This patent reports a general procedure for the production of N-alkyl-, N,N'-dialkyl-, and N,N,N'-trialkyl-ureas, using O,S-dimethyl dithiocarbonate as a carbonylating reagent for alkylamines. The procedure provides three steps: i) reaction of O,S-dimethyl dithiocarbonate with primary aliphatic amines to give O-methyl N-alkylthiocarbamates; ii) their rearrangement to the corresponding S-methyl N-alkylthiocarbamates; iii) reaction with ammonia or primary or secondary aliphatic amines to give mono-, di-, and tri-substituted ureas. To be noted the complete exploitation of the reagent.

Process for preparing alkylureas from O,S-dimethyl dithiocarbonate

DEGANI, Jacopo;FOCHI, Rita;CADAMURO, Silvano
2004-01-01

Abstract

This patent reports a general procedure for the production of N-alkyl-, N,N'-dialkyl-, and N,N,N'-trialkyl-ureas, using O,S-dimethyl dithiocarbonate as a carbonylating reagent for alkylamines. The procedure provides three steps: i) reaction of O,S-dimethyl dithiocarbonate with primary aliphatic amines to give O-methyl N-alkylthiocarbamates; ii) their rearrangement to the corresponding S-methyl N-alkylthiocarbamates; iii) reaction with ammonia or primary or secondary aliphatic amines to give mono-, di-, and tri-substituted ureas. To be noted the complete exploitation of the reagent.
2004
US 6723875
OXON ITALIA S.p.A., Italy
O; S-dimethyl dithiocarbonate; carbonylation; ureas; thiocarbamates; amines
PALLUCCA E; DEGANI I; SERRI A M; FOCHI R; GAZZETTO S; FENOGLIO C; ORNATI C; MIGLIACCIO M; CARVOLI G; CADAMURO S
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1082
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