Gauze-based negative pressure wound therapy: a valid method to manage pyoderma gangrenosum?

Pyoderma gangrenosum (PG) is an uncommon ulcerative, non infective chronic inflammatory skin disorder of unknown etiology. Systemic therapies are necessary to control the associated medical diseases and, due to the inflammatory nature of PG, topical or systemic immunosuppressant agents are effective, but wound healing is usually slow. Negative wound pressure therapy (NPWT) has become an important tool for the management of complex skin ulcers and usage in PG has been recently described in literature: we present four cases of classic PG in which NPWT in association with systemic therapy achieved wound healing and a drastic pain reduction.