VitaminB12 deficiency may favour cough by promoting neurogenic inflammation. We examined 30 nonasthmatic patients with chronic cough due to upper airway disease resistant to conventionaltreatmentandnormallungfunctiontests,15with vit. B12deficiency(serumvaluebelow250pg/ml),group1,and15withnormal vit. B12,group2. Methods: Histamine responsivenessoftheextrathoracic(PC25MIF50) andin- trathoracic airway(PC20FEV1), histaminecoughthreshold(PC5coughs) andexhaled nitric oxide(FeNO)wereassessedbeforeandaftertreatmentwithvitaminB12 (1000 mcgi.m.onceaweek)for2months. Results: In baseline,thetwogroupshadsimilarbronchialresponsiveness,cough threshold andFeNO.Group1patientshadsignificantlylowerextrathoracicairway threshold (p=0.043).TreatmentwithvitaminB12producedsignificantincreasein cough andairwaythresholdsandinFeNOonlyinvitaminB12deficiencygroup, see Table. Conclusions: VitaminB12deficiencymaycontributetothepathogenesisofcough and airwayhyperresponsivenessandmayaccountfortheresistancetoetiologic treatment. TheincreaseinFeNOaftertreatmentwithvitaminB12isconsistent with theabilityofcobalamintoactasadonorofNOandsuggeststhatFeNOis not agoodmarkerofairwayinflammationinsubjectswithvitaminB12deficiency.
Chronic cough, exhaled nitric oxide and vitamin B12 deficiency .
GUIDA, Giuseppe;BRUSSINO, Luisa;CULLA, Beatrice;ROLLA, Giovanni;BUCCA, Caterina
2007-01-01
Abstract
VitaminB12 deficiency may favour cough by promoting neurogenic inflammation. We examined 30 nonasthmatic patients with chronic cough due to upper airway disease resistant to conventionaltreatmentandnormallungfunctiontests,15with vit. B12deficiency(serumvaluebelow250pg/ml),group1,and15withnormal vit. B12,group2. Methods: Histamine responsivenessoftheextrathoracic(PC25MIF50) andin- trathoracic airway(PC20FEV1), histaminecoughthreshold(PC5coughs) andexhaled nitric oxide(FeNO)wereassessedbeforeandaftertreatmentwithvitaminB12 (1000 mcgi.m.onceaweek)for2months. Results: In baseline,thetwogroupshadsimilarbronchialresponsiveness,cough threshold andFeNO.Group1patientshadsignificantlylowerextrathoracicairway threshold (p=0.043).TreatmentwithvitaminB12producedsignificantincreasein cough andairwaythresholdsandinFeNOonlyinvitaminB12deficiencygroup, see Table. Conclusions: VitaminB12deficiencymaycontributetothepathogenesisofcough and airwayhyperresponsivenessandmayaccountfortheresistancetoetiologic treatment. TheincreaseinFeNOaftertreatmentwithvitaminB12isconsistent with theabilityofcobalamintoactasadonorofNOandsuggeststhatFeNOis not agoodmarkerofairwayinflammationinsubjectswithvitaminB12deficiency.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
