Objective:The adhesion molecules (CAM) play a critical role in the migration of leucocytes and adhesion of platelets to activated endothelium.Evidences support a correlation between CAM and serum lipid levels but few studies have been performed in paediatrics.Aim of this study was to analyze these molecules in a paediatric dyslipemic cohort lacking additional risk factors.Methods:74 children (9.6yrs±4.1) affected by primary dyslipidemia and a matched control group (C) of 20 children underwent plasma sP-Selectin and sICAM-1 detection, measured by Parameter Immunoassay (RD System,MN,USA).Aorta and carotid intima-media thickness were measured by an ultrasonographic B-mode high resolution system (ALT Apogee 800plus,USA).Multiple logistic regression models analysis was performed by SPSS software and a p value<0.01 was considered statistically significant.Results:Mean TC levels (mg%±sd) resulted 238±55.4 in patients and 174±25.9 in C; LDL-C mean concentrations (mg%±sd) resulted 163.2±53.3 vs 98.8±12.0 in patients vs C.Increased mean levels of sP-Selectin (ng/ml) were observed in patients compared to C (127.7±56.5 vs 16.5±3.8) (p<0.0001); also mean sICAM-1 value resulted higher in patients (ng/ml±sd 306.7±103.02) compared to normal (211 ng/ml).A significant positive correlation was found between sP-Selectin and carotid wall thickness (r = 2,59, p = 0,013).Conclusions:The present study shows that in dyslipidemic patients adhesion molecules can be markers of disease since childhood.Prospective studies are recommended to further evaluate their role in the diagnosis, treatment and follow up.
The inflammation biomarkers correlate with intima-media thickness in dyslipemic children.
MARTINO, Silvana;GUARDAMAGNA, Ornella
2006-01-01
Abstract
Objective:The adhesion molecules (CAM) play a critical role in the migration of leucocytes and adhesion of platelets to activated endothelium.Evidences support a correlation between CAM and serum lipid levels but few studies have been performed in paediatrics.Aim of this study was to analyze these molecules in a paediatric dyslipemic cohort lacking additional risk factors.Methods:74 children (9.6yrs±4.1) affected by primary dyslipidemia and a matched control group (C) of 20 children underwent plasma sP-Selectin and sICAM-1 detection, measured by Parameter Immunoassay (RD System,MN,USA).Aorta and carotid intima-media thickness were measured by an ultrasonographic B-mode high resolution system (ALT Apogee 800plus,USA).Multiple logistic regression models analysis was performed by SPSS software and a p value<0.01 was considered statistically significant.Results:Mean TC levels (mg%±sd) resulted 238±55.4 in patients and 174±25.9 in C; LDL-C mean concentrations (mg%±sd) resulted 163.2±53.3 vs 98.8±12.0 in patients vs C.Increased mean levels of sP-Selectin (ng/ml) were observed in patients compared to C (127.7±56.5 vs 16.5±3.8) (p<0.0001); also mean sICAM-1 value resulted higher in patients (ng/ml±sd 306.7±103.02) compared to normal (211 ng/ml).A significant positive correlation was found between sP-Selectin and carotid wall thickness (r = 2,59, p = 0,013).Conclusions:The present study shows that in dyslipidemic patients adhesion molecules can be markers of disease since childhood.Prospective studies are recommended to further evaluate their role in the diagnosis, treatment and follow up.
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