A novel tryptophyllin has been isolated from the methanol extracts of the skin of the South American frog Phyllomedusa rohdei. Its primary structure, as determined by chemical/enzymatic methods and by FAB mass spectrometry, is the following: Lys-Pro-Hyp-Ser-Trp-Ile-Pro-NH2. This basic tryptophyllin has been synthesized in solid phase, in order to allow its complete pharmacological characterization.
Isolation, Structure Determination and Synthesis of a Novel Tryptophan-Containing Heptapeptide (Basic Tryptophyllin) from the Skin of Phyllomedusa Rohdei
VINCENTI, Marco;
1989-01-01
Abstract
A novel tryptophyllin has been isolated from the methanol extracts of the skin of the South American frog Phyllomedusa rohdei. Its primary structure, as determined by chemical/enzymatic methods and by FAB mass spectrometry, is the following: Lys-Pro-Hyp-Ser-Trp-Ile-Pro-NH2. This basic tryptophyllin has been synthesized in solid phase, in order to allow its complete pharmacological characterization.File in questo prodotto:
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