An MeV ion-microbeam lithographic technique can be successfully employed for the fabrication of an all-carbon miniaturized cellular biosensor based on graphitic microchannels embedded in a single-crystal diamond matrix. The device is functionally characterized for the in vitro recording of quantal exocytic events from single chromaffin cells, with high sensitivity and signal-to-noise ratio, opening promising perspectives for the realization of monolithic all-carbon cellular biosensors.

A new diamond biosensor with integrated graphitic microchannels for detecting quantal exocytic events from chromaffin cells

PICOLLO, FEDERICO;GOSSO, SARA;VITTONE, Ettore;CARBONE, Emilio;OLIVERO, Paolo;CARABELLI, Valentina
2013-01-01

Abstract

An MeV ion-microbeam lithographic technique can be successfully employed for the fabrication of an all-carbon miniaturized cellular biosensor based on graphitic microchannels embedded in a single-crystal diamond matrix. The device is functionally characterized for the in vitro recording of quantal exocytic events from single chromaffin cells, with high sensitivity and signal-to-noise ratio, opening promising perspectives for the realization of monolithic all-carbon cellular biosensors.
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http://onlinelibrary.wiley.com/doi/10.1002/adma.201300710/abstract?systemMessage=Wiley+Online+Library+will+be+unavailable+for+approximately+4+hours+between+09%3A00+EDT+and+14%3A00+EDT+on+Saturday%2C+28+September+2013+as+we+make+upgrades+to+improve+our+services+to+you.+There+will+also+be+some+delays+to+online+publishing+between+25+to+28+September+2013.+We+apologize+for+the+inconvenience+and+appreciate+your+patience.+Thank+you+for+using+Wiley+Online+Library%21
cellular biosensors; exocytosis; ion beam lithography; single-crystal diamond
F. Picollo;S. Gosso;E. Vittone;A. Pasquarelli;E. Carbone;P. Olivero;V. Carabelli
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/138312
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