Our findings indicate that ACEI may worsen OSA in subjects who develop upper airway irritation during treatment. In OSA, soft palate inflammation has been described as a consequence of snoring and of repeated closure/opening of the airway passages. The parallel decrease of eNO and AHI after ACEI withdrawal, suggests that cough and obstructive apnoeas were, at least in part, sustained by ACEI-induced upper airway inflammation. Our findings indicate that ACEI may increase the degree of OSA-induced inflammation and thus contribute to upper airway collapsibility during sleep

ACE-inhibitors and obstructive sleep apnoea

BUCCA, Caterina;BRUSSINO, Luisa;CICOLIN, Alessandro
2005

Abstract

Our findings indicate that ACEI may worsen OSA in subjects who develop upper airway irritation during treatment. In OSA, soft palate inflammation has been described as a consequence of snoring and of repeated closure/opening of the airway passages. The parallel decrease of eNO and AHI after ACEI withdrawal, suggests that cough and obstructive apnoeas were, at least in part, sustained by ACEI-induced upper airway inflammation. Our findings indicate that ACEI may increase the degree of OSA-induced inflammation and thus contribute to upper airway collapsibility during sleep
EUROPEAN RESPIRATORY SOCIETY ANNUAL CONGRESS
COPENHAGEN, DANIMARCA
17-21/09/2005
26
49
358
358
ACE inhibitors; OSA
C. Bucca; L. Brussino; E. Panaro; P. Bigo; L. Mangiardi; A. Cicolin
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/122243
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