Introduction: The correlation between unfavorable lipid profile and the atherosclerosis is well recognized and the vascular damage begins in childhood. The prognostic value of apolipoprotein B (apoB) and non-HDL-cholesterol were demonstrated in adults as accurate index of cardiovascular disease (CVD) risk, greater than LDL-cholesterol. They should be evaluated also in selected children to predict accurately their CDV risk, but few studies about this aim have been reported in pediatrics. Objective: Estimate apoB and non-HDL-C levels and their possible relation to familial CVD in a cohort of children affected by primary dyslipidemias. Methods: A healthy and dyslipidemic cohort comprising 351 children and adolescents (2-18 years) was considered. According to international criterias for dyslipidemia’s diagnosis, a 2-generation genealogic tree to detect CVD and lipid profile was estimate by standard methods. Patients resulted: 159 FH, 76 FCHL, 79 Dominant Hypercholesterolemia (ADH), 37 controls. They were also subdivided into 4 age-groups: 0-4.9, 5-9.9, 10-14.9, 15-18.9 years. Statistical analysis were performed by SPSS18.0 software. Results: Independently of age, apoB and non-HDL-C levels were significantly higher in children affected by FH (133,5±29 and 219,9±53,5 mg/dl respectively) compared to other groups. Levels in FCHL and ADH patients were similar (apoB=92.6±17.6, non-HDL-C=151,1±29,5 mg/dl and apoB=90±30.6, non-HDL-C=142.7±21.3 mg/dl respectively) but they moved away in adolescence. Among patients, 68,6% had a family history of CVD events (CVD+), and 45,5% positive for precocious events (pCVD+). ApoB and non-HDL-C levels were higher in children CVD+ and pCVD+ but this difference was not statistically significant. Conclusion: The study showed how apoB and non-HDL-C are relevant biochemical markers to identify the diagnosis in a better way. Furthermore their levels represent an advantage over traditional lipid variables for the risk prediction also in childhood and should be routinely added to the standard lipid profile in children affected by primary dyslipidemia.

ApoB AND NON-HDL-CHOLESTEROL: CARDIOVASCULAR RISK FACTORS IN CHILDREN

ABELLO, Francesca;GUARDAMAGNA, Ornella
2011

Abstract

Introduction: The correlation between unfavorable lipid profile and the atherosclerosis is well recognized and the vascular damage begins in childhood. The prognostic value of apolipoprotein B (apoB) and non-HDL-cholesterol were demonstrated in adults as accurate index of cardiovascular disease (CVD) risk, greater than LDL-cholesterol. They should be evaluated also in selected children to predict accurately their CDV risk, but few studies about this aim have been reported in pediatrics. Objective: Estimate apoB and non-HDL-C levels and their possible relation to familial CVD in a cohort of children affected by primary dyslipidemias. Methods: A healthy and dyslipidemic cohort comprising 351 children and adolescents (2-18 years) was considered. According to international criterias for dyslipidemia’s diagnosis, a 2-generation genealogic tree to detect CVD and lipid profile was estimate by standard methods. Patients resulted: 159 FH, 76 FCHL, 79 Dominant Hypercholesterolemia (ADH), 37 controls. They were also subdivided into 4 age-groups: 0-4.9, 5-9.9, 10-14.9, 15-18.9 years. Statistical analysis were performed by SPSS18.0 software. Results: Independently of age, apoB and non-HDL-C levels were significantly higher in children affected by FH (133,5±29 and 219,9±53,5 mg/dl respectively) compared to other groups. Levels in FCHL and ADH patients were similar (apoB=92.6±17.6, non-HDL-C=151,1±29,5 mg/dl and apoB=90±30.6, non-HDL-C=142.7±21.3 mg/dl respectively) but they moved away in adolescence. Among patients, 68,6% had a family history of CVD events (CVD+), and 45,5% positive for precocious events (pCVD+). ApoB and non-HDL-C levels were higher in children CVD+ and pCVD+ but this difference was not statistically significant. Conclusion: The study showed how apoB and non-HDL-C are relevant biochemical markers to identify the diagnosis in a better way. Furthermore their levels represent an advantage over traditional lipid variables for the risk prediction also in childhood and should be routinely added to the standard lipid profile in children affected by primary dyslipidemia.
XXV Congresso Nazionale SISA
Roma
30 nov-3 dicembre 2011
3
48
48
biochemical marker; children; inherited dyslipidemia; prevention; cardiovascular risk
Assandro P.; Abello F.; Guardamagna O.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1519207
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