BACKGROUND At present is generally accepted that atherosclerosis lesions begin in childhood, as demonstrated by autoptic pictures. Recent studies successfully demonstrate this degenerative change by ultrasound techniques. AIM of this study is to evaluate the predictive value of this ultrasonographic method in a familial combined hyperperlipidemia (FCHL) children and adults cohort. METHODS: 22 FCHL children aged 9±5 yrs , and their affected parents (41,5±6,2 yrs), as well as a matched control group, were recruited from patients affering to our lipid clinic. All patients were submitted to lipid profile evaluation. The aorta and carotid intima-media thickness (IMT) were evaluated with an high resolution B-mode ultrasonography using echotomographic system (ATL Apogee 800 plus, USA) with a 7,5 to 10 MHz linear transducer. RESULTS: Total cholesterol, LDL- cholesterol and apo B in children and adults were respectively 223±62, 153±60, and 114±35 mg% versus 285±44, 174±37, and 122±19 mg%. Preliminary results indicate that carotid and aortic IMT were abnormal in 50% of the children and 63% of the adults and resulted >0,47 mm.for the carotid thickness and 0,49 mm. for the aorta thickness in children. CONCLUSIONS: Our results demonstrate that ultrasonographic technique is reliable to identify arterial wall minimal changes. This was firstly performed in pediatric FCHL patients., as well as in their parents. Finally, this method results useful to detect in vivo, with an uninvasive technique subclinical atherosclerosis. Moreover it provide us a tool to screen high risk patients.
Evaluation of the intima-media thickness in familial combined hyperlipemia.
BONDONE, claudia;BO, Mario;GUARDAMAGNA, Ornella
2002-01-01
Abstract
BACKGROUND At present is generally accepted that atherosclerosis lesions begin in childhood, as demonstrated by autoptic pictures. Recent studies successfully demonstrate this degenerative change by ultrasound techniques. AIM of this study is to evaluate the predictive value of this ultrasonographic method in a familial combined hyperperlipidemia (FCHL) children and adults cohort. METHODS: 22 FCHL children aged 9±5 yrs , and their affected parents (41,5±6,2 yrs), as well as a matched control group, were recruited from patients affering to our lipid clinic. All patients were submitted to lipid profile evaluation. The aorta and carotid intima-media thickness (IMT) were evaluated with an high resolution B-mode ultrasonography using echotomographic system (ATL Apogee 800 plus, USA) with a 7,5 to 10 MHz linear transducer. RESULTS: Total cholesterol, LDL- cholesterol and apo B in children and adults were respectively 223±62, 153±60, and 114±35 mg% versus 285±44, 174±37, and 122±19 mg%. Preliminary results indicate that carotid and aortic IMT were abnormal in 50% of the children and 63% of the adults and resulted >0,47 mm.for the carotid thickness and 0,49 mm. for the aorta thickness in children. CONCLUSIONS: Our results demonstrate that ultrasonographic technique is reliable to identify arterial wall minimal changes. This was firstly performed in pediatric FCHL patients., as well as in their parents. Finally, this method results useful to detect in vivo, with an uninvasive technique subclinical atherosclerosis. Moreover it provide us a tool to screen high risk patients.
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