Endothelin-1 (ET-1) is an endothelium-derived vasoconstrictive peptide. In this study the Authors measured in 25 subjects (15 with essential hypertension and 10 normal) plasma levels of endothelin-l. Patients with hypertension had significantly higher plasma ET-l concentration than normal subjects (2.18 ± 1.07 vs. 1.36 ± 0.40 pg/ml, p < 0.02). Plasma arginine vasopressine, renin activity and aldosterone concentration did not show significant differences between hypertensive and normotensive subjects. These data suggest that ET-1 may be involved in the development or maintenance of hypertension.
Increase in plasma levels of endothelin in patients with essential hypertension [INCREMENTO DEI LIVELLI PLASMATICI DI ENDOTELINA IN PAZIENTI CON IPERTENSIONE ARTERIOSA ESSENZIALE]
DE ROSA, Francesco Giuseppe;
1996-01-01
Abstract
Endothelin-1 (ET-1) is an endothelium-derived vasoconstrictive peptide. In this study the Authors measured in 25 subjects (15 with essential hypertension and 10 normal) plasma levels of endothelin-l. Patients with hypertension had significantly higher plasma ET-l concentration than normal subjects (2.18 ± 1.07 vs. 1.36 ± 0.40 pg/ml, p < 0.02). Plasma arginine vasopressine, renin activity and aldosterone concentration did not show significant differences between hypertensive and normotensive subjects. These data suggest that ET-1 may be involved in the development or maintenance of hypertension.
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