A novel tryptophyllin has been isolated from the methanol extracts of the skin of the South American frog Phyllomedusa rohdei. Its primary structure, as determined by chemical/enzymatic methods and by FAB mass spectrometry, is the following: Lys-Pro-Hyp-Ser-Trp-Ile-Pro-NH2. This basic tryptophyllin has been synthesized in solid phase, in order to allow its complete pharmacological characterization.

Isolation, Structure Determination and Synthesis of a Novel Tryptophan-Containing Heptapeptide (Basic Tryptophyllin) from the Skin of Phyllomedusa Rohdei

VINCENTI, Marco;
1989-01-01

Abstract

A novel tryptophyllin has been isolated from the methanol extracts of the skin of the South American frog Phyllomedusa rohdei. Its primary structure, as determined by chemical/enzymatic methods and by FAB mass spectrometry, is the following: Lys-Pro-Hyp-Ser-Trp-Ile-Pro-NH2. This basic tryptophyllin has been synthesized in solid phase, in order to allow its complete pharmacological characterization.
1989
33
391
395
http://onlinelibrary.wiley.com/doi/10.1111/j.1399-3011.1989.tb00700.x/abstract
automatic Edman degradation,FAB,frog skin,gas-phase sequencer,trans-4-hydroxyproline,mass spectrometry,PTH Hyp,Phyllomedusa rohdei,solid-phase peptide synthesis,tryptophyllins
P.C. Montecucchi; M. Vincenti; A.M. Lazzarini; L. Rusconi; V. Erspamer
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/105122
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