Objective. The relationship between lipoprotein profile and vascular damage is well recognized. Furthermore HDL-C represent an important biochemical marker related to overweight/obesity and to CVD risk in adults. Aim of this study was to evaluate the correlation between lipid biochemical markers (TC, LDL-C, HDL-C, apoB and apoA-I levels) and the staturo-ponderal growth in a cohort of dyslipidemic children. Study design. A cohort of 231 patients (aged 10.9±3.7 years) was enrolled. Seventy-six children resulted affected by FH, 68 by FCHL and 87 by dominant Hypercholesterolemia. Demographic data, medical history, physical examination and two generations family history of cardiovascular events were evaluated in the entire cohort. Children were submitted to biochemical analysis concerning TC, HDL-C, TG, apoB and apoA-I by standard methods, after an overnight fasting. Statistical analysis: Pearson correlation analysis was performed. Results. HDL-C resulted negatively correlated to BMI (r=-0.300, p<0.001), TG ApoB/ApoA1 (p<0.001) and positively correlated to TC and ApoA1 (p<0.001). Furthermore BMI resulted positively correlated to age and TG (p<0.001) and negatively to ApoA1. (p=0.048). Conclusion. The present findings indicate that HDL-C represent a significant parameter to check in children particularly when overweight occur.
HDL-C profile and BMI in dyslipidemic children.
ABELLO, Francesca;GUARDAMAGNA, Ornella
2010-01-01
Abstract
Objective. The relationship between lipoprotein profile and vascular damage is well recognized. Furthermore HDL-C represent an important biochemical marker related to overweight/obesity and to CVD risk in adults. Aim of this study was to evaluate the correlation between lipid biochemical markers (TC, LDL-C, HDL-C, apoB and apoA-I levels) and the staturo-ponderal growth in a cohort of dyslipidemic children. Study design. A cohort of 231 patients (aged 10.9±3.7 years) was enrolled. Seventy-six children resulted affected by FH, 68 by FCHL and 87 by dominant Hypercholesterolemia. Demographic data, medical history, physical examination and two generations family history of cardiovascular events were evaluated in the entire cohort. Children were submitted to biochemical analysis concerning TC, HDL-C, TG, apoB and apoA-I by standard methods, after an overnight fasting. Statistical analysis: Pearson correlation analysis was performed. Results. HDL-C resulted negatively correlated to BMI (r=-0.300, p<0.001), TG ApoB/ApoA1 (p<0.001) and positively correlated to TC and ApoA1 (p<0.001). Furthermore BMI resulted positively correlated to age and TG (p<0.001) and negatively to ApoA1. (p=0.048). Conclusion. The present findings indicate that HDL-C represent a significant parameter to check in children particularly when overweight occur.
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