A series of, dehydroamino acids endowed with different protective groups at the amino and carboxylate moieties and with different substittents at the double bond have been reacted with parahydrogen. The observed Para Hydrogen Inchiced-Polarization (PHIP) effects in the H-1 NMRspectra are strongly dependent on the amino protecting group. DFT calculations allowed us to establish a relationship betWeen the structures of the reaction intermediates (whose energies depend on the amido substitution) and the observed PHIP patterns.

The Role of the Amino Protecting Group during Parahydrogenation of Protected Dehydroamino Acids

CERUTTI, ERIKA;VIALE, Alessandra;NERVI, Carlo;GOBETTO, Roberto;AIME, Silvio
2015-01-01

Abstract

A series of, dehydroamino acids endowed with different protective groups at the amino and carboxylate moieties and with different substittents at the double bond have been reacted with parahydrogen. The observed Para Hydrogen Inchiced-Polarization (PHIP) effects in the H-1 NMRspectra are strongly dependent on the amino protecting group. DFT calculations allowed us to establish a relationship betWeen the structures of the reaction intermediates (whose energies depend on the amido substitution) and the observed PHIP patterns.
2015
119
46
11271
11279
http://pubs.acs.org/jpca
Physical and Theoretical Chemistry
Cerutti, Erika; Viale, Alessandra; Nervi, Carlo; Gobetto, Roberto; Aime, Silvio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1545646
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