles as a conserved motif 77
A community effort in SARS-CoV-2 drug discovery 74
Decoding the Structural Basis For Carbapenem Hydrolysis By Class A β-lactamases: Fishing For A Pharmacophore 74
Isozyme-Specific Ligands for O-acetylserine sulfhydrylase, a Novel Antibiotic Target 74
Multiple-targeting ligands for AKR1C3 enzyme and androgen receptor to target prostate cancer 73
From Experiments to a Fast Easy-to-Use Computational Methodology to Predict Human Aldehyde Oxidase Selectivity and Metabolic Reactions 71
Chemogenomics of pyridoxal 5′-phosphate dependent enzymes 69
Strigolactones as broad-spectrum antivirals against ß-coronaviruses through targeting the main protease Mpro 67
A Blueprint for High Affinity SARS-CoV-2 Mpro Inhibitors from Activity-Based Compound Library Screening Guided by Analysis of Protein Dynamics 62
Strigolactone analogs are promising antiviral agents for the treatment of human cytomegalovirus infection 62
Structural insight into the interaction of O-acetylserine sulfhydrylase with competitive, peptidic inhibitors by saturation transfer difference-NMR 60
BROAD SPECTRUM METALLO beta-LACTAMASES INHIBITORS: NEW TOOLS AGAINST CLINICALLY-RELEVANT CARBAPENEMASES 59
Binding of androgen-and estrogen-like flavonoids to their cognate (Non)nuclear receptors: A comparison by computational prediction 59
Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAFV600E Protein 58
Fine tuning of the active site modulates specificity in the interaction of O-acetylserine sulfhydrylase isozymes with serine acetyltransferase 58
Allosteric communication between alpha and beta subunits of tryptophan synthase: Modelling the open-closed transition of the alpha subunit 58
BioGPS: The music for the chemo- and bioinformatics walzer 58
Open challenges in structure-based virtual screening: Receptor modeling, target flexibility consideration and active site water molecules description 57
Comparative mapping of on-targets and off-targets for the discovery of anti-trypanosomatid folate pathway inhibitors 56
First virtual screening and experimental validation of inhibitors targeting GES-5 carbapenemase 56
Strigolactone Analogs Are Promising Antiviral Agents for the Treatment of Human Cytomegalovirus Infection 56
Complexity in modeling and understanding protonation states: Computational titration of HIV-1-protease-inhibitor complexes 55
Indomethacin Inhibits Proliferation In Cells Harbouring PIK3CA Mutations 55
Strigolactones as broad-spectrum antivirals against β-coronaviruses through targeting SARS-CoV-2 Mpro 54
Computational titration analysis of a multiprotic HIV-1 protease-ligand complex 54
Ten Years with New Delhi Metallo-β-lactamase-1 (NDM-1): From Structural Insights to Inhibitor Design 54
Correct protonation states and relevant waters = better computational simulations? 53
Label-free fiber optic optrode for the detection of class C beta-lactamases expressed by drug resistant bacteria 53
Discovery of a novel 1,3,4-oxadiazol-2-one-based NLRP3 inhibitor as a pharmacological agent to mitigate cardiac and metabolic complications in an experimental model of diet-induced metaflammation 52
Lack of interaction of the fluorosurfactant C6O4 with human renal transporters: In vitro/in silico analysis 51
The consequences of scoring docked ligand conformations using free energy correlations 51
Discovering New Casein Kinase 1d Inhibitors with an Innovative Molecular Dynamics Enabled Virtual Screening Workflow 51
The allosteric interplay between S-nitrosylation and glycine binding controls the activity of human serine racemase 51
Oxygen and nitric oxide rebinding kinetics in nonsymbiotic hemoglobin AHb1 from Arabidopsis thaliana 49
A generator of peroxynitrite activatable with red light 49
Novel peptide-conjugated nanomedicines for brain targeting: In vivo evidence 48
FADB: A food additive molecular database for in silico screening in food toxicology 47
Energy-based prediction of amino acid-nucleotide base recognition 47
A novel small-molecule inhibitor of the human papillomavirus E6-p53 interaction that reactivates p53 function and blocks cancer cells growth 46
Exploring Ligand Binding Domain Dynamics in the NRs Superfamily 44
Structure-based virtual screening for the discovery of novel inhibitors of New Delhi Metallo-beta-lactamase-1 44
Different roles of protein dynamics and ligand migration in non-symbiotic hemoglobins AHb1 and AHb2 from Arabidopsis thaliana 44
Rational design of a user-friendly aptamer/peptide-based device for the detection of staphylococcus aureus 44
Repurposing the trypanosomatidic gsk kinetobox for the inhibition of parasitic pteridine and dihydrofolate reductases 44
Cryo-EM structures of staphylococcal IsdB bound to human hemoglobin reveal the process of heme extraction 43
Application of an in house bioisosteric approach to the design of innovative inhibitors of aldo-keto reductase 1C3 (AKR1C3) 42
The inhibition of extended spectrum β-lactamases: Hits and leads 42
A novel Bim-BH3-derived Bcl-XL inhibitor: Biochemical characterization, in vitro, in vivo and ex-vivo anti-leukemic activity 41
Structural plasticity and functional implications of internal cavities in distal mutants of type 1 non-symbiotic hemoglobin AHb1 from Arabidopsis thaliana 41
Theoretical calculations of the catalytic triad in short-chain alcohol dehydrogenases/reductases 41
A structural homologue of the plant receptor D14 mediates responses to strigolactones in the fungal phytopathogen Cryphonectria parasitica 41
Strigolactones, from Plants to Human Health: Achievements and Challenges 40
Design of O-acetylserine sulfhydrylase inhibitors by mimicking nature 38
N-[1,3-Dialkyl(aryl)-2-oxoimidazolidin-4-ylidene]-aryl(alkyl)sulphonamides as Novel Selective Human Cannabinoid Type 2 Receptor (hCB2R) Ligands; Insights into the Mechanism of Receptor Activation/Deactivation 37
HYDROXYLATED HETEROCYCLES AS BIOISOSTERES OF THE CARBOXYLIC FUNCTION: DESIGN OF NEW AKR1C3 INHIBITORS ACTIVE IN PROSTATE CANCER 37
How computational methods try to disclose the estrogen receptor secrecy - Modeling the flexibility 37
PROTAC-Induced Glycogen Synthase Kinase 3β Degradation as a Potential Therapeutic Strategy for Alzheimer's Disease 35
Selective delivery of pentamidine toward cancer cells by self-assembled nanoparticles 35
A new generation of AKR1C3 inhibitors on the horizon: the 3- hydroxybenzazole approach to target prostate cancer 35
Energetics of the protein-DNA-water interaction 35
NO release regulated by doxorubicin as the green light-harvesting antenna 35
Design and synthesis of INF195, a new NLRP3 Inflammasome Inhibitor with ex vivo cardioprotective effect 34
Strigolactones as Broad-Spectrum Antivirals against β-Coronaviruses through Targeting the Main Protease Mpro 33
Editorial: Thematic issue: From extended spectrum β-lactamases to carbapenemase: The never ending challenge against gram-negative bacteria 33
Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer 32
Totale 8.490
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Categoria #
all - tutte 34.204
article - articoli 0
book - libri 0
conference - conferenze 6.349
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 40.553
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020449 0 0 0 0 0 0 106 81 79 81 57 45
2020/2021893 50 55 62 36 87 79 127 48 102 68 51 128
2021/20221.053 44 56 72 61 59 35 60 54 40 77 272 223
2022/20231.993 134 155 58 192 168 501 179 132 202 66 95 111
2023/20241.664 136 162 125 106 121 135 200 146 29 130 146 228
2024/20251.654 108 272 216 312 498 220 28 0 0 0 0 0
Totale 9.389