α-Ketoacids can be easily synthesized with satisfactory yields and selectivities by carbonylation of arylhalides and secondarybenzylhalides under very mild conditions. The reactions are catalyzed by Co2(CO)8 in alcoholic solvents; the presence of a methyl source (dimethyl sulfate or methyl iodide) is necessary for the carbonylation of the arylhalides. Base, temperature and solvent have large effects on the course of the reaction.
Cobalt-Catalyzed Low Pressure Double Carbonylation of Aryl and Secondary Benzyl Halides
VINCENTI, Marco;
1986-01-01
Abstract
α-Ketoacids can be easily synthesized with satisfactory yields and selectivities by carbonylation of arylhalides and secondarybenzylhalides under very mild conditions. The reactions are catalyzed by Co2(CO)8 in alcoholic solvents; the presence of a methyl source (dimethyl sulfate or methyl iodide) is necessary for the carbonylation of the arylhalides. Base, temperature and solvent have large effects on the course of the reaction.
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