CINECA IRIS Institutional Research Information System

Transcriptome-wide gene expression outlier analysis pinpoints therapeutic vulnerabilities in colorectal cancer

Multiple strategies are continuously being explored to expand the drug target repertoire in solid tumours. We devised a novel computational workflow for transcriptome-wide gene expression outlier analysis that allows the systematic identification of both overexpression and underexpression events in cancer cells. Here it was applied to expression values obtained through RNA sequencing in 226 colorectal cancer (CRC) cell lines that were also characterized by whole exome sequencing and microarra...

ADENOVIRAL-BASED VACCINE PROMOTES NEOANTIGEN-SPECIFIC CD8+ T CELL STEMNESS AND TUMOR REJECTION

Upon chronic antigen exposure, CD8+ T cells become exhausted, acquiring a dysfunctional state correlated with the inability to control infection or tumor progression. In contrast, stem- like CD8+ T progenitors maintain the ability to promote and sustain effective immunity. Adenovirus (Ad)–vectored vaccines encoding tumor neoantigens have been shown to eradicate large tumors when combined with anti–programmed cell death protein 1 (PD-1) in murine models; however, the mechanisms and translatio...

Defects in Conformal Field Theory with O(N) Symmetry

Conformal field theories (CFTs) are essential tools in quantum field theory and statistical physics, providing a framework for understanding critical phenomena and renormalisation group flows, with further applications to other formal areas of theoretical physics. In recent years, extended excitations within these theories–such as conformal defects–have gained prominence as powerful probes of quantum field theories, offering insights into dualities and symmetries. Moreover, conformal defects ...

Mutational signatures of colorectal cancers according to distinct computational workflows