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EnglishBackground: Familial combined hyperlipemia (FCHL) is a common, atherogenic lipid disorder characterized by a variable phenotypic expression of hyperlipidemia. Diet is the first therapeutic approach to hyperlipoproteinaemias, particulary in children. Aim of the study: We determined the effect of 4 diet regimens on lipoprotein profile in FCHL affected children. Design: 20 FCHL patients (74 years) sequentially adhered to the following diets:1)habitual diet (HD): lipid 35%, satured fat 12%, PUFA 3%, carbohydrate 50%, protein 15%; 2)controlled diet (CD): lipid 27%, saturated fat 7%, PUFA 3%, carbohydrate 56%,protein 17%; 3)controlled diet plus rice bran oil (CD+I): lipid 26%, saturated fat 6%, PUFA 6%, carbohydrate 59%, protein 15%; 4)habitual diet plus rice bran oil (HD+I): lipid 33%, saturated fat 10%, PUFA 5%, carbohydrate 51%, protein 16%. Each patient was submitted to biochemical evaluation in the course of each trial. Total cholesterol (TC), triglycerides (Tg), LDL-cholesterol (LDL-C) with immunoenzymatic method and apoB, apoA with immunoturbidimetric method. Results: A decrease in TC, LDL-C, apoB and Tg were observed in course of all diet regimens. During CD, CD+I, HD+I trials, the observed TC and LDL-C reduction were respectively 12%, 13%, 14% for the former and 12%, 18%, 16% for the latter. All this values were statistically significant. Furthermore an ameliorating profile concerned Tg; this improvement was less evident during CD (6%) and CD+I (10%), while in course of HD+I the decrease observed was 20%. Conclusions: Diet has a key role and represents the basic therapeutic approach in FCHL children. Furthermore the P:M:S=1:2,6:2 ratio resulted in lower TC, Tg, apo B levels.
| Titolo: | Diet in the treatment of familial combined hyperlipidemia in children |
| Autori Riconosciuti: | |
| Autori: | Giachino P; Occhiuto L; Rutto E; Guardamagna O. |
| Data di pubblicazione: | 2003 |
| Abstract: | Background: Familial combined hyperlipemia (FCHL) is a common, atherogenic lipid disorder characterized by a variable phenotypic expression of hyperlipidemia. Diet is the first therapeutic approach to hyperlipoproteinaemias, particulary in children. Aim of the study: We determined the effect of 4 diet regimens on lipoprotein profile in FCHL affected children. Design: 20 FCHL patients (74 years) sequentially adhered to the following diets:1)habitual diet (HD): lipid 35%, satured fat 12%, PUFA 3%, carbohydrate 50%, protein 15%; 2)controlled diet (CD): lipid 27%, saturated fat 7%, PUFA 3%, carbohydrate 56%,protein 17%; 3)controlled diet plus rice bran oil (CD+I): lipid 26%, saturated fat 6%, PUFA 6%, carbohydrate 59%, protein 15%; 4)habitual diet plus rice bran oil (HD+I): lipid 33%, saturated fat 10%, PUFA 5%, carbohydrate 51%, protein 16%. Each patient was submitted to biochemical evaluation in the course of each trial. Total cholesterol (TC), triglycerides (Tg), LDL-cholesterol (LDL-C) with immunoenzymatic method and apoB, apoA with immunoturbidimetric method. Results: A decrease in TC, LDL-C, apoB and Tg were observed in course of all diet regimens. During CD, CD+I, HD+I trials, the observed TC and LDL-C reduction were respectively 12%, 13%, 14% for the former and 12%, 18%, 16% for the latter. All this values were statistically significant. Furthermore an ameliorating profile concerned Tg; this improvement was less evident during CD (6%) and CD+I (10%), while in course of HD+I the decrease observed was 20%. Conclusions: Diet has a key role and represents the basic therapeutic approach in FCHL children. Furthermore the P:M:S=1:2,6:2 ratio resulted in lower TC, Tg, apo B levels. |
| Volume: | 13 (5) |
| Pagina iniziale: | 305 |
| Pagina finale: | 305 |
| Nome del convegno: | XVII Convegno Nazionale SISA |
| Luogo del convegno: | Napoli |
| Anno del convegno: | 26-29 nov |
| Parole Chiave: | macronutrients; dietaty fat; acid fat ratio; dietary treatment; familial hyperlipidemia; children |
| Rivista: | NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES |
| Appare nelle tipologie: | 04B-Conference paper in rivista |
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