Purpose: Wraige et al. (2005) proposed a classification for subtypes of pediatric AIS identifying aetiologies relevant for this age group, and susceptible of specific treatment. Aim of the study was to evaluate applicability of Wraige classification in children with AIS diagnosed at our tertiary care hospital between 2000–2008 (retrospectively before 2006 and prospectively thereafter). Methdos: Cases were identified by a computer-assisted search using International Classification of Disease IX, codes 430–438 for cerebrovascular diseases. Clinical records were reviewed identifying eligible patients. Inclusion criteria were: age 1 month–18 years, diagnosis of AIS defined as an acute focal neurological deficit lasting more than 24 h with evidence of cerebral infarction in an arterial distribution on brain imaging. A presumed stroke subtype was assigned according to Wraige classification on the basis of clinical, radiological and laboratory data (independently by three of the authors with neurological competence). Results: Thirty-five identified patients were considered eligible for the study. Mean age at onset was 5.7 years (range 5 months–17 years). The following ‘‘Wraige’’ subtypes categorization was assigned: 3/35 (8.6%) sickle cell disease, 2/35 (5.8%) cardioembolic, 1/35 (2.8%) Moya-Moya, 2/35 (5.8%) cervical arterial dissection, 6/35 (17%) steno-occlusive cerebral arteriopathy, 9/35 (26%) other determined aetiology (including four acute lymphoblastic leukaemia), 11/35 (31.4%) multiple probable/possible aetiologies and 1/35 (2.8%) undetermined aetiology. Conclusions: We found high incidence of ‘‘multiple’’ and ‘‘determined ‘‘aetiologies for AIS categorization in our series confirming that AIS in children is often heterogeneous and multifactorial. Wraige classification resulted in a useful methodological tool for clinical practice. Disclosure of interest: none declared.
A retrospective and prospective single centre study onapplicability of the proposed Wraige classification forsubtypes of arterial ischemic stroke (AIS) in children
LICARI, VITALBA;MARINACCIO, CRISTINA;PAGANA, LUCIA;BASSI, Bianca
2009-01-01
Abstract
Purpose: Wraige et al. (2005) proposed a classification for subtypes of pediatric AIS identifying aetiologies relevant for this age group, and susceptible of specific treatment. Aim of the study was to evaluate applicability of Wraige classification in children with AIS diagnosed at our tertiary care hospital between 2000–2008 (retrospectively before 2006 and prospectively thereafter). Methdos: Cases were identified by a computer-assisted search using International Classification of Disease IX, codes 430–438 for cerebrovascular diseases. Clinical records were reviewed identifying eligible patients. Inclusion criteria were: age 1 month–18 years, diagnosis of AIS defined as an acute focal neurological deficit lasting more than 24 h with evidence of cerebral infarction in an arterial distribution on brain imaging. A presumed stroke subtype was assigned according to Wraige classification on the basis of clinical, radiological and laboratory data (independently by three of the authors with neurological competence). Results: Thirty-five identified patients were considered eligible for the study. Mean age at onset was 5.7 years (range 5 months–17 years). The following ‘‘Wraige’’ subtypes categorization was assigned: 3/35 (8.6%) sickle cell disease, 2/35 (5.8%) cardioembolic, 1/35 (2.8%) Moya-Moya, 2/35 (5.8%) cervical arterial dissection, 6/35 (17%) steno-occlusive cerebral arteriopathy, 9/35 (26%) other determined aetiology (including four acute lymphoblastic leukaemia), 11/35 (31.4%) multiple probable/possible aetiologies and 1/35 (2.8%) undetermined aetiology. Conclusions: We found high incidence of ‘‘multiple’’ and ‘‘determined ‘‘aetiologies for AIS categorization in our series confirming that AIS in children is often heterogeneous and multifactorial. Wraige classification resulted in a useful methodological tool for clinical practice. Disclosure of interest: none declared.
| File | Dimensione | Formato | |
|---|---|---|---|
|
ID_431627.pdf
Accesso riservato
Tipo di file:
POSTPRINT (VERSIONE FINALE DELL’AUTORE)
Dimensione
74.21 kB
Formato
Adobe PDF
|
74.21 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
