Background: The onset of atherosclerosis anticipates any clinical presentation and is demonstrated to occur in paediatrics. Aim of this study is to detect minimal changes of carotid and aorta intimal-media thickness (cIMT, aIMT) in dislipemic children, and to check any correlations with biochemical parameters. Methods: 100 subjects, 35 healthy controls (9,3± 5.0 years) and 65 patients (9,5±4,2 years) were submitted to biochemical analysis of lipoprotein profile tested with standard methods and to B-mode high-resolution ultrasonography, employing 7,5-10 MHz probes. Results: The total cholesterol (TC), LDL-C, apo B and triglycerides (Tg) (mg% , M±SD) resulted 259±62, 179±58, 121±29, 102±51 and 165±18, 92±17, 74±14, 69±25, in patients and control subjects respectively. This values are statistically significant (t- test). Echographic results of cIMT show a difference between patient and controls (0,49±0,9 and 0,43±0,1 mm), as well as aIMT (0,55±0,1 and 0,49±0,1 mm). When correlations between IMT were compared with any variables, a positive correlation appears and shows a predictive value of cIMT, which concerns TC and LDL-C (p=0,04) as well as apo B (p=0,009) in FH patients. Furthermore the aIMT shows a positive correlation with TC (p=0,07) in controls and BMI (p=0,08) in patients. Conclusions: In the present hyperlipemic paediatrics cohoort both biochemical and ultrasonographic pattern shows a great difference with healthy controls. Thus a selective screening of siblings of hyperlipidemic family is mandatory to early detect and treat any patients resulted affected.
The diagnosis of preclinical atherosclerosis in paediatrics.
GUARDAMAGNA, Ornella;
2003-01-01
Abstract
Background: The onset of atherosclerosis anticipates any clinical presentation and is demonstrated to occur in paediatrics. Aim of this study is to detect minimal changes of carotid and aorta intimal-media thickness (cIMT, aIMT) in dislipemic children, and to check any correlations with biochemical parameters. Methods: 100 subjects, 35 healthy controls (9,3± 5.0 years) and 65 patients (9,5±4,2 years) were submitted to biochemical analysis of lipoprotein profile tested with standard methods and to B-mode high-resolution ultrasonography, employing 7,5-10 MHz probes. Results: The total cholesterol (TC), LDL-C, apo B and triglycerides (Tg) (mg% , M±SD) resulted 259±62, 179±58, 121±29, 102±51 and 165±18, 92±17, 74±14, 69±25, in patients and control subjects respectively. This values are statistically significant (t- test). Echographic results of cIMT show a difference between patient and controls (0,49±0,9 and 0,43±0,1 mm), as well as aIMT (0,55±0,1 and 0,49±0,1 mm). When correlations between IMT were compared with any variables, a positive correlation appears and shows a predictive value of cIMT, which concerns TC and LDL-C (p=0,04) as well as apo B (p=0,009) in FH patients. Furthermore the aIMT shows a positive correlation with TC (p=0,07) in controls and BMI (p=0,08) in patients. Conclusions: In the present hyperlipemic paediatrics cohoort both biochemical and ultrasonographic pattern shows a great difference with healthy controls. Thus a selective screening of siblings of hyperlipidemic family is mandatory to early detect and treat any patients resulted affected.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
