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Semaphorin3A induces fibroblast polarization towards an antitumor phenotype in pancreatic ductal adenocarcinoma

Background and Aims Pancreatic Ductal Adenocarcinoma (PDAC) is a deadly and challenging disease due to its hostile, fibrotic and immunosuppressed tumor microenvironment (TME) that lessens the efficacy of current treatment options. Therefore, there is a strong need to develop novel therapeutic strategies that efficiently target the TME to hamper PDAC progression. Methods Single cell RNA-sequencing analysis was performed after purifying the TME from PDAC mouse models treated with a mutated ...

Semaphorin 4A-expressing bone marrow-derived myeloid cells promote tumor progression

Background and aims Semaphorins (Semas) and Plexins are a family of proteins involved in the regulation of the tumor microenvironment and cancer growth. We previously described that Sema4A, overexpressed in myeloid cells under inflammatory conditions, exerted a pro-angiogenic effect. In this study, we investigated the role of Sema4A and its receptor in tumor-associated inflammation and cancer progression. Methods We silenced Sema4A in bone marrow-derived myeloid cells (BMCs), by means of...

Inhibition of Semaphorin 4A-expressing bone marrow-derived myeloid cells impairs tumor progression in PDAC

Semaphorins (Semas) and Plexins belong to a large protein family of axon guidance cues involved in the regulation of tumor progression, metastasis spreading and tumor microenvironment (TME). Among these, Sema4A is critically involved in the regulation of the immune response, but its role in cancer progression is still unclear. In the present study, we investigated the role of Sema4A and its receptors in the progression of pancreatic ductal adenocarcinoma (PDAC). Herein we showed that Sema4A...

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Tipologia
  • 04-CONTRIBUTO IN ATTI DI CONVEGNO42813
  • 02-CAPITOLO DI LIBRO1
Autore
  • BALSARI, Paolo457
  • ALMA, Alberto307
  • COCOLIN, Luca Simone289
  • PORTIS, Ezio289
  • LANTERI, Sergio283
  • BAROLO, Claudia275
  • BICCHI, Carlo269
  • ROLLE, Luca Giorgio Carlo251
  • BLANDINO, Massimo249
  • CATTEL, Luigi248
Data di pubblicazione
  • In corso di stampa47
  • 2020 - 20265850
  • 2010 - 201917460
  • 2000 - 200915290
  • 1990 - 19993135
  • 1980 - 1989902
  • 1970 - 1979125
  • 1966 - 19694
Editore
  • -2078
  • IEEE565
  • Springer532
  • ACM245
  • Società Chimica Italiana190
  • --181
  • CEUR-WS175
  • Institute of Electrical and Elect...146
  • IEEE Computer Society135
  • Springer-Verlag130
Rivista
  • BLOOD289
  • HAEMATOLOGICA191
  • GIORNALE ITALIANO DI PSICOPATOLOGIA149
  • POS PROCEEDINGS OF SCIENCE128
  • JOURNAL OF HEPATOLOGY124
  • DIGESTIVE AND LIVER DISEASE121
  • DIABETOLOGIA118
  • EPITOME111
  • SPORT SCIENCES FOR HEALTH106
  • GIORNALE ITALIANO DI MEDICINA DEL...87
Serie
  • LECTURE NOTES IN COMPUTER SCIENCE340
  • CEUR WORKSHOP PROCEEDINGS316
  • LECTURE NOTES IN ARTIFICIAL INTEL...129
  • EUROMED ACADEMY OF BUSINESS CONFE...34
  • COMMUNICATIONS IN COMPUTER AND IN...28
  • LECTURE NOTES IN COMPUTER SCIENCE28
  • LEIBNIZ INTERNATIONAL PROCEEDINGS...22
  • LECTURE NOTES IN CIVIL ENGINEERING21
  • AIP CONFERENCE PROCEEDINGS19
  • ACTA ITALUS HORTUS16
Keyword
  • Piemonte73
  • Artificial Intelligence65
  • Computer Science (all)57
  • Software54
  • Computer Networks and Communications45
  • liver transplantation42
  • dog39
  • Italy38
  • sustainability37
  • social media36
Lingua
  • eng30033
  • ita12033
  • fre476
  • spa209
  • rus55
  • por48
  • Inglese44
  • ger42
  • Italiano42
  • und24
Accesso al fulltext
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  • reserved4584
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  • embargoed20
  • mixed3
  • restricted3