Objective: The intima media thickness (IMT) is an excellent surrogate marker of subclinical atherosclerosis. ApoB and ApoA1 measured in children and adolescents reflect a lipoprotein profile predisposing to the development of atherosclerosis in adulthood. Aim of the study is to check the relationship between carotid IMT (cIMT) and aortic IMT (aIMT) and biochemical risk markers of atherosclerosis in childhood. Methods: a healthy and dyslipidemic cohort comprising 255 children and adolescents (age 1-18 ys) underwent B-mode ultrasound. In the group of dyslipidemic children 74 resulted affected by FH, 59 by FCHL, 32 by Hyperlipoprotein(a), 29 by dominant Hypercholesterolemia, 4 by FHTG and 1 by sitosterolemia. Finally 13 patients were obese or overweight. cIMT and aIMT were assessed by using B-mode ultrasound at 2 cm near the bulb and above the iliac bifurcation respectively and mean values were considered. Lipid profile was evaluated by standard methods. Statistical analysis were performed by SPSS15.0 software. Results: In all subjects IMT measurement increased with age independently from gender. In the whole cohort, cIMT positively correlated with LDL-C (rho=0.13, p=0.040) and non-HDL-C (rho=0.15, p=0.002), while a negative correlation was found with HDL-C (rho= -0.19, p=0.003) and ApoA1 (rho= -0.18, p=0.005). Furthermore both aIMT and cIMT resulted significantly related to Apo B levels (rho= 0.16, p=0.027; rho= 0.18, p=0.006). Conclusion: The present study detected, for the first time in children, a correlation between cIMT and non-HDL-C and ApoB as well as aIMT and ApoB. Recent guidelines have emphasized the importance of non-HDL-C as predictor of cardiovascular risk and ApoB as relevant proatherogenic marker, even stronger than LDL-C. Therefore these results support the usefulness of ApoB and non-HDL-C values, as well as cIMT and aIMT measurements, in pediatric lipid risk assessment.
Correlation between intima media thickness measurement and biochemical markers of atherosclerosis in childhood
ABELLO, Francesca;GUARDAMAGNA, Ornella
2009-01-01
Abstract
Objective: The intima media thickness (IMT) is an excellent surrogate marker of subclinical atherosclerosis. ApoB and ApoA1 measured in children and adolescents reflect a lipoprotein profile predisposing to the development of atherosclerosis in adulthood. Aim of the study is to check the relationship between carotid IMT (cIMT) and aortic IMT (aIMT) and biochemical risk markers of atherosclerosis in childhood. Methods: a healthy and dyslipidemic cohort comprising 255 children and adolescents (age 1-18 ys) underwent B-mode ultrasound. In the group of dyslipidemic children 74 resulted affected by FH, 59 by FCHL, 32 by Hyperlipoprotein(a), 29 by dominant Hypercholesterolemia, 4 by FHTG and 1 by sitosterolemia. Finally 13 patients were obese or overweight. cIMT and aIMT were assessed by using B-mode ultrasound at 2 cm near the bulb and above the iliac bifurcation respectively and mean values were considered. Lipid profile was evaluated by standard methods. Statistical analysis were performed by SPSS15.0 software. Results: In all subjects IMT measurement increased with age independently from gender. In the whole cohort, cIMT positively correlated with LDL-C (rho=0.13, p=0.040) and non-HDL-C (rho=0.15, p=0.002), while a negative correlation was found with HDL-C (rho= -0.19, p=0.003) and ApoA1 (rho= -0.18, p=0.005). Furthermore both aIMT and cIMT resulted significantly related to Apo B levels (rho= 0.16, p=0.027; rho= 0.18, p=0.006). Conclusion: The present study detected, for the first time in children, a correlation between cIMT and non-HDL-C and ApoB as well as aIMT and ApoB. Recent guidelines have emphasized the importance of non-HDL-C as predictor of cardiovascular risk and ApoB as relevant proatherogenic marker, even stronger than LDL-C. Therefore these results support the usefulness of ApoB and non-HDL-C values, as well as cIMT and aIMT measurements, in pediatric lipid risk assessment.
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