The effects of an oral subacute treatment with L-DOPA on L glutamate decarboxylase (GAD), GABA and GABA transaminase (GABA-T) in chick n. basalis (homologous to the mammalian striatum), brain hemispheres, brain stem and retina were studied. A significant increase in n. basalis GAD activity associated with an increase in GABA content and decrease of GABA-T activity was shown to occur. Similar effects were observed in the brain stem except for GABA-T which was stimulated. In contrast, in brain hemispheres, L-DOPA produced a decrease in GAD and GABA-T activity. No changes, however, observed xobserved in GAD activity at the retinal level, whereas GABA-T activity was significantly decreased and GABA content increased. In conclusion, the present experiments show that in some areas of the brain the administration of L-DOPA is able to affect GABA turnover.
Effects of L-DOPA on GABA metabolism in chick brain and retina.
LANOTTE, Michele Maria Rosario;
1979-01-01
Abstract
The effects of an oral subacute treatment with L-DOPA on L glutamate decarboxylase (GAD), GABA and GABA transaminase (GABA-T) in chick n. basalis (homologous to the mammalian striatum), brain hemispheres, brain stem and retina were studied. A significant increase in n. basalis GAD activity associated with an increase in GABA content and decrease of GABA-T activity was shown to occur. Similar effects were observed in the brain stem except for GABA-T which was stimulated. In contrast, in brain hemispheres, L-DOPA produced a decrease in GAD and GABA-T activity. No changes, however, observed xobserved in GAD activity at the retinal level, whereas GABA-T activity was significantly decreased and GABA content increased. In conclusion, the present experiments show that in some areas of the brain the administration of L-DOPA is able to affect GABA turnover.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
