TB is currently the second cause of death among patients affected with infectious diseases. Quantification of drug levels in plasma and in cells where Mycobacterium tuberculosis persists and grows may be useful in understanding the appropriateness of dosage regimens. We report a new and fully validated chromatographic method to quantify first-line antituberculars in plasma and PBMCs. The method was used for plasma and cell quantification of antituberculars in patients undergoing treatment with standard oral therapy.

A UPLC-MS-MS method for the simultaneous quantification of first-line antituberculars in plasma and in PBMCs

BAIETTO, LORENA
Co-first
;
CALCAGNO, Andrea
Co-first
;
MOTTA, ILARIA;DI PERRI, Giovanni;BONORA, Stefano;D'AVOLIO, ANTONIO
Last
2015-01-01

Abstract

TB is currently the second cause of death among patients affected with infectious diseases. Quantification of drug levels in plasma and in cells where Mycobacterium tuberculosis persists and grows may be useful in understanding the appropriateness of dosage regimens. We report a new and fully validated chromatographic method to quantify first-line antituberculars in plasma and PBMCs. The method was used for plasma and cell quantification of antituberculars in patients undergoing treatment with standard oral therapy.
2015
70
9
2572
2575
HPLC; TDM; determination; ethambutol; isoniazid; peripheral blood mononuclear cells; pyrazinamide; rifampicin; therapeutic drug monitoring
Baietto, Lorena; Calcagno, Andrea; Motta, Ilaria; Baruffi, Katia; Poretti, Viviana; Di Perri, Giovanni; Bonora, Stefano; D'Avolio, Antonio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1528189
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