Oxysterols greatly interfere with the human digestive tract homeostasis, by promoting the damage of the colonic epithelial layer through NOX1 activation. Pretreatment of oxysterol-challenged cells with Cannonau extract, in amount corresponding to one glass (100 ml) of wine, or with its major polyphenol compounds, diminished NOX1 activity and ROS generation.
Polyphenols from Sardinian red wine can modulate NOX1-dependent reactive oxygen species production in human enterocyte-like cells treated with a dietary mixture of oxysterols
MAINA, MARCO;POLI, Giuseppe;BIASI, Fiorella
2012-01-01
Abstract
Oxysterols greatly interfere with the human digestive tract homeostasis, by promoting the damage of the colonic epithelial layer through NOX1 activation. Pretreatment of oxysterol-challenged cells with Cannonau extract, in amount corresponding to one glass (100 ml) of wine, or with its major polyphenol compounds, diminished NOX1 activity and ROS generation.
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