Background: Short-term exposure to air pollution has adverse effects among patients with asthma, whether long-term exposure to air pollution is a cause of adult-onset asthma is unclear. Objective: To investigate the association between air pollution and adult onset asthma. Methods: Asthma incidence was prospectively assessed in six European cohorts. Exposures studied were annual average concentrations at home addresses for nitrogen oxides assessed for 23,704 participants (including 1,257 incident cases) and particulate matter assessed for 17,909 participants through ESCAPE land-use regression models, and traffic exposure indicators. Metaanalyses of cohort-specific logistic regression on asthma incidence were performed. Models were adjusted on age, sex, overweight, education and smoking and included city/area within each cohort as a random effect. Results: In this longitudinal analysis, asthma incidence was positively, but not significantly, associated with all exposure metrics, except for PMcoarse. Positive associations of borderline significance were observed for NO2, (adjusted OR = 1.10; 95% CI: 0.99, 1.21 per 10 μg/m3; p=0.10) and NOx (1.04; 95% CI: 0.99, 1.08 per 20 μg/m3; p=0.08). Non-significant positive associations were estimated for PM10 (1.04; 95% CI: 0.88, 1.23 per 10 μg/m3), PM2.5 (1.04; 95% CI: 0.88, 1.23 per 5 μg/m3), PM2.5absorbance (1.06; 95% CI: 0.95, 1.19 per 10-5/m), traffic load (1.10; 95% CI: 0.93, 1.30 per four million vehicles x m/day on major roads in a 100m buffer) and traffic intensity (1.10; 95% CI: 0.93, 1.30 per 5,000 vehicles/day on the nearest road). A non-significant negative association was estimated for PM coarse (0.98; 95% CI: 0.87, 1.14 per 5 μg/m3). Conclusions: Results are suggestive of a deleterious effect of ambient air pollution on asthma incidence in adults. Further research with improved personal-level exposure assessment (versus residential exposure assessment only) and phenotypic characterization is needed.

Ambient Air Pollution and Adult Asthma Incidence in Six European Cohorts (ESCAPE)

BELLISARIO, VALERIA;BONO, Roberto;
2015

Abstract

Background: Short-term exposure to air pollution has adverse effects among patients with asthma, whether long-term exposure to air pollution is a cause of adult-onset asthma is unclear. Objective: To investigate the association between air pollution and adult onset asthma. Methods: Asthma incidence was prospectively assessed in six European cohorts. Exposures studied were annual average concentrations at home addresses for nitrogen oxides assessed for 23,704 participants (including 1,257 incident cases) and particulate matter assessed for 17,909 participants through ESCAPE land-use regression models, and traffic exposure indicators. Metaanalyses of cohort-specific logistic regression on asthma incidence were performed. Models were adjusted on age, sex, overweight, education and smoking and included city/area within each cohort as a random effect. Results: In this longitudinal analysis, asthma incidence was positively, but not significantly, associated with all exposure metrics, except for PMcoarse. Positive associations of borderline significance were observed for NO2, (adjusted OR = 1.10; 95% CI: 0.99, 1.21 per 10 μg/m3; p=0.10) and NOx (1.04; 95% CI: 0.99, 1.08 per 20 μg/m3; p=0.08). Non-significant positive associations were estimated for PM10 (1.04; 95% CI: 0.88, 1.23 per 10 μg/m3), PM2.5 (1.04; 95% CI: 0.88, 1.23 per 5 μg/m3), PM2.5absorbance (1.06; 95% CI: 0.95, 1.19 per 10-5/m), traffic load (1.10; 95% CI: 0.93, 1.30 per four million vehicles x m/day on major roads in a 100m buffer) and traffic intensity (1.10; 95% CI: 0.93, 1.30 per 5,000 vehicles/day on the nearest road). A non-significant negative association was estimated for PM coarse (0.98; 95% CI: 0.87, 1.14 per 5 μg/m3). Conclusions: Results are suggestive of a deleterious effect of ambient air pollution on asthma incidence in adults. Further research with improved personal-level exposure assessment (versus residential exposure assessment only) and phenotypic characterization is needed.
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http://ehp.niehs.nih.gov/1408206/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455584/
Bénédicte Jacquemin; Valérie Siroux; Margaux Sanchez; Anne-Elie Carsin; Tamara Schikowski; Martin Adam; Valeria Bellisario; Anna Buschka; Roberto Bono; Bert Brunekreef; Yutong Cai; Marta Cirach; Françoise Clavel-Chapelon; Christophe Declercq; Roberto de Marco; Audrey de Nazelle; Regina E. Ducret-Stich; Virginia Valeria Ferretti; Margaret W. Gerbase; Rebecca Hardy; Joachim Heinrich; Christer Janson; Deborah Jarvis; Zaina Al Kanaani; Dirk Keidel; Diana Kuh; Nicole Le Moual; Mark J. Nieuwenhuijsen; Alessandro Marcon; Lars Modig; Isabelle Pin; Thierry Rochat; Christian Schindler; Dorothea Sugiri; Morgane Stempfelet; Sofia Temam; Ming-Yi Tsai; Raphaëlle Varraso; Danielle Vienneau; Andrea Vierkötter; Anna L. Hansell; Ursula Krämer; Nicole M. Probst-Hensch; Jordi Sunyer; Nino Künzli; and Francine Kauffmann
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1508272
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