CINECA IRIS Institutional Research Information System

SPYRAKIS, Francesca
 Distribuzione geografica
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Continente #
NA - Nord America 3.492
EU - Europa 2.514
AS - Asia 1.366
SA - Sud America 62
AF - Africa 57
OC - Oceania 35
Continente sconosciuto - Info sul continente non disponibili 2
Totale 7.528
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Nazione #
US - Stati Uniti d'America 3.418
IT - Italia 975
CN - Cina 517
IE - Irlanda 449
FR - Francia 235
SE - Svezia 222
SG - Singapore 200
IN - India 128
DE - Germania 122
UA - Ucraina 90
VN - Vietnam 85
GB - Regno Unito 83
HK - Hong Kong 74
JP - Giappone 74
CA - Canada 58
KR - Corea 52
PL - Polonia 50
FI - Finlandia 46
TR - Turchia 46
MY - Malesia 43
AT - Austria 39
AU - Australia 34
BR - Brasile 33
PK - Pakistan 32
IR - Iran 27
ES - Italia 26
TW - Taiwan 25
BE - Belgio 21
CH - Svizzera 21
MA - Marocco 21
NL - Olanda 19
RO - Romania 18
DK - Danimarca 17
MX - Messico 16
ID - Indonesia 15
RU - Federazione Russa 15
NO - Norvegia 14
RS - Serbia 13
PT - Portogallo 11
TH - Thailandia 11
CL - Cile 10
NG - Nigeria 9
CO - Colombia 7
ZA - Sudafrica 7
AR - Argentina 6
IL - Israele 6
SK - Slovacchia (Repubblica Slovacca) 6
TZ - Tanzania 6
EG - Egitto 5
GR - Grecia 5
PH - Filippine 5
EC - Ecuador 4
KW - Kuwait 4
SI - Slovenia 4
AM - Armenia 3
CI - Costa d'Avorio 3
CZ - Repubblica Ceca 3
DZ - Algeria 3
IQ - Iraq 3
SA - Arabia Saudita 3
AE - Emirati Arabi Uniti 2
AF - Afghanistan, Repubblica islamica di 2
BA - Bosnia-Erzegovina 2
BG - Bulgaria 2
BO - Bolivia 2
EE - Estonia 2
EU - Europa 2
HU - Ungheria 2
NP - Nepal 2
QA - Qatar 2
YE - Yemen 2
BY - Bielorussia 1
CM - Camerun 1
GH - Ghana 1
LB - Libano 1
LU - Lussemburgo 1
MO - Macao, regione amministrativa speciale della Cina 1
NZ - Nuova Zelanda 1
SC - Seychelles 1
UZ - Uzbekistan 1
Totale 7.528
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Città #
Chandler 476
Dublin 446
Beijing 243
Fairfield 234
Torino 198
Houston 170
Turin 158
Villeurbanne 158
Ashburn 155
Nyköping 142
Singapore 142
Los Angeles 118
Woodbridge 118
Wilmington 112
Princeton 100
Seattle 96
Cambridge 80
Medford 77
Ann Arbor 75
Pisa 69
Redwood City 66
Boston 59
Dong Ket 50
Jacksonville 49
Boardman 44
Dearborn 41
Warsaw 38
Subang Jaya 37
Vienna 36
Zola Predosa 36
Hangzhou 33
San Diego 31
Hong Kong 30
Milan 27
Norwalk 26
Nanjing 25
Shanghai 24
Helsinki 21
Washington 21
Istanbul 20
Ottawa 20
New Delhi 19
Rome 19
Santa Clara 18
Parma 17
Tokyo 17
Guangzhou 16
Toronto 16
Brisbane 15
Central 15
Gongju 15
Lappeenranta 15
Seoul 15
Bengaluru 14
Brussels 13
New York 13
Paris 13
San Mauro Torinese 13
Buffalo 12
Chennai 12
Hefei 12
Kunming 12
Modena 12
Karachi 11
London 11
Perugia 11
Braunschweig 10
Taipei 10
Wuhan 10
Bari 9
Birmingham 9
Casteggio 9
Hebei 9
Pune 9
Rivoli 9
Alessandria 8
Belgrade 8
Boffalora sopra Ticino 8
Bangkok 7
Barcelona 7
Changsha 7
Chengdu 7
Copenhagen 7
Fremont 7
Kahramanmaraş 7
Madrid 7
Santiago 7
Shenyang 7
Shiraz 7
Tromsø 7
Tübingen 7
Vercelli 7
Zurich 7
Abuja 6
Avigliana 6
Balotesti 6
Bethesda 6
Bradford 6
Chandigarh 6
Fes 6
Totale 4.712
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Nome #
Human dopamine transporter: the first implementation of a combined in silico/in vitro approach revealing the substrate and inhibitor specificities 366
Essential oils bearing specialized metabolites with potential hypoglycemic activity: a bio-guided fractionation approach driven by in vitro (porcine, human and fungal) α-amylase inhibition assays 298
Comparing Drug Images and Repurposing Drugs with BioGPS and FLAPdock: The Thymidylate Synthase Case 267
In the search for new NLRP3 inhibitors: chemical modulation of the 1-(piperidin-4-yl)-1,3-dihydro-2 Hbenzo[d]imidazole-2-one scaffold 250
The Roles of Water in the Protein Matrix: A Largely Untapped Resource for Drug Discovery 175
Multiple catalytic activities of human 17β-hydroxysteroid dehydrogenase type 7 respond differently to inhibitors. 165
Recent advances in the synthesis of analogues of phytohormones strigolactones with ring-closing metathesis as a key step 151
A Pipeline to Enhance Ligand Virtual Screening: Integrating Molecular Dynamics and Fingerprints for Ligand and Proteins 145
Structure Activity Relationship of strigolactones via a novel, quantitative in planta bioassay 141
Long period fiber grating working in reflection mode as valuable biosensing platform for the detection of drug resistant bacteria 136
Strigolactones as antiviral drugs to inhibit Herpesvirus replication 129
New aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the hydroxytriazole scaffold 129
Strigolactone analogs are promising antiviral agents against Herpesviruses 126
Targeting cystalysin, a virulence factor of Treponema denticola-supported periodontitis 123
CO Rebinding Kinetics and Molecular Dynamics Simulations Highlight Dynamic Regulation of Internal Cavities in Human Cytoglobin 119
Fluorescent Nitric Oxide Photodonors Based on BODIPY and Rhodamine Antennae 119
Ligand migration through hemeprotein cavities: Insights from laser flash photolysis and molecular dynamics simulations 114
New inhibitors of Aldo-Keto Reductase 1C3 (AKR1C3) based on benzoisoxazole scaffold and their potential application in cancer 112
A new approach for investigating protein flexibility based on Constraint Logic Programming. The first application in the case of the estrogen receptor 109
Virtual screening identifies broad-spectrum β-lactamase inhibitors with activity on clinically relevant serine- and metallo-carbapenemases 109
4-amino-1,2,4-triazole-3-thione as a promising scaffold for the inhibition of serine and metallo-β-lactamases 108
Evaluation of Porcine and Aspergillus oryzae α-Amylases as Possible Model for the Human Enzyme 108
Paracetamol-Galactose Conjugate: A Novel Prodrug for an Old Analgesic Drug 98
Tuning the Hydrophobicity of a Mitochondria-Targeted NO Photodonor 96
Chemical modulation of the 1-(Piperidin-4-yl)-1,3-dihydro-2h-benzo[d]imidazole-2-one scaffold as a novel NLRP3 inhibitor 92
DNA-targeted NO release photoregulated by green light 90
Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-beta-lactamases 88
Iron metabolism at the interface between host and pathogen: From nutritional immunity to antibacterial development 86
Interaction of human hemoglobin and semi-hemoglobins with the Staphylococcus aureus hemophore IsdB: a kinetic and mechanistic insight 85
New Hydroxybenzoazole Inhibitors of Aldo-Keto Reductase 1C3 (AKR1C3): Disclosure of SAR Investigation to Target Prostate Cancer 83
Strigolactone Analogs Are Promising Antiviral Agents for the Treatment of Human Cytomegalovirus Infection. 83
Pyridoxal 5-phosphate-dependent enzymes: Catalysis, conformation, and genomics 81
Comparative analysis of inner cavities and ligand migration in non-symbiotic AHb1 and AHb2 73
Decoding the Structural Basis For Carbapenem Hydrolysis By Class A β-lactamases: Fishing For A Pharmacophore 72
Strigolactones as broad-spectrum antivirals against β-coronaviruses through targeting the main protease Mpro 70
Bound water at protein-protein interfaces: Partners, roles and hydrophobic bubbles as a conserved motif 69
Chemogenomics of pyridoxal 5′-phosphate dependent enzymes 66
Can we exploit β-lactamases intrinsic dynamics for designing more effective inhibitors? 64
Isozyme-Specific Ligands for O-acetylserine sulfhydrylase, a Novel Antibiotic Target 60
From Experiments to a Fast Easy-to-Use Computational Methodology to Predict Human Aldehyde Oxidase Selectivity and Metabolic Reactions 58
Structural insight into the interaction of O-acetylserine sulfhydrylase with competitive, peptidic inhibitors by saturation transfer difference-NMR 56
Multiple-targeting ligands for AKR1C3 enzyme and androgen receptor to target prostate cancer 56
Open challenges in structure-based virtual screening: Receptor modeling, target flexibility consideration and active site water molecules description 54
Comparative mapping of on-targets and off-targets for the discovery of anti-trypanosomatid folate pathway inhibitors 54
A Blueprint for High Affinity SARS-CoV-2 Mpro Inhibitors from Activity-Based Compound Library Screening Guided by Analysis of Protein Dynamics 54
Complexity in modeling and understanding protonation states: Computational titration of HIV-1-protease-inhibitor complexes 53
Strigolactones as broad-spectrum antivirals against ß-coronaviruses through targeting the main protease Mpro 51
Correct protonation states and relevant waters = better computational simulations? 51
Computational titration analysis of a multiprotic HIV-1 protease-ligand complex 51
BioGPS: The music for the chemo- and bioinformatics walzer 51
Strigolactone analogs are promising antiviral agents for the treatment of human cytomegalovirus infection 51
Fine tuning of the active site modulates specificity in the interaction of O-acetylserine sulfhydrylase isozymes with serine acetyltransferase 50
The consequences of scoring docked ligand conformations using free energy correlations 49
Label-free fiber optic optrode for the detection of class C beta-lactamases expressed by drug resistant bacteria 49
Allosteric communication between alpha and beta subunits of tryptophan synthase: Modelling the open-closed transition of the alpha subunit 48
Ten Years with New Delhi Metallo-β-lactamase-1 (NDM-1): From Structural Insights to Inhibitor Design 48
First virtual screening and experimental validation of inhibitors targeting GES-5 carbapenemase 47
Strigolactones as broad-spectrum antivirals against β-coronaviruses through targeting SARS-CoV-2 Mpro 46
Strigolactone Analogs Are Promising Antiviral Agents for the Treatment of Human Cytomegalovirus Infection 46
A community effort in SARS-CoV-2 drug discovery 45
FADB: A food additive molecular database for in silico screening in food toxicology 45
Indomethacin Inhibits Proliferation In Cells Harbouring PIK3CA Mutations 45
Discovering New Casein Kinase 1d Inhibitors with an Innovative Molecular Dynamics Enabled Virtual Screening Workflow 45
BROAD SPECTRUM METALLO beta-LACTAMASES INHIBITORS: NEW TOOLS AGAINST CLINICALLY-RELEVANT CARBAPENEMASES 44
Binding of androgen-and estrogen-like flavonoids to their cognate (Non)nuclear receptors: A comparison by computational prediction 44
The allosteric interplay between S-nitrosylation and glycine binding controls the activity of human serine racemase 43
Different roles of protein dynamics and ligand migration in non-symbiotic hemoglobins AHb1 and AHb2 from Arabidopsis thaliana 41
Discovery of a novel 1,3,4-oxadiazol-2-one-based NLRP3 inhibitor as a pharmacological agent to mitigate cardiac and metabolic complications in an experimental model of diet-induced metaflammation 40
Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAFV600E Protein 40
Structure-based virtual screening for the discovery of novel inhibitors of New Delhi Metallo-beta-lactamase-1 40
A novel small-molecule inhibitor of the human papillomavirus E6-p53 interaction that reactivates p53 function and blocks cancer cells growth 40
The inhibition of extended spectrum β-lactamases: Hits and leads 39
Rational design of a user-friendly aptamer/peptide-based device for the detection of staphylococcus aureus 39
Novel peptide-conjugated nanomedicines for brain targeting: In vivo evidence 39
Oxygen and nitric oxide rebinding kinetics in nonsymbiotic hemoglobin AHb1 from Arabidopsis thaliana 38
Theoretical calculations of the catalytic triad in short-chain alcohol dehydrogenases/reductases 37
Design of O-acetylserine sulfhydrylase inhibitors by mimicking nature 36
A generator of peroxynitrite activatable with red light 36
How computational methods try to disclose the estrogen receptor secrecy - Modeling the flexibility 35
Application of an in house bioisosteric approach to the design of innovative inhibitors of aldo-keto reductase 1C3 (AKR1C3) 34
Lack of interaction of the fluorosurfactant C6O4 with human renal transporters: In vitro/in silico analysis 34
Energy-based prediction of amino acid-nucleotide base recognition 34
A novel Bim-BH3-derived Bcl-XL inhibitor: Biochemical characterization, in vitro, in vivo and ex-vivo anti-leukemic activity 33
Energetics of the protein-DNA-water interaction 32
A structural homologue of the plant receptor D14 mediates responses to strigolactones in the fungal phytopathogen Cryphonectria parasitica 32
Cryo-EM structures of staphylococcal IsdB bound to human hemoglobin reveal the process of heme extraction 31
Exploring Ligand Binding Domain Dynamics in the NRs Superfamily 31
Editorial: Thematic issue: From extended spectrum β-lactamases to carbapenemase: The never ending challenge against gram-negative bacteria 31
Strigolactones, from Plants to Human Health: Achievements and Challenges 30
Structural plasticity and functional implications of internal cavities in distal mutants of type 1 non-symbiotic hemoglobin AHb1 from Arabidopsis thaliana 29
Repurposing the trypanosomatidic gsk kinetobox for the inhibition of parasitic pteridine and dihydrofolate reductases 29
HYDROXYLATED HETEROCYCLES AS BIOISOSTERES OF THE CARBOXYLIC FUNCTION: DESIGN OF NEW AKR1C3 INHIBITORS ACTIVE IN PROSTATE CANCER 28
Serine racemase: A key player in neuron activity and in neuropathologies 28
Editorial [Hot topic: Applying Induced Fit in Drug Discovery: Square Pegs and Round Holes? (Guest Editors: Francesca Spyrakis, Pietro Cozzini, Aurijit Sarkar and Glen E. Kellogg)] 27
Ligand migration and hexacoordination in type 1 non-symbiotic rice hemoglobin 27
Robust classification of "relevant" water molecules in putative protein binding sites 26
NO release regulated by doxorubicin as the green light-harvesting antenna 26
N-[1,3-Dialkyl(aryl)-2-oxoimidazolidin-4-ylidene]-aryl(alkyl)sulphonamides as Novel Selective Human Cannabinoid Type 2 Receptor (hCB2R) Ligands; Insights into the Mechanism of Receptor Activation/Deactivation 25
Target flexibility: An emerging consideration in drug discovery and design 25
The reactivity with CO of AHb1 and AHb2 from Arabidopsis thaliana is controlled by the distal HisE7 and internal hydrophobic cavities 25
Totale 7.306
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Categoria #
all - tutte 27.296
article - articoli 0
book - libri 0
conference - conferenze 4.848
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 32.144
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020749 0 25 23 127 40 85 106 81 79 81 57 45
2020/2021893 50 55 62 36 87 79 127 48 102 68 51 128
2021/20221.053 44 56 72 61 59 35 60 54 40 77 272 223
2022/20231.993 134 155 58 192 168 501 179 132 202 66 95 111
2023/20241.664 136 162 125 106 121 135 200 146 29 130 146 228
2024/2025200 108 92 0 0 0 0 0 0 0 0 0 0
Totale 7.935