Oxysterols greatly interfere with the human digestive tract homeostasis, by promoting the damage of the colonic epithelial layer through NOX1 activation. Pretreatment of oxysterol-challenged cells with Cannonau extract, in amount corresponding to one glass (100 ml) of wine, or with its major polyphenol compounds, diminished NOX1 activity and ROS generation.

Polyphenols from Sardinian red wine can modulate NOX1-dependent reactive oxygen species production in human enterocyte-like cells treated with a dietary mixture of oxysterols

MAINA, MARCO;POLI, Giuseppe;BIASI, Fiorella
2012

Abstract

Oxysterols greatly interfere with the human digestive tract homeostasis, by promoting the damage of the colonic epithelial layer through NOX1 activation. Pretreatment of oxysterol-challenged cells with Cannonau extract, in amount corresponding to one glass (100 ml) of wine, or with its major polyphenol compounds, diminished NOX1 activity and ROS generation.
Society for Free Radical Research International, 16th Biennial Meeting
London
6-9 settembre 2012
53
suppl 1
193
194
FREE RADICAL BIOLOGY & MEDICINE
http://www.journals.elsevier.com/free-radical-biology-and-medicine/
polyphenols; oxysterols; NADPH oxidase; CaCo-2 cells
Cabboi B; Deiana M; Maina M; Poli G; Dessì MA; Biasi F
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/103797
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