In this complex work, the investigators unveil new mechanisms by which ATRA (an active metabolite of Vitamin A) affects the regulation of CD38. ATRA is known to bind a family of receptors (RAR), which in turn interact with RARE, localized in intron 1 of the CD38 gene (phase 1) [2]. The key new insight is that ATRA/RAR/RARE binding is the early phase of a multistep process, which includes a delayed phase mediated through response elements in the 5′-upstream region of CD38. This second step requires de novo synthesis of PKC-δ, which likely acts on a sequence element for C/EBPβ, a noncanonical ATRA-responsive element [3]. Another important finding is that Am80 also contributes to the regulation of CD38 expression but that its effects only involve the early-phase response
Editorial: Cd38 and retinoids: a step toward a cure
MALAVASI, Fabio
2011-01-01
Abstract
In this complex work, the investigators unveil new mechanisms by which ATRA (an active metabolite of Vitamin A) affects the regulation of CD38. ATRA is known to bind a family of receptors (RAR), which in turn interact with RARE, localized in intron 1 of the CD38 gene (phase 1) [2]. The key new insight is that ATRA/RAR/RARE binding is the early phase of a multistep process, which includes a delayed phase mediated through response elements in the 5′-upstream region of CD38. This second step requires de novo synthesis of PKC-δ, which likely acts on a sequence element for C/EBPβ, a noncanonical ATRA-responsive element [3]. Another important finding is that Am80 also contributes to the regulation of CD38 expression but that its effects only involve the early-phase response
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