By design: The novel MRI reporter GdIII-dota-en-pba (see picture) selectively binds to sialic acid residues, which are overexpressed on tumors. This imaging reporter accumulates in a murine melanoma B16-F10 mice xenograft and from the MRI signal intensity it is possible to quantify the sialic acid concentration that is directly associated with tumor malignancy.
MRI Visualization of Melanoma Cells by Targeting Overexpressed Sialic Acid with a GdIII-dota-en-pba Imaging Reporter
GENINATTI CRICH, Simonetta;ALBERTI, DIEGO;AIME, Silvio;
2013-01-01
Abstract
By design: The novel MRI reporter GdIII-dota-en-pba (see picture) selectively binds to sialic acid residues, which are overexpressed on tumors. This imaging reporter accumulates in a murine melanoma B16-F10 mice xenograft and from the MRI signal intensity it is possible to quantify the sialic acid concentration that is directly associated with tumor malignancy.
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