The complex system of molecular communications underlying cell biochemistry and function involves numerous components including kinases, phosphatases and transcription factors, which are known to be sensitive to cellular and tissue redox changes. Reactive oxygen species (ROS), whose constitutive generation in cells and tissues is amplified under pro-oxidant conditions, are now unanimously recognized to be important triggers and modulators of cell signaling, and consequently of cell behavior. This review considers the major signaling pathways that mediate gene regulation in response to ROS.

New insights into redox-modulated cell signaling

LEONARDUZZI, Gabriella Marisa;SOTTERO, Barbara;TESTA, GABRIELLA;BIASI, Fiorella;POLI, Giuseppe
2011-01-01

Abstract

The complex system of molecular communications underlying cell biochemistry and function involves numerous components including kinases, phosphatases and transcription factors, which are known to be sensitive to cellular and tissue redox changes. Reactive oxygen species (ROS), whose constitutive generation in cells and tissues is amplified under pro-oxidant conditions, are now unanimously recognized to be important triggers and modulators of cell signaling, and consequently of cell behavior. This review considers the major signaling pathways that mediate gene regulation in response to ROS.
2011
17
3994
4006
reactive oxygen species; oxidative stress; cell signaling
Leonarduzzi G; Sottero B; Testa G; Biasi F; Poli G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/131111
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